The Sanger Institute has completed the sequencing of and recently published the 1.84 Mb genome of Streptococcus pyogenes strain Manfredo (M5), in collaboration with Prof. Mike Kehoe, of the School of Cell and Molecular Biosciences, University of Newcastle.
Streptococcus pyogenes (Group A Strep) strains are associated with a wide variety of clinical manifestations, including streptococcal toxic-shock syndrome, acute rheumatic fever, scarlet fever, and others. The strain chosen for this project is associated with acute rheumatic fever, and was isolated from a patient in Chicago in the late 1950's.
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The complete ManfredoThe databases are available for searching on our BLAST server, and for download from our FTP site
The annotation for the S. pyogenes Manfredo genome is now accessible through GeneDB. GeneDB allows searching, browsing and download of the full annotation.
Both the sequence and annotation have been deposited in the public databases with the accession number AM295007.
Reference:
- "The complete genome of an acute rheumatic fever (ARF) associated serotype M5 Streptococcus pyogenes strain Manfredo" (2007) Journal of Bacteriology 189:1473-1477.
- Matthew T.G. Holden, Annabel Scott, Inna Cherevach, Tracey Chillingworth, Carol Churcher, Ann Cronin, Linda Dowd, Theresa Feltwell, Nancy Hamlin, Simon Holroyd, Kay Jagels, Sharon Moule, Karen Mungall, Michael A. Quail, Claire Price, Ester Rabbinowitsch, Sarah Sharp, Jason Skelton, Sally Whitehead, Bart G. Barrell, Michael Kehoe and Julian Parkhill.
Other sites that may be of interest:
S. pyogenes strain SF370 (M1) sequencing project at the The University of Oklahoma's Advanced Center for Genome Technology.
S. pyogenes strain SSI-1 (M3) sequencing project at the Genome Information Research Center, Osaka University.
