News Archive - 2000

News Archive - 2000

Sanger Centre to sequence zebrafish genome in new Wellcome Trust Initiative

Sanger Centre to sequence zebrafish genome in new Wellcome Trust Initiative

Powerful model organism for genetics, development

With a genome only half the size of that of mouse or human, the zebrafish will play a key role in finding genes in the other genomes. The new project is predicted to take three years.

Public-Private Consortium to Accelerate Sequencing of Mouse Genome

Public-Private Consortium to Accelerate Sequencing of Mouse Genome

Results will expedite discovery of human genes

The National Institutes of Health, the Wellcome Trust and three private companies today announced they have formed a consortium to speed up the determination of the DNA sequence of the mouse genome. The Mouse Sequencing Consortium will provide $58 million over the next six months to decipher the mouse genetic code.

Wellcome Trust Announces Major Investment in Genome Bioinformatics

Wellcome Trust Announces Major Investment in Genome Bioinformatics

Five-year investment to support the Ensembl project, the database providing automatic annotation of the human genome

The increased resources in staff and computer power for the gene "software" will mean a much speedier collection and dissemination of information on the function of genes, greatly aiding the work of researchers around the world in finding new diagnostic methods and treatments for a huge variety of diseases.

Completion of draft human genome: press pack

Completion of draft human genome: press pack

Below are links to all the news releases and material created to announce the completion of the draft human genome

A wide range of supporting materials were created to supplement the main announcement of the draft human genome.

Human Genome Project Helps Identify Skin Disease Genes

Human Genome Project Helps Identify Skin Disease Genes

Dr. Alain Hovnanian is head of the Molecular Dermatology Unit at the Wellcome Trust Center for Human Genetics, Oxford. His team have been using the freely available DNA sequences from the Human Genome Project to identify the genes involved in three severe inherited skin disorders...

Using data from the human genome project and information from other databases, Dr Hovnanian's team identified 10 new genes and 4 known genes that were candidates for the disease gene. They then determined whether these genes were expressed in the skin and looked for mutations in those that were. To their surprise, they found that affected family members had defects in a gene that was previously known to function mainly in the heart and skeletal muscles. It turned out the protein the gene produced allows epidermal cells to maintain calcium stores, which are important for the function of desmosomes.

Human Genome Project Helps Child Birth Defects

Human Genome Project Helps Child Birth Defects

Pinpointing the 'bad' genes that lead to illness, deformity or a failure to develop normally, coupled with an understanding of how they work, has been facilitated by the Human Genome Project which is identifying the entire genetic code.

Scientists, like Professor Scambler, who are interested in medical conditions that children are born with are now able to 'database mine' the publicly available sequence data from the international Human Genome Project. In effect, the researchers look through the free-of-charge data as soon as it becomes available to try to identify the genes that may play a role in certain diseases.

The History of the UK Genome Project

The History of the UK Genome Project

1990 Drs Sulston and Coulson in collaboration with Dr Waterston (Washington University, USA) began a pilot study of the genomic sequence of the round worm C. elegans ...

Past Great Discoveries

Past Great Discoveries

Chronology of selected important events in medicine and biology

For context, some non-medical events are shown.

The Future's Genomic

The Future's Genomic

Genome sequencing could ultimately change the face of biology. More immediately, it is likely to change the way scientists conduct their research.

With the completion of the working draft of the human genome, the DNA letters (ACGT) that make up our 60 000-100 000 genes are in the public domain, freely accessible to all who want to interpret and exploit the sequence data.

Commentators' Views on the Announcement of the First Draft of the Human Genome

Commentators' Views on the Announcement of the First Draft of the Human Genome

Leading ethicists, geneticists, Government scientific advisors and the pharmaceutical industry give their perspectives on the effect the publication of the first draft of the human genome will have

Professor Richard Dawkins, Professo Martin Bobrow, Sir Robert May, Professor Sir David Weatherall, Steven Rose, Dr Tom Shakespeare, Professor Vivienne Nathanson, Bill Fullagar and Sir Aaron Klug, OM comment on the implications of the first draft human genome

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