|Identifying Cell Lines With A Common Ancestor|
Over several decades, a number of cell lines have contaminated other cell cultures. The best known example is HeLa which has appeared under many other names. It is possible to identify samples derived from the same individual on the basis of their polymorphic marker genotypes ("DNA fingerprint"). The genotype information for all the cell lines and primary tumour DNAs analysed using the Affymetrix SNP arrays were compared by pair-wise analysis. A plot of the pair-wise comparisons against percentage identity is shown. All comparisons which have an identity greater than 70% are included in the table shown below. These pairs of lines are highly likely to have been derived from the same individual and therefore most are probably derivatives of each other.