News Archive - 2007

News Archive - 2007

Thirty years on: one human genome a day

Thirty years on: one human genome a day

Sanger Institute sequence production to increase 60-fold

The Wellcome Trust Sanger Institute has now made a major investment in new-technology sequencing platforms that will drive new exploration of the genetics of disease to a scale unattainable by current methods. The investment reinforces the role of the Institute as one of the largest sequencing centres on earth.

Mutant sperm guide clinicians to new diseases

Mutant sperm guide clinicians to new diseases

Disease, DNA, deletions and duplications in human sperm

Research published today in Nature Genetics shows that some rearrangements of the human genome occur more frequently than previously thought. The work is likely to lead to new identification of genes involved in disease and to improve diagnosis of genomic disease.

Inside DNA

Inside DNA

Unique travelling exhibition offers the public a chance to shape future science policy

Researchers and Public Engagement staff from the Wellcome Trust Sanger Institute made a major contribution to the £1.5 million five-year project Inside DNA: A Genomic Revolution, the first UK major touring exhibition on genomics

Largest-ever Alzheimer's gene study underway

Largest-ever Alzheimer's gene study underway

Wellcome Trust Sanger Institute to contribute genotyping

The genetics underlying late-onset Alzheimer's disease could soon be revealed thanks to a collaboration of leading UK experts. The team, led by scientists at Cardiff University, has received £1.3 million from the Wellcome Trust, the UK's largest medical research charity, to scan the entire human genome in search of the genes that predispose people to or protect them from developing the disease.

Major genetic breakthrough for ankylosing spondylitis brings treatment hope

Major genetic breakthrough for ankylosing spondylitis brings treatment hope

Research funded by the Wellcome Trust and the Arthritis Research Campaign has identified two genes implicated in the disease ankylosing spondylitis, a common disease primarily causing back pain and progressive stiffness.

The research, published online today in Nature Genetics, suggests that a treatment currently being trialled for Crohn's disease may also be applied to this disease.

Consortium Publishes Phase II Map of Human Genetic Variation

Consortium Publishes Phase II Map of Human Genetic Variation

New map improves power to find variants involved in common diseases; reveals more signs of human evolutionary history

The International HapMap Consortium today published analyses of its second-generation map of human genetic variation, which contains three times more markers than the initial version unveiled in 2005. In two papers in the journal Nature, the consortium describes how the higher resolution map offers greater power to detect genetic variants involved in common diseases, explore the structure of human genetic variation and learn how environmental factors, such as infectious agents, have shaped the human genome.

Cambridge scientists in world's first major genome screen for osteoarthritis

Cambridge scientists in world's first major genome screen for osteoarthritis

On World Arthritis Day (October 12) the Arthritis Research Campaign (arc) has announced plans to run a definitive genome-wide association study of osteoarthritis susceptibility called arcOGEN; the largest study of its kind ever undertaken.

The study will involve screening the DNA of 8,000 people suffering from osteoarthritis of the hip and knee and 6,000 unaffected people to compare the differences.

Researchers Expand Efforts to Explore Functional Landscape of the Human Genome

Researchers Expand Efforts to Explore Functional Landscape of the Human Genome

Full-Scale ENCODE Project Will Survey Entire Human Instruction Book

The Wellcome Trust Sanger Institute has been awarded $8.5M (£4.2M) by the US National Human Genome Research Institute (NHGRI) as part of a programme to expand the ENCyclopedia Of DNA Elements (ENCODE) project, which in its pilot phase yielded provocative new insights into the organization and function of the human genome.

Genes and disease? It's what you do with what you have

Genes and disease? It's what you do with what you have

The importance of gene regulation for common human disease

A new study published in Nature Genetics on Sunday 16 September 2007 show that common, complex diseases are more likely to be due to genetic variation in regions that control activity of genes, rather than in the regions that specify the protein code.

Leader in Human Genetics to join Wellcome Trust Sanger Institute

Leader in Human Genetics to join Wellcome Trust Sanger Institute

Professor Leena Peltonen Appointed Head of Human Genetics

Professor Peltonen, a member of the Finnish and the United States National Academy of Sciences, brings internationally recognized expertise in genetic studies of human disease to the Sanger Institute, a world leader in genomic and genetic research.

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