Browsing Data by Mammalian Phenotype: 'skeleton'

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Browsing Data by Mammalian Phenotype: 'skeleton'

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Sytl1

Datasets: Gene Details WTSI Phenotyping Mice IKMC Vectors and ES Cells DNA Clone Resources

Sytl1 was found for the following reasons:

mp_id	-	MP:0005390
MP	-	MP:0005390
mp_ontology	-	MP:0000001 \| MP:0005390 \| MP:0005508 \| MP:0002114 \| MP:0004703 \| MP:0000137 \| MP:0003036
mp	-	MP:0005390

Gene Details

Marker Name(s):	synaptotagmin-like 1 view this gene in MGI
Marker Type:	protein coding gene
Synonyms:	PSGL-1, Slp1
Location:	Chr4:133253090-133263113(-)

Related Human Conditions (from OMIM) - no related Human Condition

More Information

MGI Gene Accession:	MGI:1933365	Ensembl Gene ID:	ENSMUSG00000028860	Vega Gene ID:	OTTMUSG00000010476
Entrez Gene ID:	269589	CCDS ID:

Interpro Families

Orthologs / Homologs

Species	Marker Symbol	Entrez Gene ID	Ensembl Gene ID
Human	SYTL1	84958
Rat	Sytl1	297872

view original data

Data provided by Mouse Genome Informatics (MGI), Ensembl

WTSI Phenotyping

MP Ontology Based Heatmap

Allele Name	Colony Prefix	Colony Strain	adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary	embryogenesis	endocrine/exocrine gland	growth/size	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	other	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	tumorigenesis	vision/eye
Sytl1^{tm1a(KOMP)Wtsi}	MBPB	C57BL/6Brd-Tyr^c-Brd;C57BL/6N

Legend:

No Raw Data

No Significant Annotations

Significant Annotation Present

Link to a test report page

About This Heatmap

This heatmap is built up of top-level terms from the MP (Mammalian Phenotype) ontology. We have mapped a majority of the parameters in our tests to appropriate MP terms, so when we perform a given test we can say if it should be annotated with the given MP term (if the phenotype is significant). This is what you see in this heatmap - if a significant result has been annotated to a top-level MP term (or any of its children), the cell will be red, if the result was not significant, the cell will be blue.

Please Note: as mentioned above we do not annotate all of our phenotyping tests to the MP ontology. The tests that are excluded are: 'Adult LacZ Expression', 'Brain/Eye/Skin Histopathology', 'Embryo LacZ Expression', 'Fertility', 'Heart Histology', 'Micronuclei', 'MicroCT & Quantitative Faxitron', 'Plasma Immunoglobulins', 'Prepulse Inhibition', 'Recessive Lethal Study', 'Tail Epidermis Wholemount', 'Tissue Biobank' and 'Viability at Weaning'. You can find our results for these tests in the 'Phenotyping Test Based Heatmap' below.

Phenotyping Test Based Heatmap

Allele Name	Colony Prefix	Colony Strain	Viability at weaning	Recessive Lethal Study	Fertility	Embryo LacZ Expression	Adult LacZ Expression	General Observations	Weight Curves	Open Field	Modified SHIRPA	Grip Strength	Hot Plate	Dysmorphology	Rotarod	Non-Invasive Blood Pressure	Prepulse Inhibition	Indirect Calorimetry	Glucose Tolerance (ip)	Auditory Brainstem Response	Body Composition (DEXA)	X-ray Imaging	Stress Induced Hyperthermia	Eye Morphology	Plasma Chemistry	Plasma Immunoglobulins	Haematology (CBC)	Peripheral Blood Lymphocytes	Micronuclei	Tissue Biobank	Heart Weight	Heart Histology	Tail Epidermis Wholemount	Skin Histopathology	Brain Histopathology	Eye Histopathology	MicroCT & Quantitative Faxitron	Salmonella Challenge	Citrobacter Challenge
Sytl1^{tm1a(KOMP)Wtsi}	MBPB	C57BL/6Brd-Tyr^c-Brd;C57BL/6N

download a spreadsheet containing all WTSI phenotyping data

Legend - hover over each heading to get a more complete description
	Test complete and data/resources are available	Test is complete and the data are considered interesting	Preliminary indication of an interesting phenotype
	Test is complete but the data are not considered interesting	Test not performed or applicable	Test pending
	Test abandoned	Link to a test report page	Link to a pdf report

view original data

Data provided by The Wellcome Trust Sanger Institute (WTSI)

