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| Circular representation of the Corynebacterium diphtheriae NCTC13129 genome. Click on image to see a larger picture |
The Sanger Institute has completed the sequence and analysis of Corynebacterium diphtheriae strain NCTC13129, in collaboration with Dr. Androulla Efstratiou, of the W.H.O. collaborating centre for diphtheria, Respiratory and Systemic Infection Laboratory, at the Health Protection Agency, U.K.
Corynebacterium diphtheriae is the causative agent of diphtheria, and biotype gravis strain NCTC13129 is a recent U.K. clinical isolate representative of an epidemic clone now circulating within the Eastern European region.
**6th November 2003: Publication of this project: Cerdeño-Tárraga et al. (2003). The complete genome sequence and analysis of Corynebacterium diphtheriae NCTC13129, Nucleic Acids Research 31(22):6516-6523.
The genome is 2,488,635 bp long and contains 2320 CDS, with an average G+C content of 53.5%. It was assembled from 66,099 sequencing reads.
The sequencing data is available for download by FTP and can be searched using our BLAST server.
The annotation for the C. diphtheriae genome is now accessible through
GeneDB. GeneDB allows searching, browsing and download of the full annotation.
The project has been submitted to the EMBL/GenBank database with accession number BX248353 and the sequence and annotation files are also available to download in Artemis format.
Other sites that may be of interest:
Information on diphtheria from the W.H.O.
Information on immunisation from the NHS (UK)
Facts about diphtheria from the National Foundation for Infectious Diseases (US)
Information on the microorganism Dept. of Bacteriology. University of Wisconsin-Madison (US)
