Introduction
The Sanger Institute and the Genome Sequencing Center at the Washington University School of Medicine, St. Louis have collaborated to sequence the genomes of both C. elegans and C. briggsae. An essentially complete C. elegans sequence was published in Science in December 1998 (additional notes here including the full list of authors) and the last remaining gap in the sequence was finished in October 2002. A C. briggsae whole-genome shotgun assembly was made available in July 2002 (more information available here).
Accessing Caenorhabditis sequence data
The completed C. elegans genome sequence is represented by over 3,000 individual clone sequences which can be accessed through this site (or through WormBase). These sequences are submitted to EMBL whenever the sequence or annotation changes (e.g. modification to gene structures) and these submissions are then mirrored to GenBank and DDBJ. These sequences (along with ESTs and proteins) can be searched on our C. elegans BLAST server.
For more information on the C. briggsae assembly please see the C. briggsae project page. The assembly sequences can be searched using our C. briggsae BLAST server.
WormBase - the C. elegans genome database
WormBase is the repository of mapping, sequencing and phenotypic information for C. elegans (and some other nematodes). The worm informatics group at the Sanger Institute play a key role in assembling the whole database (a new release occurs every three weeks, more details...). We also curate and develop some of the constituent databases that comprise WormBase.
| Type in a relevant keyword, author, gene or sequence name, etc. |
WormBase is based on the Acedb database system. If you obtain a suitable acedb binary for your system then you can download the latest release of WormBase in acedb format from our local FTP site and run it locally (acedb documenation is available).
WormBase welcomes submission of new data and corrections to existing data. You can submit new data pertaining to new loci, polymorphisms, map positions, alleles etc.
C. elegans links:
- WormBook - The Online Review of C.elegans Biology. Or try the Sanger hosted mirror
- Oligo design tool at C. elegans Knockout Consortium site
- Repeat sequences characterised from the C.elegans genome.
- Information on the current data analysis procedure
- Vector sequences used in the C. elegans sequencing project as well as other vector sequences used in genomic sequencing
- Vector designations for the C. elegans physical map
- Tc1 insertion polymorphisms: Information on transposon Tc1 derived sequence tagged sites
- Resources: for Genefinding in C. elegans
- Genefinder:A quick users guide and tutorial
- Caenorhabditis elegans WWW Server: Resources for the C. elegans community
- Yuji Kohara's C. elegans EST pages
- Polyadenylation signal and cleavage site predictions
