Cancer Genome Project

Summary

To complement our pilot matched-pair cell line screen of mixed cancer types through 4000 genes for somatic mutations, we have undertaken a deeper screen of the same genes in a single tumour type - clear cell carcinoma of the kidney. Clear cell cancer accounts for the vast majority of kidney cancers diagnosed. These data are derived from mutation screening of 96 primary tumours.

Somatic mutation data will be released on a bi-monthly basis with verified and annotated somatic mutations accrued in the prior two months being released in each cycle.

For ease of viewing/navigation, genes are organised into categories according to general families and functions.

Click here to download Primer Sequences.

Renal Matched Pair Tumour Set Data

Study	Genes	Mutations
ADAM metallopeptidase family	40	4
Apobec family	8	0
Apoptosis genes	183	5
Arachidonate metabolism and phospholipase A2 family	14	0
Chemokine (C-X-C motif) ligand	9	0
C-X-C/C-C motif chemokine receptor genes	19	0
Cyclins and genes associated with RB	68	2
Cyclooxygenase family	6	0
Cytochrome C oxidase family	23	0
DEAD box proteins	57	4
Diacylglycerol kinases and other lipid kinases	18	2
DNA methylation and histone deacetylation	39	0
DNA repair genes	352	26
Downstream of kinase family	4	0
Dual specificity phosphatases	23	0
Essential For Cell Division - derived from a siRNA screen in human cells	21	0
Ets transcription factor family	28	0
FK506/rapamycin binding protein family	24	1
Forkhead transcription factor family	36	0
GAP-GEF genes	173	2
Genes associated with ERB family of RTKs	8	1
Genes associated with MYC proteins	20	2
Genes associated with RAS proteins	53	0
Genes associated with TP53 and targets	48	0
Genes found in translocated regions	131	1
Genes from RNAi TSG gene screen	5	0
Genes implicated in stem cell regulation	67	0
Genes in amplified regions, internal CGP data	200	7
Genes on APC/CTNNB1 pathway	61	1
Glycolysis associated genes	23	1
Growth Arrest Specific Genes	7	0
Heat shock proteins	42	2
Heat shock proteins	34	2
Heterotrimeric G-Proteins	34	0
High mobility group proteins - DNA binding	17	1
Histone acetyltransferase	7	0
Human homologues of Mouse Retrovirus Tagged Cancer Genes	190	5
Human homologues of putative target cancer genes from transposon screens in the mouse	39	9
Hypoxia inducible factor pathway	23	0
Immediate early/regulator of G-protein signalling family	25	1
Inositol Polyphosphate Phosphatases	15	0
Integrin alpha family	16	0
Integrin beta family	8	0
Kallikrein protease family	16	1
K homology RNA-binding domain, type I	23	0
Renal kinase	518	27
Lamin protein family	5	0
Matrix metallopeptidase family	21	3
Miscellaneous genes of interest from literature sources	94	45
Mps One Binder kinase activator-like	5	0
Nfkappa signalling family	22	0
Notch signalling proteins	55	2
Nuclear receptors and cofactors	96	7
Nucleocytoplasmic transport components	61	4
PAX transcription factor family	11	0
Phosphatidylinositol metabolism	90	6
Phospholipase C family	13	0
Phospholipase D family	5	0
Protein kinase anchor proteins	32	3
Protein Tyrosine Phosphatases (PTP)	51	6
Ral guanine nucleotide dissociation factors	6	0
SCF and APC cell cycle control complex components	98	1
Serpin/TIMP peptidase inhibitor families	44	2
SerThr Phosphatases (PPP)	69	0
Sirtuin family of proteins, homologs to the yeast Sir2 protein	7	0
SMAD protein family	22	0
Small monomeric GTPases	136	1
Small ubiquitin-like modifier (SUMO) protein family	12	0
Sorting NeXin family	27	1
Splicing factor, arginine/serine-rich (SR) family	10	0
STAT and SOCS gene families	44	0
TCA cycle genes	56	4
TP53 responsive genes	75	4
Tripartite motif-containing protein family	47	1
Ubiquitination pathway genes	62	1
Ubiquitin ligases	70	2
Ubiquitin specific peptidase family	50	4
14_3_3 family of scaffold protein	8	1

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Last Modified Thu Feb 24 14:28:58 2011

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