Significance of number of proteins with pfam domains within specific cancer sub-classes.

Displayed is the probability of the same or a greater number of proteins with a given domain in a randomly selected set of human proteins of the same size under a binomial distribution. We display only those results which are significant at 5% with a Bonferonni correction. This is Table 4 in Futreal et al.

		Pfam domain		Dominant vs Recessive				Germline vs somatic				Cell type								Translocation vs not translocation
				Dominant		Recessive		Germline		Somatic		Epithelial		Lymphoma		Mesenchymal		Other		Translocation		Not translocation
		pkinase		2.27E-01						6.36E-09		4.39E-08						6.48E-01				1.78E-01
		HLH		3.52E-01						3.52E-01		4.73E-01		1.16E-01						1.83E-07
		homeobox		3.67E-08						3.67E-08				2.76E-07						7.33E-09
		Ets		5.94E-07						5.94E-07						2.88E-01				2.69E-07
		PAX		1.86E-06						1.86E-06						2.67E-01				1.86E-06
		PHD		1.27E-06						1.27E-06				3.44E-06						4.63E-07
		DNA_mis_repair				1.79E-07		9.80E-08				2.46E-07										3.14E-07
		HATPase_c				3.56E-01		3.25E-01				8.36E-01										1.19E-01
		Myc_N_term		8.79E-06						8.79E-06		1.23E-01										6.12E-07
		AF-4		2.38E-01						2.38E-01				1.19E-01						1.59E-01
		bromodomain								4.23E-01		4.12E-01								2.22E-01
		DUF902								1.14E-01				7.15E-01						8.70E-01
		KIX								1.14E-01				7.15E-01						8.70E-01
		SH2		6.89E-01						6.89E-01										2.51E-01
		PWWP
		DUF906								2.55E-01				1.63E-01						1.95E-01
		HRDC				2.14E-01		2.65E-01				3.69E-01		1.63E-01								4.34E-01
		zf-TAZ								2.55E-01				1.63E-01						1.95E-01
		ETS_PEA3_N		2.55E-01						2.55E-01						2.65E-01				1.95E-01
		SAM_PNT								3.23E-01						7.38E-06				2.17E-01
		MutS_I				3.80E-01		3.56E-01				6.55E-01										7.69E-01
		Exostosin				3.80E-01		3.56E-01								3.56E-01						7.69E-01
		SSXT														5.56E-01
		Nucleoporin_FG
		MutS_II				5.92E-01		5.56E-01				1.23E-01										1.20E-01
		SH3		2.89E-01						2.89E-01				2.14E-01						7.53E-01
		GTP_CDC												3.45E-01
		DEAD
		ERM
		YEATS
		HSP90
		MutS_IV				1.16E-01		1.86E-01				2.00E-01										2.34E-01
		AT_hook
		helicase_C				2.53E-01		2.21E-01
		MutS_III				1.51E-01		1.42E-01				2.62E-01										3.52E-01
		Recep_L_domain																				3.52E-01
		Furin-like																				3.52E-01
		zf-RanBP														3.59E-01
		7tm_1
		MOZ_SAS
		Tropomyosin
		MutS_V				2.84E-01		2.67E-01
		ENTH
		Myosin_N
		Armadillo_seg																1.63E-01
		COX6C
		AICARFT_IMPCHas
		Ribosomal_L22e
		Tuberin																1.14E-01
		Fanconia
		APC_15aa																1.14E-01
		GMP_synt_C
		CybS																1.14E-01
		Hamartin																1.14E-01
		EB1_binding																1.14E-01
		XPA_N
		Cdc73
		WT1																1.14E-01
		HNF-1A_C
	VHL																1.14E-01
	Myc-LZ
	UPF0023
	BRCA2
	XPA_C
	Fanconi
	Fork_head
	LIM
	Myosin_tail
	CARD
	Menin
	CBF_beta
	APC_basic
	HNF-1B_C
	Topoisomerase_I
	Topoisomer_I_N
	PDGF_N
	Nucleoplasmin
	SUFU
	MoeA_N
	SNF5
	Fip1
	MoeA_C
	Clathrin_propel
	Sdh_cyt
	Rad4
	zf-MYND
	hormone_rec
	zf-C4
	ZZ
	SAMP
	TCL1_MTCP1
	RB_A
	Caudal_act
	RB_B
	Rabaptin
	Nucleoporin2
	Runt
	MGS
	APC_crr
	BH4
	ERCC4
	YLP
	FHA
	Cbl_N2
	Cbl_N3
	lyase_1
	Cbl_N
	HNF-1_N
	Band_41
	XPG_I
	Hox9_act
	P53
	TIG
	RhoGAP
	death
	FYRN
	MoCF_biosynth
	FYRC
	HhH-GPD
	pKID
	I_LWEQ
	Glypican
	notch
	GATase
	PBX
	TFR_dimer
	BCL_N
	PAS
	zf-B_box
	fer2
	XPG_N
	Patched
	RBD
	FAT
	Clathrin
	ras
	3_5_exonuclease
	DIL
	MH2
	BTK
	Anti_proliferat
	myosin_head
	NAC
	HHH
	FATC
	Peptidase_M28
	WH1
	Nebulin
	UBA
	SET
	IRF
	PDGF
	RIIa
	BIR
	RHD
	Activin_recp
	zf-C3HC4
	cyclin_C
	Frizzled
	OAR
	MH1
	Peptidase_C14
	Rap_GAP
	CAP_GLY
	ig
	RasGAP
	NAP
	GATA
	WD40
	COLFI
	DAG_PE-bind
	zf-CXXC
	BTB
	Bcl-2
	PB1
	UBX
	MAM
	NACHT
	WH2
	PA
	RhoGEF
	FCH
	LRRCT
	NUDIX
	Cadherin_C_term
	TNFR_c6
	PBD
	LRR
	PSI
	PI3_PI4_kinase
	G-alpha
	BRCT
	Fz
	SAP
	IQ
	cyclin
	cNMP_binding
	AMP-binding
	rrm
	kazal
	Sema
	zf-C2H2
	RA
	pkinase_C
	EGF
	histone
	bZIP
	LRRNT
	Y_phosphatase
	cadherin
	ank
	HMG_box
	WW
	UCH
	CH
	PDZ
	PH
	C2
	Collagen
	efhand
	KRAB
	All proteins