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Cancer Gene Census

Cancer genes that have deletion mutations.

This table is a list of the cancer genes that are characterised by large deletions and covers the abnormalities that result in allele loss/loss of heterozygosity at many recessive cancer genes. The full version of this table can be downloaded here .This is part of Table 1 in Futreal et al.


Symbol Name Entrez GeneID Tumour Types (Somatic Mutations) Tumour Types (Germline Mutations) Cancer Syndrome
APC adenomatous polyposis of the colon gene 324 colorectal, pancreatic, desmoid, hepatoblastoma, glioma, other CNS colorectal, pancreatic, desmoid, hepatoblastoma, glioma, other CNS Adenomatous polyposis coli; Turcot syndrome
ATM ataxia telangiectasia mutated 472 T-PLL leukemia, lymphoma, medulloblastoma, glioma Ataxia-telangiectasia
BRCA1 familial breast/ovarian cancer gene 1 672 ovarian breast, ovarian Hereditary breast/ovarian cancer
BRCA2 familial breast/ovarian cancer gene 2 675 breast, ovarian, pancreatic breast, ovarian, pancreatic, leukemia (FANCB, FANCD1) Hereditary breast/ovarian cancer
CDKN2A- p14ARF cyclin-dependent kinase inhibitor 2A-- p14ARF protein 1029 melanoma, multiple other tumour types melanoma, pancreatic Familial malignant melanoma
CDKN2A -p16(INK4a) cyclin-dependent kinase inhibitor 2A (p16(INK4a)) gene 1029 melanoma, multiple other tumour types melanoma, pancreatic Familial malignant melanoma
FANCA Fanconi anemia, complementation group A 2175 AML, leukemia Fanconi anaemia A
FANCC Fanconi anemia, complementation group C 2176 AML, leukemia Fanconi anaemia C
FANCD2 Fanconi anemia, complementation group D2 2177 AML, leukemia Fanconi anaemia D2
FBXW7 F-box and WD-40 domain protein 7 (archipelago homolog, Drosophila) 55294 colorectal, endometrial, T-ALL
GPC3 glypican 3 2719 Wilms tumour Simpson-Golabi-Behmel syndrome
KDM6A lysine (K)-specific demethylase 6A, UTX 7403 renal, oesophageal SCC, MM
MADH4 Homolog of Drosophila Mothers Against Decapentaplegic 4 gene 4089 colorectal, pancreatic, small intestine gastrointestinal polyps Juvenile polyposis
MAP2K4 mitogen-activated protein kinase kinase 4 6416 pancreatic, breast, colorectal
MEN1 multiple endocrine neoplasia type 1 gene 4221 parathyroid tumors parathyroid adenoma, pituitary adenoma, pancreatic islet cell, carcinoid Multiple Endocrine Neoplasia Type 1
MLH1 E.coli MutL homolog gene 4292 colorectal, endometrial, ovarian, CNS colorectal, endometrial, ovarian, CNS Hereditary non-polyposis colorectal cancer, Turcot syndrome
MSH2 mutS homolog 2 (E. coli) 4436 colorectal, endometrial, ovarian colorectal, endometrial, ovarian Hereditary non-polyposis colorectal cancer
NF1 neurofibromatosis type 1 gene 4763 neurofibroma, glioma neurofibroma, glioma Neurofibromatosis type 1
NF2 neurofibromatosis type 2 gene 4771 meningioma, acoustic neuroma, renal, mesothelioma meningioma, acoustic neuroma Neurofibromatosis type 2
PTEN phosphatase and tensin homolog gene 5728 glioma, prostate, endometrial harmartoma, glioma, prostate, endometrial Cowden Syndrome, Bannayan-Riley-Ruvalcaba syndrome
RB1 retinoblastoma gene 5925 retinoblastoma, sarcoma, breast, small cell lung retinoblastoma, sarcoma, breast, small cell lung Familial retinoblastoma
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 6598 malignant rhabdoid malignant rhabdoid Rhabdoid predisposition syndrome
STK11 serine/threonine kinase 11 gene (LKB1) 6794 NSCLC, pancreatic jejunal harmartoma, ovarian, testicular, pancreatic Peutz-Jeghers syndrome
SUFU suppressor of fused homolog (Drosophila) 51684 medulloblastoma medulloblastoma Medulloblastoma predisposition
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 7128 marginal zone B-cell lymphomas, Hodgkin's lymphoma, primary mediastinal B cell lymphoma
TSC1 tuberous sclerosis 1 gene 7248 hamartoma, renal cell Tuberous sclerosis 1
TSC2 tuberous sclerosis 2 gene 7249 hamartoma, renal cell Tuberous sclerosis 2
VHL von Hippel-Lindau syndrome gene 7428 renal, hemangioma, pheochromocytoma renal, hemangioma, pheochromocytoma von Hippel-Lindau syndrome
WT1 Wilms tumour 1 gene 7490 Wilms, desmoplastic small round cell tumor Wilms Denys-Drash syndrome, Frasier syndrome, Familial Wilms tumor
WTX family with sequence similarity 123B (FAM123B) 139285 Wilms tumour

A, amplification; AEL, acute eosinophilic leukemia; AL, acute leukemia; ALCL, anaplastic large-cell lymphoma; ALL, acute lymphocytic leukemia; AML, acute myelogenous leukemia; AML*, acute myelogenous leukemia (primarily treatment associated); APL, acute promyelocytic leukemia; B-ALL, B-cell acute lymphocytic leukaemia; B-CLL, B-cell Lymphocytic leukemia; B-NHL, B-cell Non-Hodgkin Lymphoma; CLL, chronic lymphatic leukemia; CML, chronic myeloid leukemia; CMML, chronic myelomonocytic leukemia; CNS, central nervous system; D, large deletion; DFSP, dermatofibrosarcoma protuberans; DLBL, diffuse large B-cell lymphoma; DLCL, diffuse large-cell lymphoma; Dom, dominant; E, epithelial; F, frameshift; GIST, gastrointestinal stromal tumour; JMML, juvenile myelomonocytic leukemia; L, leukaemia/lymphoma; M, mesenchymal; MALT, mucosa-associated lymphoid tissue lymphoma; MDS, myelodysplastic syndrome; Mis, Missense; MLCLS, mediastinal large cell lymphoma with sclerosis; MM, multiple myeloma; MPD, Myeloproliferative disorder; N, nonsense; NHL, non-Hodgkin lymphoma; NK/T, natural killer T cell; NSCLC, non small cell lung cancer; O, other; PMBL, primary mediastinal B-cell lymphoma; pre-B All, pre-B-cell acute lymphoblastic leukaemia; Rec, recesive; S, splice site; T, translocation; T-ALL, T-cell acute lymphoblastic leukemia; T-CLL, T-cell chronic lymphocytic leukaemia; TGCT, testicular germ cell tumour; T-PLL, T cell prolymphocytic leukaemia;


 
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Last Modified Wed Feb 28 16:43:09 2007

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