The Sanger Institute Research Support Facility (RSF) serves the Institute and worldwide community by providing and caring for mice used in research studies. In conjunction with the RSF the Mouse Pipelines teams support biomedical research through the humane and optimized use of genetically-modified mice. Under the most stringent care for the welfare of the animals, the mouse pipelines team generates, phenotypes, cryopreserves, and distributes new mouse strains to galvanize biomedical research.
The work of the Research Support Facility and Mouse Pipelines teams are underpinned by our Mouse Colony Management System (MCMS). This system was developed in-house by the Scientific Operations Mouse Informatics Team and enables us to demonstrate, at the highest standards, our high levels of efficient production, colony management and archiving. The database is continually improved by the Mouse Informatics Team in conjunction with the Mouse Pipelines and Research Support Facility teams.
The Mouse Phenotyping team delivers phenotypic characterisation of mutant mice, typically knockouts of protein coding genes. Phenotyping encompasses a standardised set of more than 600 clinical parameters, and covers key biomedical areas such as reproduction, development, infection and immunity, musculoskeletal system, metabolism and endocrinology.