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COSMIC mutation id for this mutation. Can search by mutation id on COSMIC homepage.
Type can be either "Inferred Breakpoint" or "Observed mRNA". Explanation of the two terms can be found in the Translocation Overview help page.
Syntax format describing the portions of mRNA PRESENT (in HGVS "r." format) from each gene (allows representation of UTR sequences). This is a one line syntax, explanation and examples below:
Using TMPRSS2/ERG as an example.
1. Standard Fusion:
2. Fusion to the complimentary strand (flipped fusion):
("o" signifies antisense orientation)
Lists the genes involved in the fusion. Each gene name is a clickable link to the Gene Summary page for that gene
Inferred Breakpoint/Observed mRNA
Diagramatic representation of the selected mutation. Can either be Inferred Breakpoint, or Observed mRNA. Shows the transcripts of each of the 2 genes (in red and blue) aligned with the transcript resulting from the fusion event (in the middle)
Observed mRNA(s)/Inferred Breakpoint(s)
Diagramatic representation of either all the inferred breakpoints for a selected mRNA transcript mutation, or as in this case, all the observed mRNA transcripts for a selected inferred breakpoint mutation
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