Olfactory Transcriptomes of Mice

Olfactory Transcriptomes of Mice

Olfactory Transcriptomes of Mice

Overview

The olfactory (OR) and vomeronasal receptor (VR) repertoires are collectively encoded by 1700 genes and pseudogenes in the mouse genome. The are among the largest gene families in mammals. Yet most only have coding sequences annotated in existing databases, and many lack experimental support due to the similarity between them and their unusual monogenic, sensory cell-specific expression in olfactory tissues.

The aim of the olfactory transcriptomes project was to catalogue the genes expressed in the two major olfactory tissues of C57BL/6J mice, the olfactory mucosa (OM) and vomeronasal organs (VNO). Then to use these data to generate new, extended gene annotations for the OR and VR gene repertoires.

The raw sequence data are available from the European Nucleotide Archive (ENA) under accessions PRJEB2572 and PRJEB1365, and can be reused without restriction.

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References

  • The olfactory transcriptomes of mice.

    Ibarra-Soria X, Levitin MO, Saraiva LR and Logan DW

    PLoS genetics 2014;10;9;e1004593

  • Molecular and neuronal homology between the olfactory systems of zebrafish and mouse.

    Saraiva LR, Ahuja G, Ivandic I, Syed AS, Marioni JC et al.

    Scientific reports 2015;5;11487

  • Cyclic Regulation of Sensory Perception by a Female Hormone Alters Behavior.

    Dey S, Chamero P, Pru JK, Chien MS, Ibarra-Soria X et al.

    Cell 2015;161;6;1334-44

  • Pregnancy and estrogen enhance neural progenitor-cell proliferation in the vomeronasal sensory epithelium.

    Oboti L, Ibarra-Soria X, Pérez-Gómez A, Schmid A, Pyrski M et al.

    BMC biology 2015;13;104

  • Hierarchical deconstruction of mouse olfactory sensory neurons: from whole mucosa to single-cell RNA-seq.

    Saraiva LR, Ibarra-Soria X, Khan M, Omura M, Scialdone A et al.

    Scientific reports 2015;5;18178