For decades, human immortal cancer cell lines have constituted an accessible, easily usable set of biological models with which to investigate cancer biology and to explore the potential efficacy of anticancer drugs. In order to improve their utility the Cancer Genome Project has embarked on a systematic characterisation of the genetics and genomics of large numbers of cancer cell lines. Prior knowledge of their genetic abnormalities may allow more informed choice of cancer cell lines in biological experiments and drug testing and more informed interpretation of results. [more].

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1. Copy Number analysis

Genome-wide loss of heterozygosity and copy number analyses using SNP arrays.

2. Microsatellite instability

Detection of microsatellite instability due to DNA mismatch repair defects.

3. Cell line identity typing

A SNP and STR fingerprint for each cell line is available. Where possible the identity has been confirmed using the STR profile.

4. Additional variants

Additional variants classified as Tenatively Oncogenic Variant (TOV) and Unknown Variant (UV) are available to download as an Excel spreadsheet

Our target is to sequence all known cancer genes in all of the cell lines. However, we release data before we achieve this goal. Therefore the present results should be considered as work in progress. This resource will be updated in the future. The present somatic mutation count is: