Mycobacterium tuberculosis
Electron micrograph of M. tuberculosis courtesy of the Institut Pasteur image library
The recently re-annotated genome of Mycobacterium tuberculosis has been published in Microbiology:
| Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv. Camus JC, Pryor MJ, Médigue C, Cole ST Microbiology. 2002;148;2967-73. PMID: 12368430 |
The original Mycobacterium tuberculosis genome publication was:
| Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Cole ST, Brosch R, Parkhill J, Garnier T, Churcher C, Harris D, Gordon SV, Eiglmeier K, Gas S, Barry CE, Tekaia F, Badcock K, Basham D, Brown D, Chillingworth T, Connor R, Davies R, Devlin K, Feltwell T, Gentles S, Hamlin N, Holroyd S, Hornsby T, Jagels K, Krogh A, McLean J, Moule S, Murphy L, Oliver K, Osborne J, Quail MA, Rajandream MA, Rogers J, Rutter S, Seeger K, Skelton J, Squares R, Squares S, Sulston JE, Taylor K, Whitehead S, Barrell BG Nature. 1998;393;537-44. PMID: 9634230 DOI: 10.1038/31159 |
The updated genome sequence has been re-submitted to the public databases but is also available here. You can also view the updated annotation of M. tuberculosis genome sequence using TubercuList at the Institut Pasteur, Paris.
You can also search the latest sequence and annotated protein products using our M. tuberculosis Blast server.
The Sanger Institute sequenced M. tuberculosis using cosmids and BAC clones supplied by Dr. Stewart Cole and his colleagues at the Institut Pasteur Unite de Genetique Moleculaire Bacterienne. See references:
| An integrated map of the genome of the tubercle bacillus, Mycobacterium tuberculosis H37Rv, and comparison with Mycobacterium leprae. Philipp WJ, Poulet S, Eiglmeier K, Pascopella L, Balasubramanian V, Heym B, Bergh S, Bloom BR, Jacobs WR, Cole ST Proc Natl Acad Sci U S A. 1996;93;3132-7. PMID: 8610181 |
| Use of a Mycobacterium tuberculosis H37Rv bacterial artificial chromosome library for genome mapping, sequencing, and comparative genomics. Brosch R, Gordon SV, Billault A, Garnier T, Eiglmeier K, Soravito C, Barrell BG, Cole ST Infect Immun. 1998;66;2221-9. PMID: 9573111 |
