We develop novel genome editing techniques, cellular differentiation and cellular phenotyping systems, especially with respect to high-throughput investigation of gene and non-coding regulatory element function.
- Developing induced pluripotent stem cell models of genetic disease
- Genetic screening techniques using pooled and arrayed CRISPR/Cas9
- Differentiation protocols of pluripotent stem cells to brain and blood-derived lineages
- Application of screening to complex phenotypic readouts such as single cell transcriptomics or spatial genomics