9 Nov 2015

Cancer and ageing could be predetermined by the speed of molecular clocks

A theory that our cells have molecular clock processes ticking inside them, that damage DNA by generating mutations continuously throughout life, has just been proven. These clock-like mutational processes could ultimately be responsible for a large proportion of human cancer and contribute to human ageing. Two clock-like mutational processes have been found in human cells and the rates at which the two clocks tick in different human cell types have been determined.

29 Oct 2015

Genomic fingerprint can highlight which breast, ovarian, pancreatic and gastric cancers are likely to respond to treatment

Gastric cancer, otherwise known as stomach cancer, does not respond well to existing treatments and it is currently the third leading cause of cancer death in the world (after lung and liver cancer). Researchers have discovered that certain drugs, currently used to treat breast, ovarian and pancreatic cancers, could also be used to treat certain gastric cancers with a particular pattern of mutations (genomic molecular fingerprint).

26 Oct 2015

Novel high-throughput approach finds combinations of genes that induce cancer

In a novel use of the CRISPR/Cas9 system, which can be deployed to switch genes off, researchers from Germany, the UK and Spain have developed a multiplexed screening approach to study and model cancer development in mice. The scientists mutated genes in the adult mouse liver uncovering their cancer-causing roles and determining which combinations of genes cooperate to cause liver cancer.

19 Oct 2015

Genetic similarity suggests Crohn's disease and ulcerative colitis form a continuum of subtypes in the bowel

A new understanding of inflammatory bowel diseases has been prompted by the analysis of genetic and clinical data from more than 30,000 patients. This study reveals that genetic factors affect the location of the inflammation in the gut, with implications for diagnosis and treatment of patients.

5 Oct 2015

Four new genetic disorders identified

The team behind the Deciphering Developmental Disorders (DDD) Study, one of the world's largest nationwide rare disease genome-wide sequencing initiatives, have developed a novel computational approach to identify genetic variants that cause disease in young children. This approach is only made possible by contrasting the DNA of children with severe developmental disorders of unknown genetic cause, with the DNA from individuals without overt developmental disorders. These research participants were drawn from around the globe.

2 Oct 2015

New genes found that regulate development of stem cells

The power of single-cell genomics is demonstrated in new research from the Wellcome Genome Campus, revealing how it could help scientists understand early development of cells. The study found new genes involved in stem cell regulatory networks and new subpopulations of cells, giving insights into stem cell pluripotency – the ability to develop into almost all different types of cell.

2 Oct 2015

Completed project creates largest catalogue of global genomic diversity

The 1000 Genomes Project has analysed the genomes of 2,504 individuals from around the world, creating the largest catalogue of global human genomic differences to date. This database of genetic diversity will help scientists understand the patterns of genetic variation in humans and support researchers who are using genetic methods to study why some people are susceptible to various diseases.

anopheles gambiae

1 Oct 2015

New resistance locus lies close to gatekeeper genes involved in malaria invasion of red blood cells

Variations in DNA at a specific location (or 'locus') on the genome that protect African children from developing severe malaria, in some cases nearly halving a child's chance of developing the life-threatening disease, have been identified in the largest genetic association study of malaria to date.

30 Sep 2015

Technology could help counter risk of next Ebola crisis

The Ebola crisis has highlighted a need to bolster global surveillance and enhance the capability to react appropriately to further outbreaks. Recent developments in technology could enable a swifter, more effective response to potentially deadly outbreaks of disease, a study has found. Disease detection, information sharing and pathogen genome data analysis could all be improved with the coordinated use of existing technology.

14 Sep 2015

Landmark study confirms complexity and informs the next stages of research

The largest population genome sequencing effort to date is published today in Nature. A series of papers describing resources and application of the data is published at the same time in Nature, Nature Genetics, Bioinformatics and Nature Communications.