Mice

Allele Name

Allele Type

EMMA ID

Colony Prefix

ES Cell/Common Name

Genetic Background

QC/Screening Data

MI/Distribution Centre

contact distributor

Sytl1^{tm1a(KOMP)Wtsi}

Knockout-First - Reporter Tagged Insertion (Promotor Driven Cassette)

MBPB

EPD0084_1_C03

C57BL/6Brd-Tyr^c-Brd;C57BL/6N

view data
( about )

WTSI/UCD

Southern Blot	na	TV Backbone Assay	pass	5' LR-PCR	pass
Loss of WT Allele (LOA) qPCR	na	Homozygous Loss of WT Allele (LOA) SR-PCR	pass	Neo Count (qPCR)	pass
LacZ SR-PCR	pass	5' Cassette Integrity		Neo SR-PCR	na
Mutant Specific SR-PCR	pass	LoxP Confirmation	pass	3' LR-PCR	na
Genotyping Comment

view original data

Data provided by The International Knockout Mouse Consortium (IKMC)

IKMC Vectors and ES Cells

	Vectors	ES Cells
KOMP-CSD (Project: 24113)	order	order	view details

ES Cell Clones

Cassette Type

5 Knockout-First Alleles

0 Targeted Non-Conditional Alleles

Promotor Driven

Allele:	genbank file \| image
Targeting Vector:	genbank file \| image

Targeting Vector:

genbank file | image

view all available ES cell clones

ES Cell Clones With Conditional Potential

ES Cell Clone

Targeting Vector

ES Cell Strain

ES Cell Line

Allele

Allele Type

QC/Screening Data

EPD0084_1_B04

PRPGS00052_A_C05

C57BL/6N

JM8.F6

tm1a(KOMP)Wtsi

Knockout-First - Reporter Tagged Insertion (Promotor Driven Cassette)

view data ( about )

Production Centre
5' Screen	not attempted	LoxP Screen	pass	3' Screen	pass
Loss of WT Allele (LOA)	-	Vector Integrity	-

Distribution Centre
Karyotype	0.9 - 0.81	Copy Number	-	Cells Thawed Correctly	-
5' LR-PCR	pass	5' SR-PCR	-	3' SR-PCR	pass
LOA	-	LOXP	-	LACZ	-
Chromosome 1	-	Chromosome 8a	-	Chromosome 8b	-
Chromosome 11a	-	Chromosome 11b	-	Chromosome Y	-

User/Mouse Clinic
Southern Blot	-	Map Test	-	Karyotype	-
TV Backbone Assay	-	5' LR-PCR	-	Loss of WT Allele (LOA)	-
Neo Count (qPCR)	-	LacZ SR-PCR	-	5' Cassette Integrity	-
Neo SR-PCR	-	Mutant Specific SR-PCR	-	LoxP Confirmation	-
3' LR-PCR	-

EPD0084_1_C03

PRPGS00052_A_C05

C57BL/6N

JM8.F6

tm1a(KOMP)Wtsi

Knockout-First - Reporter Tagged Insertion (Promotor Driven Cassette)

view data ( about )

Production Centre
5' Screen	not attempted	LoxP Screen	pass	3' Screen	pass
Loss of WT Allele (LOA)	-	Vector Integrity	-

Distribution Centre
Karyotype	-	Copy Number	-	Cells Thawed Correctly	-
5' LR-PCR	-	5' SR-PCR	-	3' SR-PCR	-
LOA	-	LOXP	-	LACZ	-
Chromosome 1	-	Chromosome 8a	-	Chromosome 8b	-
Chromosome 11a	-	Chromosome 11b	-	Chromosome Y	-

User/Mouse Clinic
Southern Blot	-	Map Test	-	Karyotype	-
TV Backbone Assay	-	5' LR-PCR	-	Loss of WT Allele (LOA)	-
Neo Count (qPCR)	-	LacZ SR-PCR	-	5' Cassette Integrity	-
Neo SR-PCR	-	Mutant Specific SR-PCR	-	LoxP Confirmation	-
3' LR-PCR	pass

EPD0084_1_C04

PRPGS00052_A_C05

C57BL/6N

JM8.F6

tm1a(KOMP)Wtsi

Knockout-First - Reporter Tagged Insertion (Promotor Driven Cassette)

view data ( about )

