Cancer Genome Project

For more information on these study sets, visit:
Protein Kinases	Pilot Matched Pair Cell Line Set	Renal Matched Pair Tumour Set

Summary

These data are derived from CGP in-house screening of genes for somatic mutations in both matched-pair cell lines and in primary tumours. All mutations are verified somatic.

Data are released on a bi-monthly basis with verified and annotated mutations accrued in the preceding two months being released in each cycle.

For ease of viewing/navigation, genes are organised into categories according to general families and functions.

Protein Kinase Data

View the results	SNP array data	Progress	Additional Mutations
Breast	SNP array data	Reference	Mutations
Lung	SNP array data	Reference	Mutations
Testis	SNP array data	Reference	Mutations
Glioma	SNP array data	Reference	Mutations
Gastric	SNP array data	Reference
Colorectal	SNP array data	Reference	Mutations
Ovarian	SNP array data	Reference
Renal	SNP array data	Reference
ALL (Acute lymphoblastic leukaemia)	SNP array data	Reference
Matched Pair Cancer Cell Lines	SNP array data	Reference

Pilot Matched Pair Cancer Cell Line Data

Study	Genes	Mutations
ADAM metallopeptidase family	40	43
Apobec family	8	0
Apoptosis genes	179	100
Arachidonate metabolism and phospholipase A2 family	14	1
Chemokine (C-X-C motif) ligand	9	0
Chromosome X	839	195
C-X-C/C-C motif chemokine receptor genes	19	8
Cyclins and genes associated with RB	68	25
Cyclooxygenase family	6	0
Cytochrome C oxidase family	23	3
DEAD box proteins	57	27
Diacylglycerol kinases and other lipid kinases	18	17
DNA damage response and repair	203	125
DNA methylation and histone deacetylation	39	16
DNA repair genes	354	221
DNA replication	85	50
Downstream of kinase family	4	0
Dual specificity phosphatases	23	2
Essential For Cell Division - derived from a siRNA screen in human cells	21	5
Ets transcription factor family	28	7
FK506/rapamycin binding protein family	25	5
Forkhead transcription factor family	42	12
GAP-GEF genes	173	106
Genes associated with ERB family of RTKs	8	3
Genes associated with MYC proteins	21	13
Genes associated with RAS proteins	53	14
Genes associated with TP53 and targets	47	20
Genes found in translocated regions	131	23
Genes from RNAi TSG gene screen	5	2
Genes implicated in stem cell regulation	65	17
Genes in amplified regions, internal CGP data	200	90
Genes on APC/CTNNB1 pathway	66	40
Glycolysis associated genes	23	5
Growth Arrest Specific Genes	7	1
Heat shock proteins	76	24
Heterotrimeric G-Proteins	34	6
High mobility group proteins - DNA binding	18	3
Histone acetyltransferase	7	2
Human homologues of Mouse Retrovirus Tagged Cancer Genes	190	67
Human homologues of putative target cancer genes from transposon screens in the mouse	14	39
Hypoxia inducible factor pathway	23	12
Immediate early/regulator of G-protein signalling family	25	8
Inositol Polyphosphate Phosphatases	15	12
Integrin alpha family	16	15
Integrin beta family	8	10
Integrin binding proteins	27	5
Kallikrein protease family	16	5
K homology RNA-binding domain, type I	24	14
Lamin protein family	5	1
Matrix metallopeptidase family	21	8
Miscellaneous genes of interest from literature sources	92	19
Mps One Binder kinase activator-like	5	0
Nfkappa signalling family	59	14
Notch signalling proteins	55	32
Nuclear receptors and cofactors	39	62
Nucleocytoplasmic transport components	61	38
Nucleotide metabolism	35	11
PAX transcription factor family	11	5
Phosphatidylinositol metabolism	90	42
Phospholipase C family	13	16
Phospholipase D family	5	0
Protein kinase anchor proteins	32	19
Protein Tyrosine Phosphatases (PTP)	51	41
Ral guanine nucleotide dissociation factors	6	3
SCF and APC cell cycle control complex components	99	34
Serpin/TIMP peptidase inhibitor families	44	17
SerThr Phosphatases (PPP)	69	20
Sirtuin family of proteins, homologs to the yeast Sir2 protein	7	0
SMAD protein family	22	7
Small monomeric GTPases	140	28
Small ubiquitin-like modifier (SUMO) protein family	14	5
Sorting NeXin family	27	5
Splicing factor, arginine/serine-rich (SR) family	10	0
STAT and SOCS gene families	43	10
SWI/SNF	16	20
TCA cycle genes	56	19
Telomerase complex	14	15
TP53 responsive genes	76	31
Tripartite motif-containing protein family	52	29
Ubiquitination pathway genes	63	21
Ubiquitin ligases	72	41
Ubiquitin specific peptidase family	50	18
14_3_3 family of scaffold protein	8	1

