| Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2). Bentley SD, Chater KF, Cerdeño-Tárraga AM, Challis GL, Thomson NR, James KD, Harris DE, Quail MA, Kieser H, Harper D, Bateman A, Brown S, Chandra G, Chen CW, Collins M, Cronin A, Fraser A, Goble A, Hidalgo J, Hornsby T, Howarth S, Huang CH, Kieser T, Larke L, Murphy L, Oliver K, O'Neil S, Rabbinowitsch E, Rajandream MA, Rutherford K, Rutter S, Seeger K, Saunders D, Sharp S, Squares R, Squares S, Taylor K, Warren T, Wietzorrek A, Woodward J, Barrell BG, Parkhill J, Hopwood DA Nature. 2002;417;141-7. PMID: 12000953 |
The Sanger Institute has completed the sequencing of the Streptomyces coelicolor A3(2) genome in collaboration with Prof. David Hopwood of the John Innes Centre.
The chromosome is 8,667,507bp long with a G+C content of 72.1% and is predicted to contain 7825 protein encoding genes.
Streptomyces coelicolor A3(2) is the model representative of a group of soil-dwelling organism with a complex lifecycle involving mycelial growth and spore formation. These microbes are notable for their production of pharmaceutically useful compound including anti-tumour agents, immunosupressants and over two-thirds of all natural antibiotics currently available. The sequence was generated using a clone-by-clone approach, initially using cosmids generated and mapped by David Hopwood's group at the John Innes Centre, and latterly using a BAC library to fill gaps and confirm the map.
This project is funded by the BBSRC and Beowulf Genomics.
