Gene Editing and Cellular Research and Development | Cellular Operations

Gene Editing and Cellular Research and Development | Cellular Operations

Gene Editing and Cellular Research and Development

Group Photo

Our Research and Approach

We develop novel genome editing techniques, cellular differentiation and cellular phenotyping systems, especially with respect to high-throughput investigation of gene and non-coding regulatory element function. 

  • Developing induced pluripotent stem cell models of genetic disease
  • Genetic screening techniques using pooled and arrayed CRISPR/Cas9
  • Differentiation protocols of pluripotent stem cells to brain and blood-derived lineages
  • Application of screening to complex phenotypic readouts such as single cell transcriptomics or spatial genomics 
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Bassett, Andrew
Dr Andrew Bassett
Group Leader
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Key Projects, Collaborations, Tools & Data

Partners and Funders

Internal Partners
External Partners and Funders


  • Editing the Genome of Human Induced Pluripotent Stem Cells Using CRISPR/Cas9 Ribonucleoprotein Complexes.

    Bruntraeger M, Byrne M, Long K and Bassett AR

    Methods in molecular biology (Clifton, N.J.) 2019;1961;153-183

  • Predicting the mutations generated by repair of Cas9-induced double-strand breaks.

    Allen F, Crepaldi L, Alsinet C, Strong AJ, Kleshchevnikov V et al.

    Nature biotechnology 2018

  • In situ functional dissection of RNA cis-regulatory elements by multiplex CRISPR-Cas9 genome engineering.

    Wu Q, Ferry QRV, Baeumler TA, Michaels YS, Vitsios DM et al.

    Nature communications 2017;8;1;2109

  • Alpha-synuclein induces the unfolded protein response in Parkinson's disease SNCA triplication iPSC-derived neurons.

    Heman-Ackah SM, Manzano R, Hoozemans JJM, Scheper W, Flynn R et al.

    Human molecular genetics 2017;26;22;4441-4450

  • Editing the genome of hiPSC with CRISPR/Cas9: disease models.

    Bassett AR

    Mammalian genome : official journal of the International Mammalian Genome Society 2017;28;7-8;348-364

  • Precision Modulation of Neurodegenerative Disease-Related Gene Expression in Human iPSC-Derived Neurons.

    Heman-Ackah SM, Bassett AR and Wood MJ

    Scientific reports 2016;6;28420

  • A genome-wide CRISPR library for high-throughput genetic screening in Drosophila cells.

    Bassett AR, Kong L and Liu JL

    Journal of genetics and genomics = Yi chuan xue bao 2015;42;6;301-9

  • Understanding functional miRNA-target interactions in vivo by site-specific genome engineering.

    Bassett AR, Azzam G, Wheatley L, Tibbit C, Rajakumar T et al.

    Nature communications 2014;5;4640

  • Mutagenesis and homologous recombination in Drosophila cell lines using CRISPR/Cas9.

    Bassett AR, Tibbit C, Ponting CP and Liu JL

    Biology open 2014;3;1;42-9

  • Highly efficient targeted mutagenesis of Drosophila with the CRISPR/Cas9 system.

    Bassett AR, Tibbit C, Ponting CP and Liu JL

    Cell reports 2013;4;1;220-8