The DNA Sequencing area teams of the Wellcome Sanger Institute support the research of all scientists in their use of genomic data to understand the underlying biology of health, disease and evolution. From cancer to the individual cells that make up a human body, and from parasitic worms to endangered species, our DNA sequencing teams employ specialist knowledge to apply a range of DNA reading technologies (from so-called shotgun sequencing using next-generation sequencers and reference genomes, to single-molecule real-time long-read approaches that can provide high-quality de novo reference genomes).
The DNA Sequencing area teams of the Wellcome Sanger Institute support the research of all scientists in their use of genomic data to understand the underlying biology of health, disease and evolution. From cancer to the individual cells that make up a human body, and from parasitic worms to endangered species, our DNA sequencing teams employ specialist knowledge to apply a range of DNA reading technologies. Ian Johnston, Head of Sequencing Operations, leads the DNA sequencing teams.
The DNA Sequencing teams deliver:
High quality human genomes on the latest Illumina sequencing platforms at significant scale
In-depth long read sequences of both human and animal genomes on PacBio and ONT platforms
Continuous improvement and refinement of protocols to maximise the efficiency of products and pipelines
High quality customer service provision to our stakeholders through our dedicated scientific support team
The equivalent of one 30X human genome every 3.5 minutes
The equivalent of one 1X human genome every 7 seconds
The DNA sequence for around 63 different species per month
In collaboration DNA sequencing teams are processing the remaining 450,000 samples in the UK Biobank cohort. UKB is a major national resource for health research, with the aim of improving the prevention, diagnosis and treatment of a wide range of serious and life-threatening illnesses – including cancer, heart diseases, stroke, diabetes, arthritis, osteoporosis, eye disorders, depression and forms of dementia.
Our DNA Sequencing area teams support the folllowing key activities of the Sanger Institute
We are surveying the genomes of the parasitic worms that have the greatest impact on human, agricultural and veterinary disease and cause significant global health issues, particularly in the developing world.
The aim of the Deciphering Developmental Disorders (DDD) Study is to advance clinical genetic practice for children with developmental disorders by the systematic application of the latest microarray and sequencing methods while addressing the new ethical challenges raised.
A consortium funded by a Wellcome Trust Strategic Award to develop game-changing research tools for the study and manipulation of parasitic flatworm species responsible for the devastating diseases echinococcosis (hydatid disease) and schistosomiasis (bilharzia).
The International Human Cell Atlas initiative aims to create comprehensive reference maps of all human cells—the fundamental units of life—as a basis for both understanding human health and diagnosing, monitoring, and treating disease.
This CRUK-funded Grand Challenge Project (Mutographs.org) seeks to fill in the missing gaps to identify the unknown cancer-causing factors and reveal how they lead to cancer. To do this 5,000 pancreatic, kidney, oesophageal and bowel cancer patients, from five continents will be studied and compared.
The DNA Pipelines Research and Development group is the entry point for new technologies to the Institute, especially sequencing instruments. The team develops new methods and procedures to maximise the efficiency, quality and throughput of all incoming machinery for the benefit all Institute researchers.