Phenotyping Data for Spns2 (MBNZ) Associated with 'vision/eye' (MP:0005391)

Eye Morphology: Eye Morphology v2 - significant parameters
Eye Morphology (week 15) [Mice were fed on High Fat Diet (21.4% crude fat content, Western RD, 829100, Special Diets Services) from 4 weeks of age]: Mice are assessed for gross morphological changes to the eye using a slit lamp (Zeiss SL130) and ophthalmoscope (Heine Omega 500). The eye is examined both undilated and dilated (tropicamide and/or neosynephrine). Images on the slit lamp are collected using a Leica DFC420. Images of the fundus are collected by using a topical endoscope (BERCI Tele-Otoscope with HOPKINS straight forward 0?, diameter 3mm, Halogen cold light fountain light source) and camera (Nikon D40x with Nikon AF 85mm F1.8D AF Nikkor lens).
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Test complete and data/resources are available Test is complete and the data are considered interesting Preliminary indication of an interesting phenotype
Test is complete but the data are not considered interesting Test not performed or applicable Test pending
Test abandoned
Parameter Female
Hom
Male
Hom
population
parameter
Graph MP Annotation
Eyes Bulging
Eyelid Closure view graph MP:0005176 - eyelids fail to open
MP:0005287 - narrow eye opening
Cornea view graph MP:0001312 - abnormal cornea morphology
Cornea Opacity view graph MP:0001314 - corneal opacity
Pupil
Pupil Position
Pupil Shape view graph MP:0001317 - abnormal pupil morphology
Pupil Dilation
Lens
Lens Opacity (non suture or snowflake)
Right Retina
Left Retina
Right Retina Structure
Left Retina Structure
Left eye Bergmeister's Papilla
Right eye Bergmeister's Papilla
Dysmorphology: Dysmorphology - significant parameters
Dysmorphology (week 10) [Mice were fed on High Fat Diet (21.4% crude fat content, Western RD, 829100, Special Diets Services) from 4 weeks of age]: Whole body morphology is examined using a standardised checklist. The coat and whiskers are examined using a standardised checklist at a separate time point (week 4). Hair follicle cycling is assessed at approximately 43 days of age. It is considered normal that, at this age, the mouse has exited anagen phase.
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Test complete and data/resources are available Test is complete and the data are considered interesting Preliminary indication of an interesting phenotype
Test is complete but the data are not considered interesting Test not performed or applicable Test pending
Test abandoned
Parameter Female
Hom
Male
Hom
population
parameter
Graph MP Annotation
Eyes
Eye Colouration view graph MP:0009859 - eye opacity [mp:0009859]
Eye Size
Eye Histopathology: Standard Protocol - significant parameters
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Legend - hover over each heading to get a more complete description
Test complete and data/resources are available Test is complete and the data are considered interesting Preliminary indication of an interesting phenotype
Test is complete but the data are not considered interesting Test not performed or applicable Test pending
Test abandoned
Parameter population
parameter
Graph MP Annotation
Eye Histopathology MP:0001297 - abnormal anterior chamber angle
MP:0001304 - abnormal ciliary body morphology
MP:0001306 - abnormal corneal stroma morphology
MP:0001314 - abnormal iris morphology
MP:0001322 - abnormal retina morphology
MP:0001325 - cataract
MP:0004221 - corneal opacity
MP:0005099 - microphthalmia
MP:0005300 - small lens