Isolated Greek villages reveal genetic secrets that protect against heart disease
Natural resistance to malaria linked to variation in human red blood cell receptors
Researchers have discovered that protection from the most severe form of malaria is linked with natural variation in human red blood cell genes. A study from the Wellcome Trust Sanger Institute, Wellcome Trust Centre for Human Genetics and their collaborators has identified a genetic rearrangement of red blood cell glycophorin receptors that confers a 40 per cent reduced risk from severe malaria. Published in Science, this opens a new avenue of research for malarial therapeutics.
Scientists unveil the UK’s largest resource of human stem cells from healthy donors
Reported in Nature, one of the largest sets of high-quality human induced pluripotent stem cell lines from healthy individuals has been produced by a consortium involving the Wellcome Trust Sanger Institute. Comprehensively annotated and available for independent research, the hundreds of stem cell lines are a powerful resource for scientists studying human development and disease.
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Natural variation of Epstein-Barr virus genes, proteins and pri-miRNA (revised).
Journal of virology 2017
Application of rare variant transmission disequilibrium tests to epileptic encephalopathy trio sequence data.
European journal of human genetics : EJHG 2017
Integration of Tmc1/2 into the mechanotransduction complex in zebrafish hair cells is regulated by Transmembrane O-methyltransferase (Tomt).
Fifteen new risk loci for coronary artery disease highlight arterial-wall-specific mechanisms.
Nature genetics 2017
Epigenetic and Genetic Contributions to Adaptation in Chlamydomonas.
Molecular biology and evolution 2017
Resistance to malaria through structural variation of red blood cell invasion receptors.
Science (New York, N.Y.) 2017
Enhancing the genome editing toolbox: genome wide CRISPR arrayed libraries.
Scientific reports 2017;7;1;2244
Computational approaches for interpreting scRNA-seq data.
FEBS letters 2017
Reevaluation of SNP heritability in complex human traits.
Nature genetics 2017
A MILI-independent piRNA biogenesis pathway empowers partial germline reprogramming.
Nature structural & molecular biology 2017