GWAS

(GWAS data used on the Zebrafish Mutation Project Web site comes from http://www.genome.gov/gwastudies/.)

Type 2 diabetes

The human homologues of the following genes have been identified in "Type 2 diabetes" studies:

Gene name Reported Gene Ensembl ID Alleles found Associated phenotype Study Count
ache ACHE ENSDARG00000031796 2 Not determined 2
adamts9 ADAMTS9 ENSDARG00000077778 9 Not determined 5
ap3s2 AP3S2 ENSDARG00000039882 None Not determined 1
apob APOB ENSDARG00000042780 9 Not determined 17
apobl APOB ENSDARG00000022767 11 Not determined 17
arf5 ARF5 ENSDARG00000070472 1 Not determined 1
atg16l1 ATG16L1 ENSDARG00000057430 None Not determined 8
B0R0Z9_DANRE ZPLD1 ENSDARG00000063372 None Not determined 2
B0R100_DANRE ZPLD1 ENSDARG00000079119 None Not determined 2
barx2 BARX2 ENSDARG00000041098 3 Not determined 2
bcl11a BCL11A ENSDARG00000061352 3 Normal 10
BSN (2 of 2) BSN ENSDARG00000079822 23 Not determined 4
BSN (1 of 2) BSN ENSDARG00000079161 11 Not determined 4
C7U131_DANRE PTPRD ENSDARG00000044635 3 Not determined 11
camk1d CAMK1D ENSDARG00000017446 2 Not determined 4
cdc123 CDC123 ENSDARG00000075025 1 Not determined 5
cdkal1 CDKAL1 ENSDARG00000022122 2 Not determined 23
cdkn2b CDKN2A ENSDARG00000037262 2 Not determined 25
cdkn2b CDKN2B ENSDARG00000037262 2 Not determined 30
cetp CETP ENSDARG00000030872 2 Not determined 27
chrm3a CHRM3 ENSDARG00000071091 1 Not determined 4
dctn5 DCTN5 ENSDARG00000003573 None Not determined 1
dusp7 DUSP9 ENSDARG00000032738 None Not determined 2
erbb3a ERBB3 ENSDARG00000006202 1 Not determined 8
erbb3b ERBB3 ENSDARG00000036993 7 Not determined 8
f3a F3 ENSDARG00000021013 None Not determined 3
f3b F3 ENSDARG00000005673 None Not determined 3
fam58a FAM58A ENSDARG00000037537 3 Not determined 1
fitm2 FITM2 ENSDARG00000034568 2 Not determined 1
fto FTO ENSDARG00000044216 3 Not determined 32
galntl4a GALNTL4 ENSDARG00000030292 2 Not determined 1
gcc1 GCC1 ENSDARG00000045541 1 Not determined 1
glis3 GLIS3 ENSDARG00000069726 5 Not determined 6
GRB14 GRB14 ENSDARG00000068280 1 Not determined 5
hmg20a HMG20A ENSDARG00000031198 None Not determined 3
hmga2 HMGA2 ENSDARG00000069912 None Not determined 18
hnf1a HNF1A ENSDARG00000009470 None Not determined 21
hnf1ba HNF1B ENSDARG00000006615 1 Not determined 8
hnf1bb HNF1B ENSDARG00000022295 None Not determined 8
hnf4a HNF4A ENSDARG00000021494 1 Not determined 8
ide IDE ENSDARG00000075570 4 Not determined 2
igf2bp2a IGF2BP2 ENSDARG00000003421 1 Not determined 12
igf2bp2b IGF2BP2 ENSDARG00000061661 2 Not determined 12
im:7150991 WFS1 ENSDARG00000074617 5 Not determined 2
im:7165241 ITGB6 ENSDARG00000002494 1 Not determined 2
irgf1 IRGM ENSDARG00000070774 3 Not determined 5
irgf2 IRGM ENSDARG00000092249 1 Not determined 5
irgf3 IRGM ENSDARG00000062820 None Not determined 5
irgq2 IRGM ENSDARG00000068657 None Not determined 5
jazf1a JAZF1 ENSDARG00000036243 1 Not determined 8
jazf1b JAZF1 ENSDARG00000056793 None Not determined 8
kcnj11 KCNJ11 ENSDARG00000051880 None Not determined 5
kcnj11l KCNJ11 ENSDARG00000031438 None Not determined 5
kcnq1 KCNQ1 ENSDARG00000059798 4 Not determined 15
KCNQ1 KCNQ1 ENSDARG00000091599 None Not determined 15
LAMA1 LAMA1 ENSDARG00000056043 7 Not determined 2
lipin2 LPIN2 ENSDARG00000061214 2 Not determined 1
LOC100002134 SLC30A8 ENSDARG00000054584 1 Not determined 16
LOC100002543 AKAP2 ENSDARG00000069608 8 Not determined 1
LOC100149598 CHRM3 ENSDARG00000071298 2 Not determined 4
LOC100331214 LPL ENSDARG00000034667 None Not determined 21