Renal Matched Pair Tumour Set Data

Study	Genes	Mutations
ADAM metallopeptidase family	40	4
Apobec family	8	0
Apoptosis genes	183	5
Arachidonate metabolism and phospholipase A2 family	14	0
Chemokine (C-X-C motif) ligand	9	0
C-X-C/C-C motif chemokine receptor genes	19	0
Cyclins and genes associated with RB	68	2
Cyclooxygenase family	6	0
Cytochrome C oxidase family	23	0
DEAD box proteins	57	4
Diacylglycerol kinases and other lipid kinases	18	2
DNA methylation and histone deacetylation	39	0
DNA repair genes	352	26
Downstream of kinase family	4	0
Dual specificity phosphatases	23	0
Essential For Cell Division - derived from a siRNA screen in human cells	21	0
Ets transcription factor family	28	0
FK506/rapamycin binding protein family	24	1
Forkhead transcription factor family	36	0
GAP-GEF genes	173	2
Genes associated with ERB family of RTKs	8	1
Genes associated with MYC proteins	20	2
Genes associated with RAS proteins	53	0
Genes associated with TP53 and targets	48	0
Genes found in translocated regions	131	1
Genes from RNAi TSG gene screen	5	0
Genes implicated in stem cell regulation	67	0
Genes in amplified regions, internal CGP data	200	7
Genes on APC/CTNNB1 pathway	61	1
Glycolysis associated genes	23	1
Growth Arrest Specific Genes	7	0
Heat shock proteins	42	2
Heat shock proteins	34	2
Heterotrimeric G-Proteins	34	0
High mobility group proteins - DNA binding	17	1
Histone acetyltransferase	7	0
Human homologues of Mouse Retrovirus Tagged Cancer Genes	190	5
Human homologues of putative target cancer genes from transposon screens in the mouse	39	9
Hypoxia inducible factor pathway	23	0
Immediate early/regulator of G-protein signalling family	25	1
Inositol Polyphosphate Phosphatases	15	0
Integrin alpha family	16	0
Integrin beta family	8	0
Kallikrein protease family	16	1
K homology RNA-binding domain, type I	23	0
Renal kinase	518	27
Lamin protein family	5	0
Matrix metallopeptidase family	21	3
Miscellaneous genes of interest from literature sources	94	45
Mps One Binder kinase activator-like	5	0
Nfkappa signalling family	22	0
Notch signalling proteins	55	2
Nuclear receptors and cofactors	96	7
Nucleocytoplasmic transport components	61	4
PAX transcription factor family	11	0
Phosphatidylinositol metabolism	90	6
Phospholipase C family	13	0
Phospholipase D family	5	0
Protein kinase anchor proteins	32	3
Protein Tyrosine Phosphatases (PTP)	51	6
Ral guanine nucleotide dissociation factors	6	0
SCF and APC cell cycle control complex components	98	1
Serpin/TIMP peptidase inhibitor families	44	2
SerThr Phosphatases (PPP)	69	0
Sirtuin family of proteins, homologs to the yeast Sir2 protein	7	0
SMAD protein family	22	0
Small monomeric GTPases	136	1
Small ubiquitin-like modifier (SUMO) protein family	12	0
Sorting NeXin family	27	1
Splicing factor, arginine/serine-rich (SR) family	10	0
STAT and SOCS gene families	44	0
TCA cycle genes	56	4
TP53 responsive genes	75	4
Tripartite motif-containing protein family	47	1
Ubiquitination pathway genes	62	1
Ubiquitin ligases	70	2
Ubiquitin specific peptidase family	50	4
14_3_3 family of scaffold protein	8	1

webmaster@sanger.ac.uk

Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK Tel:+44 (0)1223 834244

Last Modified Thu Feb 24 14:28:54 2011

Genome Research Limited is a charity registered in England with number 1021457

Help | Contact us | Legal | Cookies policy | Data sharing