The Wellcome Trust Sanger Institute Pathogen Sequencing Unit (PSU) is partially shotgun sequencing the nuclear genome of the human-infective Trypanosoma brucei gambiense. While the non-human-infective T. b. brucei is the preferred model organism for studying trypanosome biology, comparison with a human-infective organism is required to study mechanisms of disease. Human trypanosomiasis is caused by 2 other subspecies of T. brucei - T. b. rhodesiense and T. b. gambiense. T. b. rhodesiense is very similar to T. b. brucei, and so the genome sequence of T. b. brucei will provide information on both subspecies. However, T. b. gambiense stands apart, with profoundly different biological and genetic characteristisc (click here to see more details). The T. b. gambiense genome will serve as a useful comparative genomics resource to complement the genomes of Trypanosoma vivax, Trypanosoma congolense and Trypanosoma brucei, which has been sequenced in collaboration between the PSU and The Institute for Genomic Research. The T. b. gambiense partial shotgun project is being carried out in collaboration with Wendy Gibson (University of Bristol, UK).
- Information
Sequencing strategy
- Access to Sequence Data
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- Data release policy
- ftp and overview for downloading of sequence
- Sequence similarity searches
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- Overview of available data
- omniBLAST server
- BLAST server
