Phenotyping Data for Lrig1 (MBHE) Associated with 'integument' (MP:0010771)

Dysmorphology: Hair Analysis
Hair Analysis (week 4) [Mice were fed on Mouse Breeder Diet (5021, Labdiet) up to 4 weeks of age]: The coat and whiskers are examined using a standardised checklist.
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Test complete and data/resources are available Test is complete and the data are considered interesting Preliminary indication of an interesting phenotype
Test is complete but the data are not considered interesting Test not performed or applicable Test pending
Test abandoned
Parameter Female
Hom
Male
Hom
population
parameter
Graph MP Annotation
Guard Hairs
Dorsal Coat
Dorsal Coat Long
Dorsal Coat Short
Dorsal Coat Rough
Dorsal Coat Sparse
Dorsal Coat Coarse
Dorsal Coat Fine
Dorsal Coat Skin Visible
Ventral coat
Ventral Coat Long
Ventral Coat Short
Ventral Coat Rough
Ventral Coat Sparse
Ventral Coat Coarse
Ventral Coat Fine
Ventral Coat Skin Visible
Hair Behind Ears
Hair On Tail
Tail Tip Hairs
Vibrissae
Vibrissae Short
Vibrissae Long
Vibrissae Curly
Vibrissae Disorientated
Vibrissae Absent
Dysmorphology: Hair Follicle Cycling
Hair Follicle Cycling (approximately 43 days of age) [Mice were fed on High Fat Diet (21.4% crude fat content, Western RD, 829100, Special Diets Services) from 4 weeks of age]: Hair follicle cycling, assessed by examining skin pigmentation, should be synchronised at ~6 weeks. It is considered normal at this age for the mouse to have entered catagen phase.
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Test complete and data/resources are available Test is complete and the data are considered interesting Preliminary indication of an interesting phenotype
Test is complete but the data are not considered interesting Test not performed or applicable Test pending
Test abandoned
Parameter Female
Hom
Male
Hom
population
parameter
Graph MP Annotation
Anagen Phase
Dysmorphology: Dysmorphology - significant parameters
Dysmorphology (week 10) [Mice were fed on High Fat Diet (21.4% crude fat content, Western RD, 829100, Special Diets Services) from 4 weeks of age]: Whole body morphology is examined using a standardised checklist. The coat and whiskers are examined using a standardised checklist at a separate time point (week 4). Hair follicle cycling is assessed at approximately 43 days of age. It is considered normal that, at this age, the mouse has exited anagen phase.
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Test complete and data/resources are available Test is complete and the data are considered interesting Preliminary indication of an interesting phenotype
Test is complete but the data are not considered interesting Test not performed or applicable Test pending
Test abandoned
Parameter Female
Hom
Male
Hom
population
parameter
Graph MP Annotation
Skin Pigmentation
Skin Condition view graph MP:0001191 - abnormal skin condition
MP:0001192 - scaly skin
Coat Colouration
Coat Texture
Forepaw Nails
Coat Intact
Whiskers
Hindlimb Foot Pads
Hindlimb Nails
Skin Histopathology: Standard Protocol - significant parameters
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Test complete and data/resources are available Test is complete and the data are considered interesting Preliminary indication of an interesting phenotype
Test is complete but the data are not considered interesting Test not performed or applicable Test pending
Test abandoned
Parameter population
parameter
Graph MP Annotation
Skin Histopathology MP:0008861 - abnormal hair shedding
Tail Epidermis Wholemount: Standard Protocol - significant parameters
Tail Epidermis Whole mount Collaboration (week 16) [Mice were fed on Mouse Breeder Diet (5021, Labdiet) from weaning]: Whole mount preparations of tail epidermis are prepared essentially as described by Braun et al (Development 130:5241-5255, 2003). Whole mounts are labeled with antibodies to keratin 14 (red) and keratin 15 (green), and counter-stained with DAPI to reveal cell nuclei (blue). Keratin 14 is expressed by undifferentiated cells in the hair follicles, sebaceous glands and interfollicular epidermis. Keratin 15 is expressed by the reservoir of stem cells in the hair follicle bulge. This phenotyping collaboration is performed with Fiona Watt and colleagues at the Cambridge Research Institute.
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Legend - hover over each heading to get a more complete description
Test complete and data/resources are available Test is complete and the data are considered interesting Preliminary indication of an interesting phenotype
Test is complete but the data are not considered interesting Test not performed or applicable Test pending
Test abandoned
Parameter population
parameter
Graph MP Annotation
Tail Epidermis Wholemount MP:0000384 - abnormal epidermis stratum basale morphology
MP:0001231 - distorted hair follicle pattern