Natural resistance to malaria linked to variation in human red blood cell receptors
Scientists unveil the UK’s largest resource of human stem cells from healthy donors
Reported in Nature, one of the largest sets of high quality human induced pluripotent stem cell lines from healthy individuals has been produced by a consortium involving the Wellcome Trust Sanger Institute. Comprehensively annotated and available for independent research, the hundreds of stem cell lines are a powerful resource for scientists studying human development and disease.
Cancer drug design targeted by COSMIC's new 3D system
COSMIC-3D, the most comprehensive system for exploring cancer mutations in three dimensions, is launched today by COSMIC, based at the Wellcome Trust Sanger Institute, in collaboration with Astex Pharmaceuticals, Cambridge, UK. With extensive colourful and helpful visualisations, the new resource can help identify and characterise drug targets as well as support the design of new therapeutics for cancer.
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Natural variation of Epstein-Barr virus genes, proteins and pri-miRNA (revised).
Journal of virology 2017
Application of rare variant transmission disequilibrium tests to epileptic encephalopathy trio sequence data.
European journal of human genetics : EJHG 2017
Integration of Tmc1/2 into the mechanotransduction complex in zebrafish hair cells is regulated by Transmembrane O-methyltransferase (Tomt).
Epigenetic and Genetic Contributions to Adaptation in Chlamydomonas.
Molecular biology and evolution 2017
Resistance to malaria through structural variation of red blood cell invasion receptors.
Science (New York, N.Y.) 2017
Enhancing the genome editing toolbox: genome wide CRISPR arrayed libraries.
Scientific reports 2017;7;1;2244
Computational approaches for interpreting scRNA-seq data.
FEBS letters 2017
Reevaluation of SNP heritability in complex human traits.
Nature genetics 2017
A MILI-independent piRNA biogenesis pathway empowers partial germline reprogramming.
Nature structural & molecular biology 2017