Production Centre
5' Screen	not attempted	LoxP Screen	pass	3' Screen	pass
Loss of WT Allele (LOA)	-	Vector Integrity	-

Distribution Centre
Karyotype	-	Copy Number	-	Cells Thawed Correctly	-
5' LR-PCR	-	5' SR-PCR	-	3' SR-PCR	-
LOA	-	LOXP	-	LACZ	-
Chromosome 1	-	Chromosome 8a	-	Chromosome 8b	-
Chromosome 11a	-	Chromosome 11b	-	Chromosome Y	-

User/Mouse Clinic
Southern Blot	-	Map Test	-	Karyotype	-
TV Backbone Assay	-	5' LR-PCR	-	Loss of WT Allele (LOA)	-
Neo Count (qPCR)	-	LacZ SR-PCR	-	5' Cassette Integrity	-
Neo SR-PCR	-	Mutant Specific SR-PCR	-	LoxP Confirmation	-
3' LR-PCR	-

EPD0084_1_D04

PRPGS00052_A_C05

C57BL/6N

JM8.F6

tm1a(KOMP)Wtsi

Knockout-First - Reporter Tagged Insertion (Promotor Driven Cassette)

view data ( about )

Production Centre
5' Screen	not attempted	LoxP Screen	pass	3' Screen	pass
Loss of WT Allele (LOA)	-	Vector Integrity	-

Distribution Centre
Karyotype	-	Copy Number	-	Cells Thawed Correctly	-
5' LR-PCR	-	5' SR-PCR	-	3' SR-PCR	-
LOA	-	LOXP	-	LACZ	-
Chromosome 1	-	Chromosome 8a	-	Chromosome 8b	-
Chromosome 11a	-	Chromosome 11b	-	Chromosome Y	-

User/Mouse Clinic
Southern Blot	-	Map Test	-	Karyotype	-
TV Backbone Assay	-	5' LR-PCR	-	Loss of WT Allele (LOA)	-
Neo Count (qPCR)	-	LacZ SR-PCR	-	5' Cassette Integrity	-
Neo SR-PCR	-	Mutant Specific SR-PCR	-	LoxP Confirmation	-
3' LR-PCR	-

EPD0084_1_F02

PRPGS00052_A_C05

C57BL/6N

JM8.F6

tm1a(KOMP)Wtsi

Knockout-First - Reporter Tagged Insertion (Promotor Driven Cassette)

view data ( about )

Production Centre
5' Screen	not attempted	LoxP Screen	pass	3' Screen	pass
Loss of WT Allele (LOA)	-	Vector Integrity	-

Distribution Centre
Karyotype	-	Copy Number	-	Cells Thawed Correctly	-
5' LR-PCR	-	5' SR-PCR	-	3' SR-PCR	-
LOA	-	LOXP	-	LACZ	-
Chromosome 1	-	Chromosome 8a	-	Chromosome 8b	-
Chromosome 11a	-	Chromosome 11b	-	Chromosome Y	-

User/Mouse Clinic
Southern Blot	-	Map Test	-	Karyotype	-
TV Backbone Assay	-	5' LR-PCR	-	Loss of WT Allele (LOA)	-
Neo Count (qPCR)	-	LacZ SR-PCR	-	5' Cassette Integrity	-
Neo SR-PCR	-	Mutant Specific SR-PCR	-	LoxP Confirmation	-
3' LR-PCR	-

ES Cell Clones Without Conditional Potential

No clones available.

Targeting Vectors

Design	Targeting Vector	Intermediate Vector	Cassette	Backbone	Targeting Vector Genbank File
44240	PRPGS00052_A_C05	PCS00052_A_C05	L1L2_Bact_P	L4L3_pD223_DTA_spec	view

view original data

Data provided by The International Knockout Mouse Consortium (IKMC)

DNA Clone Resources

C57Bl/6J Bacs	129 Bacs	MICER clones	KO Targeting Vectors
23	6	1	1	view in Ensembl

view original data

Data provided by The Wellcome Trust Sanger Institute (WTSI)

Tcf4	Datasets: Gene Details WTSI Phenotyping Mice IKMC Vectors and ES Cells DNA Clone Resources

Tcf4 was found for the following reasons:

mp_id	-	MP:0005390
MP	-	MP:0005390
mp_ontology	-	MP:0000001 \| MP:0005390 \| MP:0005508 \| MP:0002932
mp	-	MP:0005390