22 Dec 2006

Genome Program in the Top Three Computer Science Rankings

A Wellcome Trust Sanger Institute computer program to study genomes leads the world amongst scientists, a report published today reveals. The program is one of the freely available software tools developed by researchers at the Sanger Institute to accelerate the understanding of genomes.

10 Dec 2006

A hunt for the parasite genes that fool our defences

Today, a report led by the Wellcome Trust Sanger Institute details the weapons deployed by the parasite in this evolutionary arms race, and is published alongside two others in Nature Genetics. For the first time, we see how the genome of a clinical isolate is being shaped by the forces of our measures to battle malaria - a view that will reveal new areas to search for vaccine or drug targets.

24 Nov 2006

Evolution of typhoid bacteria

In a study published in the latest issue of Science (24 November, 2006), an international consortium from the Max-Planck Society, Wellcome Trust Institutes in Britain and Viet Nam, and the Institut Pasteur in France have elucidated the evolutionary history of Salmonella Typhi.

22 Nov 2006

New map of human genetic variation - International team identifies sites of copy number variation across all human chromosomes

A series of scientific studies published today show that it's not only single letters but sentences, paragraphs, and even whole pages that can be missing or duplicated. In the leading publication in Nature, an international team has produced a map of such changes among 270 copies of the human genetic code that is already revealing new routes for finding genes involved in disease.

3 Nov 2006

Wellcome Trust Sanger Institute cited for excellence

The Wellcome Trust Sanger Institute was heralded today by the Prime Minister, Tony Blair, for its work in decoding the human genome sequence - The Book of Life.

29 Oct 2006

Human Epigenome Project generates DNA methylation profiles of three chromosomes

A new DNA map, published in Nature Genetics today, provides the first large-scale study of biological inheritance in human that is not DNA-sequence based. The map of human chromosomes 6, 20 and 22 shows that as many as one in six of our human genes might be subject to modifications that could alter their activity by epigenetic changes - under the influence of the environment. Understanding these modifications will be important in diagnosis, drug development and disease study.

4 Oct 2006

Strategic focus on genetics

The Institute announced on 7 September its plans to focus its scientific efforts, identifying genetics as the area in which it can make the greatest - and a unique - contribution. This experimental focus will be concentrated on global studies of natural genetic variation in humans and pathogens, and experimental variation of genome sequence in the model organisms, mouse and zebrafish, as well as pathogens.

24 Sep 2006

Definitive resource for mapping of common immune system diseases

Leading causes of disability and death worldwide are today a step closer to being identified thanks to a new map of a vital region of the human genome, the Major Histocompatibility Complex (MHC). An international consortium has developed a detailed map of common variation in the MHC, a region that contains genes linked to common diseases such as diabetes and multiple sclerosis, as well as bestowing protection from pathogens and being vital in transplant medicine.

7 Sep 2006

Funding will generate new resources for biomedical discovery

The Wellcome Trust Sanger Institute today announces that it has been awarded funding by the prestigious US National Institutes of Health (NIH) to contribute to a consortium that will generate freely available genetic resources for biomedical research.

21 Jul 2006

Genetic interaction study identifies common modifiers of human disease genes

On Sunday 16 July 2006, in the online version of Nature Genetics, a team from the Wellcome Trust Sanger Institute described the complete mapping of interactions between 65,000 pairs of genes and identified a novel class of genes that play a role in many unrelated processes and so may play a role in many different diseases.