The Sanger Institute is involved in sequencing projects for both of the major human malarial parasites Plasmodium vivax and Plasmodium falciparum. P. vivax causes severe disease in humans but unlike P. falciparum it is rarely fatal. This project is part of a study to compare the genomes of the two organisms in an attempt to understand differences in their pathology. The Sanger Institute has is sequencing a single P. vivax YAC mapping to a telomere, in collaboration with Hernando A. del Portillo at the at the Universidade de Sao Paulo and Michael Lanzer of the Universitat Heidelberg.

The Plasmodium vivax YAC Sequence data

The complete IVD10 YAC clone 155,711 bp in length has now been sequenced, finished and annotated. 32 predicted genes and four pseudogenes have been identified, the majority being members of a novel gene family encoding putative transmembrane proteins. For more information about the structure of the IVD10 clone see the sequence data page. For more about how the sequencing was done see the project information page. Access to the complete finished sequence is available. See our data release policy for more details.

Searching the Plasmodium vivax YAC Sequence data online

A BLAST server now exists to allow easy searching of the Plasmodium vivax YAC sequence. The sequences can also be downloaded from our FTP site. A list of predicted genes and pseudogenes is also available here with links to the predicted protein product sequences and annotation.