Proteome Characterisation and Quantification

Proteome Characterisation and Quantification

Proteome Characterisation and Quantification


We are constantly developing novel mass spectrometry and informatics techniques to improve protein identification and quantification. These include profiling the changes in protein expression in diseased organisms, analysis of protein localisation to subcellular organelles, studies examining protein synthesis and turn-over and absolute quantification of protein species.


  • A Plasmodium calcium-dependent protein kinase controls zygote development and transmission by translationally activating repressed mRNAs.

    Sebastian S, Brochet M, Collins MO, Schwach F, Jones ML et al.

    Cell host & microbe 2012;12;1;9-19

  • Quantitative RNA-seq analysis of the Campylobacter jejuni transcriptome.

    Chaudhuri RR, Yu L, Kanji A, Perkins TT, Gardner PP et al.

    Microbiology (Reading, England) 2011;157;Pt 10;2922-32

  • Characterization of the proteome, diseases and evolution of the human postsynaptic density.

    Bayés A, van de Lagemaat LN, Collins MO, Croning MD, Whittle IR et al.

    Nature neuroscience 2011;14;1;19-21

  • Evolutionary expansion and anatomical specialization of synapse proteome complexity.

    Emes RD, Pocklington AJ, Anderson CN, Bayes A, Collins MO et al.

    Nature neuroscience 2008;11;7;799-806