Malaria Cell Atlas
The Malaria Cell Atlas aims to provide a resource of single cell transcriptomic data across the full lifecycle of the parasite.
Nearly half of the world’s population remains at risk for malaria with 216 million reported cases in 2016 and over 400,000 deaths. Understanding transcriptional diversity across the lifecycle under different disease settings will help in the fight to eliminate and eventually eradicate this disease.
As of August 2019, the Malaria Cell Atlas includes data from our eLife and Biorxiv papers, which describe methods we have used and optimised to generate single cell transcriptomes for malaria parasites. Our Atlas includes single cell RNA-sequencing data covering all stages of the life cycle in both Anopheles vector and mammalian host tissues, spans both cell sorting and droplet-based scRNAseq and includes four Plasmodium species, including three human pathogens. It also includes the first single cell data from parasites isolated directly from clinical samples.
VISUALISE DATA <- explore how genes are expressed over thousands of individual Plasmodium parasites from across the life cycle.
DOWNLOAD DATA <- Our Github contains gene count tables for all scRNAseq data.
eLife RAW DATA <- European Nucleotide Archive accession ERP021229
Biorxiv RAW DATA <- European Nucleotide Archive accession ERP110344
eLife paper <- Further information about this study.
Biorxiv paper <- Further information about this study.
The Malaria Cell Atlas is supported by Wellcome (WT098051) and by a Medical Research Council Career Development Award (G1100339) to Mara Lawniczak. The authors would like to thank the staff of the Illumina Bespoke Sequencing and Core Cytometry teams at the Wellcome Sanger Institute for their contribution.
Sanger Institute Contributors
The Parasite Genomics group uses comparative and functional genomics approaches to investigate the biology of helminths and protozoan parasites.
Programmes and Facilities
We are focused on using single-cell approaches, so called “cell atlas” technologies and understanding human genetics at the cellular level. The ...
Human Cell Atlas
The International Human Cell Atlas initiative aims to create comprehensive reference maps of all human cells—the fundamental units of life— ...