Enter gene/product identifiers or phenotyping test names (e.g. Mysm1, EPD0019_1_A05 or Dexa) or any other search term described in the help section.

About This Portal

The Wellcome Trust Sanger Institute generates, characterises, and uses a variety of reagents for mouse genetics research. It also aims to facilitate the distribution of these resources to the external scientific community. Here, you will find unified access to the different resources available from the Institute or its collaborators. The resources include: 129S7 and C57BL6/J bacterial artificial chromosomes (BACs), MICER gene targeting vectors, knock-out first conditional-ready gene targeting vectors, embryonic stem (ES) cells with gene targeted mutations or with retroviral gene trap insertions, mutant mouse lines, and phenotypic data generated from the Institute's primary screen.

Phenotyping Summary

The table below displays the number of alleles that have completed different stages of the MGP Phenotyping pipeline (funded by WTSI & EUMODIC)

Comprehensive Phenotyping Substantively Complete 680
Infection Challenge (Salmonella and Citrobacter) 543
LacZ Expression (Adult and E14.5) 341

Other Data Summary

The table below displays the number of unique genes with each individual product type produced at the Wellcome Trust Sanger Institute.

Funding: WTSI
EUMODIC 		KOMP
EUCOMM 		KOMP
EUCOMM 		WT WT WT
Products: Mice Targeted ES Cells Gene Targeting Vectors MICER C57Bl/6J BACs 129S7 BACs
1053 13073 15305 9076 17175 16824

Phenotyping Overview

Download the Phenotyping Overview Download a heat map of phenotyping results by assay. This spreadsheet also links to the detailed phenotyping data on this portal.

NEW - Disease predictions based on semantic similarity between OMIM disorder clinical features and model organism phenotypes.
Sign up to our mailing list to be alerted of new data If you would like to be kept updated with information on our phenotyping data, please subscribe to our mailing list.

Phenotyping Raw Data Access

Raw phenotyping data can be accessed and searched using the MGP Phenotyping BioMart.

Help files

pdf img How to extract raw phenotyping data. pdf img How to extract summary ontology calls.
pdf img How to search gene expression data. pdf img How to search by gene.
pdf img How to search by mammalian phenotyping ontology term. pdf img How to view a summary of all phenotyping data.

Viewing Our Data in Ensembl

Most of the products found within this portal can also be viewed as DAS tracks in the Ensembl genome browser. Follow these links to have the tracks automatically activated for you:

Publications

Karp, Natasha A., Anne Segonds-Pichon, Anna-Karin B. Gerdin, Ramiro Ramírez-Solis, and Jacqueline K. White. "The fallacy of ratio correction to address confounding factors." Laboratory Animals 46, no. 3 (2012): 245-252. pmid

Gerdin, Anna-Karin, Natalia Igosheva, Laura-Anne Roberson, Ozama Ismail, Natasha Karp, Mark Sanderson, Emma Cambridge et al. "Experimental and husbandry procedures as potential modifiers of the results of phenotyping tests." Physiology & behavior (2012). pmid

Nijnik, Anastasia, Simon Clare, Christine Hale, Jing Chen, Claire Raisen, Lynda Mottram, Mark Lucas et al. "The Role of Sphingosine-1-Phosphate Transporter Spns2 in Immune System Function." The Journal of Immunology 189, no. 1 (2012): 102-111. pmid

Karp, Natasha A., Lauren A. Baker, Anna-Karin B. Gerdin, Niels C. Adams, Ramiro Ramírez-Solis, and Jacqueline K. White. "Optimising experimental design for high-throughput phenotyping in mice: a case study." Mammalian genome 21, no. 9 (2010): 467-476. pmid

Morgan, Hugh, Tim Beck, Andrew Blake, Hilary Gates, Niels Adams, Guillaume Debouzy, Sophie Leblanc et al. "EuroPhenome: a repository for high-throughput mouse phenotyping data." Nucleic acids research 38, no. suppl 1 (2010): D577-D585. pmid

Ramírez‐Solis, Ramiro, Edward Ryder, Richard Houghton, Jacqueline K. White, and Joanna Bottomley. "Large‐scale mouse knockouts and phenotypes." Wiley Interdisciplinary Reviews: Systems Biology and Medicine (2012). pmid

Migdalska, Anna M., Louise van der Weyden, Ozama Ismail, Jacqueline K. White, Gabriela Sánchez-Andrade, Darren W. Logan, Mark J. Arends, and David J. Adams. "Modeling Partial Monosomy for Human Chromosome 21q11. 2-q21. 1 Reveals Haploinsufficient Genes Influencing Behavior and Fat Deposition." PloS one 7, no. 1 (2012): e29681. pmid

Bassett, JH Duncan, Apostolos Gogakos, Jacqueline K. White, Holly Evans, Richard M. Jacques, Anne H. van der Spek, Ramiro Ramirez-Solis et al. "Rapid-Throughput Skeletal Phenotyping of 100 Knockout Mice Identifies 9 New Genes That Determine Bone Strength." PLoS Genetics 8, no. 8 (2012): e1002858. pmid

van der Weyden, Louise, Jacqueline K. White, David J. Adams, and Darren W. Logan. "The mouse genetics toolkit: revealing function and mechanism." Genome biology 12, no. 6 (2011): 224. pmid

Migdalska, Anna M., Louise van der Weyden, Ozama Ismail, Alistair G. Rust, Mamunur Rashid, Jacqueline K. White, Gabriela Sánchez-Andrade et al. "Generation of the Sotos syndrome deletion in mice." Mammalian Genome (2012): 1-9. pmid

Nijnik, Anastasia, Simon Clare, Christine Hale, Claire Raisen, Rebecca E. McIntyre, Kosuke Yusa, Aaron R. Everitt et al. "The critical role of histone H2A-deubiquitinase Mysm1 in hematopoiesis and lymphocyte differentiation." Blood 119, no. 6 (2012): 1370-1379. pmid

Ayadi, Abdel, Marie-Christine Birling, Joanna Bottomley, James Bussell, Helmut Fuchs, Martin Fray, Valérie Gailus-Durner et al. "Mouse large-scale phenotyping initiatives: overview of the European Mouse Disease Clinic (EUMODIC) and of the Wellcome Trust Sanger Institute Mouse Genetics Project." Mammalian Genome (2012): 1-11. pmid

Funding for the generation and archiving of mouse lines by the Sanger Institute was provided by

  • the Wellcome Trust (grant [098051])
  • the National Institutes of Health (KOMP; awards [UO1-HG004080]; [1-U42RR033192])
  • the European Commission
    • EUMODIC (contract [LSHG-CT-2006-037188])
    • EMMAService (grant [227490])
    • Infrafrontier-I3 (grants [211404]; [312325])
    • EUCOMMTools (grant [261492])
Get in Touch

Get in Touch

For enquiries about the data displayed in this portal (or requests for further information), please contact MGPEnquiries@sanger.ac.uk.

For enquiries about access to mouse lines, please contact mouseinterest@sanger.ac.uk.

If you have any problems/comments with regards to this portal, or would like to request a new feature please send an email to mouseportal@sanger.ac.uk, we'd like to hear from you!