3 Nov 2016
Resistance to the key anti-malarial drug piperaquine has recently emerged in Cambodia, this research will help health officials to monitor its spread
Reporting in Lancet Infectious Diseases, scientists at the Wellcome Trust Sanger Institute and their collaborators have discovered genetic markers in malaria parasites linked with resistance to piperaquine.
27 Oct 2016
Genome study creates new conservation opportunities
Genome sequencing has revealed ancient gene mixing between chimpanzees and bonobos, mankind’s closest relatives, showing parallels with Neanderthal mixing in human ancestry. The study showed that 1% of chimpanzee genomes are derived from bonobos. It also found that genomics could aid chimpanzee conservation, by helping reveal the country of origin of individual chimpanzees.
20 Oct 2016
The revolutionary award will allow Dr Behjati to focus on finding treatments for childhood cancers without typical research restrictions
The Robert J. Arceci Innovation Award gives Dr Behjati the ability to pursue whatever leads he uncovers, and to focus on discovery and making a difference for patients. Dr Behjati plans to continue his work on understanding the cancer genome – the genetic changes that give rise to childhood cancer. He hopes to explore single cell sequencing technologies to understand where cancer cells come from and what the alternative fate of cancer cells might be. By understanding this path, Dr Behjati believes it might be possible to redirect a cancer cell to become something less harmful.
18 Oct 2016
Researchers have uncovered approximately 500 genes that are essential for cancer cell survival, including more than 200 for which drugs could be designed.
Researchers from the Wellcome Trust Sanger Institute and their collaborators have adapted a CRISPR gene editing technique and used it to find new therapeutic targets for acute myeloid leukaemia (AML).
14 Oct 2016
An ambitious global initiative to create a Human Cell Atlas - a description of every cell in the human body as a reference map to accelerate progress in biomedical science - was discussed at an International meeting in London on 13-14 October. Ultimately, the Human Cell Atlas would revolutionise how doctors and researchers understand, diagnose and treat disease.
The Human Cell Atlas initiative seeks to bring in a new era of cellular understanding, founded on the discovery of new cell types, and investigating how these cells change across time, during development and disease, to gain a better understanding of biology.
29 Sep 2016
PD-1 marker found in immune cells that can trigger asthma
A new therapeutic target for inflammatory diseases such as asthma and autoimmune disorders has been identified by scientists at the Wellcome Trust Sanger Institute. Published in Nature, the researchers found that the PD-1 protein is a marker for developing Innate Lymphoid Cells that can trigger asthma. PD-1 is a drug target for some cancers. These findings show that drugs that target PD-1 could also be developed for treating asthma and other inflammatory diseases.
26 Sep 2016
17 rare genetic variants found
Scientists from the Welcome Trust Sanger Institute and their collaborators have discovered 17 rare human genetic variations associated with risk factors for diseases such as heart disease and diabetes. Reported in Nature Genetics, the research shows how large-scale genomic datasets can be used to help identify potential novel biological targets for studying cardiovascular and other diseases.
23 Sep 2016
Sanger Institute Faculty member is recognised for his contribution to bioinformatics
Sanger Institute Faculty member Richard Durbin was honoured for a lifetime of pioneering research and innovation in the field of bioinformatics with the prestigious International Steven Hoogendijk Award at a ceremony on 23 September 2016.
21 Sep 2016
Evidence found for a single major 'Out of Africa' migration event
16 Sep 2016
Regular updates and exchanges of cancer data in childhood cancer will help both institutions and will be made freely available to researchers worldwide
The Wellcome Trust Sanger Institute is combining the power of COSMIC, its large-scale cancer genetics database, with ProteinPaint data mining and visualization system at St. Jude Children’s Research Hospital in Memphis TN, to support the discovery and understanding of genetic mutations in paediatric cancers.