18 Dec 2003

International HapMap Project Starts the Cartography of Human Genome Variation

The quest to track down genes involved in health and disease and our response to treatments is a long and difficult challenge. Today (18th December 2003), in the journal Nature, the International HapMap Consortium, to which The Wellcome Trust is a major contributor, describes important new tools it will produce to enhance our use of the human genome sequence and to fast-track that quest.

3 Nov 2003

Wellcome Trust Sanger Institute completes two billion genetic letters

The Wellcome Trust Sanger Institute has broken a genetic decoding record on its tenth anniversary which could literally take it out of this world. The landmark completion of two billion letters of sequenced DNA will push biomedicine to a new level. It could also do that figuratively: if this DNA were scaled up to the size of a spiral staircase it would reach to the moon.

23 Oct 2003

Wellcome Trust Sanger Institute doubles gene count on chromosome 6

Is there a most valuable part of the human genome? Many corners could be argued, but a strong case can be made for part of chromosome 6, the complete sequence of which is published today by researchers from the Wellcome Trust Sanger Institute in the journal Nature. Chromosome 6, weighing in at more than 166 million chemical letters, or bases, of DNA, is the largest to be fully analysed to date.

15 Oct 2003

Construction of the extended Wellcome Trust Genome Campus reached a major milestone today [Wednesday October 15 2003], with completion of the concrete frame of the new laboratory accommodation which will house the Wellcome Trust Sanger Institute's new programmes of research activities.

Since completing the human genome sequence - as well as a host of other genomes - the focus of the Institute has been on understanding the messages in genes in order to improve the treatment of human disease.

7 Oct 2003

Epigenomics AG and The Wellcome Trust Sanger Institute announced today an agreement to fund and carry out the first phase of the Human Epigenome Project (HEP).

The HEP will identify and describe sites in the human genome at which cytosine bases are modified by DNA methylation (see Notes). This announcement follows the successful completion of the HEP pilot study funded by the European Union (FP5): the data from the pilot study are released today on the HEP's website.

14 Apr 2003

The International Human Genome Consortium today announced the successful completion of the Human Genome Project more than two years ahead of schedule.

The Wellcome Trust Sanger Institute, which was the only British organisation involved in the project, carried out nearly one-third of the work, making it the biggest contributor.*

21 Feb 2003

If you wanted to make sure you could hide while living amongst your enemies, what would you do? Learn to be a master of disguise and change your disguise frequently. Establish a seemingly intimate relationship with them. And not kill too many.

But now some of T. whipplei's secrets have been stripped bare by researchers working at the Wellcome Trust Sanger Institute in Cambridgeshire, and colleagues in the UK, the US and Germany and it is hoped this will help explain how other pathogens survive and proliferate.