23 Dec 2008

Genome study will drive forward targeted approach to cancer

The quest for personalized cancer treatments is given a boost today by the announcement of a $13M (£8.5M) UK-US alliance to find the best treatments for cancers. The scientists will use their skills in high-throughput research to test the sensitivity of 1,000 cancer cell samples to hundreds of known and novel molecular anti-cancer treatments and correlate these responses to the genes known to be driving the cancers.

17 Dec 2008

Novel approach to combine science publishing and wiki content for web 2.0

A novel experiment that combines web 2.0 and Wikipedia with traditional science publishing is announced today by RNA Biology. For the first time, researchers publishing research on families of RNA molecules in the journal will be required to write a Wikipedia page summarising their findings.

16 Dec 2008

Genome Boost for Genetics Researchers

The three-year project will use next-generation sequencing technologies to produce high-quality sequence for each of the strains. Mouse models are important for research into many human diseases. The DNA sequences of these 17 strains will help to identify and characterize many human disease-related genes.

14 Dec 2008

Brain genes associated with increased body mass

A genetic study of more than 90,000 people has identified six new genetic variants that are associated with increased Body Mass Index (BMI), the most commonly used measure of obesity. Five of the genes are known to be active in the brain, suggesting that many genetic variants implicated in obesity might affect behaviour, rather than the chemical processes of energy or fat metabolism.

7 Dec 2008

Population cohort study finds six genetic variants associated with 'bad' cholesterol

A new study presages a real aim of genetics: to look at whole populations to in order determine the significance of individual genetic variants for individual health. The research team, whose work is published in Nature Genetics, find six novel genetic variants that are associated with lipid levels, a common indicator of heart or artery disease.

7 Dec 2008

Population study finds genetics clues

A new genome-wide study examines genetic variants associated with nine metabolic traits and is the first to draw out novel variants from a population unselected for current disease. The traits are indicators for common disease such as cardiovascular disease, type 2 diabetes, blood pressure, inflammation and lipid levels.

7 Dec 2008

A connection between the body clock and abnormalities in metabolism and diabetes has been suggested in new research by an international team involving the University of Oxford, the Wellcome Trust Sanger Institute and the MRC Epidemiology Unit in Cambridge.

The researchers have identified a gene involved in the way the body responds to the 24-hour day-night cycle that is strongly linked to high blood sugar levels and an increased risk of type 2 diabetes. The results of the genome-wide association scan are published in Nature Genetics.

27 Nov 2008

New method to find important genome mutations in cancer

The new method, published in Proceedings of the National Academy of Sciences this week, allows researchers to screen thousands of genes in hundreds of tissue at one time. The technique should allow cancer researchers to establish rapidly which mutations are drivers and which are passengers, leading more swiftly to identification of important targets for development of diagnostics and therapies.

24 Nov 2008

First complete sequence of an individual African genome

Researchers at the Sanger Institute have announced that a study carried out in collaboration with Illumina scientists has yielded the first complete and publicly available sequence of an African individual human genome. The study, published in Nature, was executed using next-generation Illumina sequencing technologies to sequence the human genome with 99.9 per cent accuracy. The DNA sequenced was taken from the HapMap project and belongs to an individual from the Yoruba of Ibadan, Nigeria.

18 Nov 2008

The International Cancer Genome Consortium (ICGC) today announced the commitments of 11 funding organizations in eight countries to generate comprehensive, high-resolution analyses of genomic changes for eight forms of cancer found across the planet. Each organization will be coordinating studies of at least one specific type or subtype of cancer, with each project expected to involve specimens from approximately 500 patients and estimated to cost $20 million (USD). ICGC projects will use common standards of data collection and analysis that were proposed in the ICGC Goals, Structure, Policies and Guidelines released in April 2008.