News Archive

News Archive

Isolated Greek villages reveal genetic secrets that protect against heart disease

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Isolated Greek villages reveal genetic secrets that protect against heart disease

A genetic variant that protects the heart against cardiovascular disease has been discovered by researchers at the Wellcome Trust Sanger Institute and their collaborators.

The variant, rs145556679*, was associated with lower levels of both ‘bad’ natural fats – triglycerides – and ‘bad’ cholesterol – very low density lipoprotein cholesterol (VLDL). This cardioprotective variant may be almost unique to the Mylopotamos population.

Natural resistance to malaria linked to variation in human red blood cell receptors

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Natural resistance to malaria linked to variation in human red blood cell receptors

First study to identify protective effect of glycophorin gene rearrangements on malaria

Researchers have discovered that protection from the most severe form of malaria is linked with natural variation in human red blood cell genes. A study from the Wellcome Trust Sanger Institute, Wellcome Trust Centre for Human Genetics and their collaborators has identified a genetic rearrangement of red blood cell glycophorin receptors that confers a 40 per cent reduced risk from severe malaria.  Published in Science, this opens a new avenue of research for malarial therapeutics.

Scientists unveil the UK’s largest resource of human stem cells from healthy donors

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Scientists unveil the UK’s largest resource of human stem cells from healthy donors

Powerful resource created for scientists studying human development and disease

Reported in Nature, one of the largest sets of high-quality human induced pluripotent stem cell lines from healthy individuals has been produced by a consortium involving the Wellcome Trust Sanger Institute.  Comprehensively annotated and available for independent research, the hundreds of stem cell lines are a powerful resource for scientists studying human development and disease.

Cancer drug design targeted by COSMIC's new 3D system

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Cancer drug design targeted by COSMIC's new 3D system

Collaboration between Wellcome Trust Sanger Institute and Astex Pharmaceuticals brings together COSMIC (Catalogue of Somatic Mutations In Cancer) and wwPDB (worldwide Protein Data Bank) to visualise genomic and proteomic data on cancer mutations

COSMIC-3D, the most comprehensive system for exploring cancer mutations in three dimensions, is launched today by COSMIC, based at the Wellcome Trust Sanger Institute, in collaboration with Astex Pharmaceuticals, Cambridge, UK. With extensive colourful and helpful visualisations, the new resource can help identify and characterise drug targets as well as support the design of new therapeutics for cancer.

Dr Matt Hurles elected to the Academy of Medical Sciences

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Dr Matt Hurles elected to the Academy of Medical Sciences

Head of the Human Genetics Programme recognised with prestigious Fellowship

Dr Matt Hurles, Head of the Human Genetics Programme at the Wellcome Trust Sanger Institute is one of 46 world-leading scientists being honoured for their outstanding contribution to medical science by the Academy of Medical Sciences. Matt joins more than 1,100 existing Fellows whose innovative research has advanced understanding of health and disease and has been translated into benefits for society.

Genetics and environment combine to give everyone a unique sense of smell

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Genetics and environment combine to give everyone a unique sense of smell

Genetically identical mice develop different smell receptors in response to their environments

Researchers have shown that receptors in the noses of mice exposed to certain smells during life are different to genetically similar mice that lived without those smells. It is this combination of genetics and experience that gives each individual a unique sense of smell.

Mouse’s internal clock could reveal the secrets of ageing

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Mouse’s internal clock could reveal the secrets of ageing

Researchers have discovered that mice’s DNA ages in a similar way to humans

Published in Genome Biology, researchers at the Wellcome Trust Sanger Institute, Babraham Institute and the European Bioinformatics Institute reveal that mice have a similar epigenetic ageing clock to humans, providing a great laboratory model to explore how the clock works.

Some genes are less helpful than others

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Some genes are less helpful than others

Some people are naturally missing one of their 20,000 genes - and sometimes the results can be beneficial, pointing to new drug therapies

In an international collaboration published in Nature, researchers have identified individuals with natural gene-disrupting mutations - who have a gene that has been "knocked out" -  and systematically studied the biological consequences. The project provides a framework for using naturally-occurring genetic variation to gain vaulable insights into how individual genes affect health and disease.

New deep learning technique offers a more accurate approach to single-cell genomics

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New deep learning technique offers a more accurate approach to single-cell genomics

Scientists are using the emerging technology of deep learning to fill in the missing gaps of single-cell genomic analysis

A new ‘deep learning’ method, DeepCpG, has been designed by researchers at the Wellcome Trust Sanger Institute, the European Bioinformatics Institute and the Babraham Institute to help scientists better understand the epigenome – the biochemical activity around the genome. Reported today in Genome Biology, DeepCpG leverages ‘deep neural networks’, a multi-layered machine learning model inspired by the brain, and provides a valuable tool for research into health and disease. 

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