LOC100332270 PEX5L ENSDARG00000074403 2 Not determined 1
LOC100333040 ARF5 ENSDARG00000073876 None Not determined 1
LOC100334697 ACHE ENSDARG00000053709 2 Not determined 2
LOC100334833 HMGA2 ENSDARG00000091038 None Not determined 18
LOC555552 RHOU ENSDARG00000005626 None Not determined 5
LOC555807 GALNTL4 ENSDARG00000059438 None Not determined 1
LOC559281 IRS1 ENSDARG00000054087 2 Not determined 7
LOC560642 SLC30A8 ENSDARG00000057629 None Not determined 16
LOC562872 ZPLD1 ENSDARG00000086272 2 Not determined 2
LOC567816 ZPLD1 ENSDARG00000062319 1 Normal 2
LOC794003 ZP4 ENSDARG00000073976 5 Not determined 2
lpl LPL ENSDARG00000087697 1 Not determined 21
LPL (1 of 2) LPL ENSDARG00000091659 2 Not determined 21
maea MAEA ENSDARG00000053691 1 Not determined 2
march1 MARCH1 ENSDARG00000037487 1 Not determined 1
mhc2dab HLA-DRB1 ENSDARG00000079105 None Not determined 35
MR1BB_DANRE MTNR1B ENSDARG00000086493 None Not determined 15
mtnr1ba MTNR1B ENSDARG00000053833 None Not determined 15
mtnr1bb MTNR1B ENSDARG00000086883 None Not determined 15
ndufab1 NDUFAB1 ENSDARG00000014915 None Not determined 1
nkx2.3 NKX2-3 ENSDARG00000039095 None Not determined 10
nkx2.7 NKX2-3 ENSDARG00000021232 1 1 phenotype 10
nod2 NOD2 ENSDARG00000010756 3 Not determined 10
notch2 NOTCH2 ENSDARG00000092960 8 Not determined 1
NOTCH2NL NOTCH2 ENSDARG00000089347 1 Not determined 1
NP_001003748.1 SGCG ENSDARG00000090096 None Not determined 3
NP_001091732.1 HLA-DRB1 ENSDARG00000071168 1 Not determined 35
NP_001108566.1 NOTCH2 ENSDARG00000043130 8 Not determined 1
NP_001165056.1 ADCY5 ENSDARG00000091342 1 Not determined 7
NP_694512.1 MST1 ENSDARG00000031855 2 Not determined 9
nxn NXN ENSDARG00000033978 2 Not determined 2
pabpc1l RBMS1 ENSDARG00000002597 3 Not determined 3
palb2 PALB2 ENSDARG00000076716 4 Not determined 1
pax4 PAX4 ENSDARG00000021336 None Not determined 2
pck1 PCK1 ENSDARG00000013522 None Not determined 2
pepd PEPD ENSDARG00000018020 2 Not determined 3
pls1 PLS1 ENSDARG00000039272 3 Not determined 1
pparg PPARG ENSDARG00000031848 5 2 normal 8
prc1a PRC1 ENSDARG00000010511 None Not determined 1
prc1b PRC1 ENSDARG00000005993 2 Not determined 1
psmd6 PSMD6 ENSDARG00000070674 None Not determined 1
ptpn11a PTPN11 ENSDARG00000020334 2 Not determined 8
ptpn22 PTPN22 ENSDARG00000075062 5 Not determined 17
ptpn2a PTPN2 ENSDARG00000016481 4 Not determined 13
ptpn2b PTPN2 ENSDARG00000035986 2 Not determined 13
PTPRD (2 of 2) PTPRD ENSDARG00000059452 6 Not determined 11
ptprdb PTPRD ENSDARG00000019945 12 Normal 11
r3hdml R3HDML ENSDARG00000030650 None Not determined 1
rbm38 RBM38 ENSDARG00000058818 1 Not determined 3
RBMS1 (2 of 2) RBMS1 ENSDARG00000057768 2 Not determined 3
rbms1a RBMS1 ENSDARG00000074023 None Not determined 3
rhoua RHOU ENSDARG00000019709 4 Not determined 5
rhoub RHOU ENSDARG00000012968 None Not determined 5
rnd3a RND3 ENSDARG00000076799 1 Not determined 1
rnd3b RND3 ENSDARG00000007396 None Not determined 1
RYR2 (1 of 3) RYR2 ENSDARG00000056058 1 Not determined 5
ryr2a RYR2 ENSDARG00000079171 1 Not determined 5
ryr2b RYR2 ENSDARG00000003706 1 Not determined 5
SACS (2 of 2) SACS ENSDARG00000062627 9 Not determined 3
SACS (1 of 2) SACS ENSDARG00000091042 None Not determined 3
sb:cb1008 CUX2 ENSDARG00000086559 2 Not determined 2
sgcg SGCG ENSDARG00000038107 2 Not determined 3
SH2B3 (1 of 2) SH2B3 ENSDARG00000069958 None Not determined 19
si:busm1-104n07.3 HLA-DRB1 ENSDARG00000074510 1 Normal 35
si:busm1-160c18.1 HLA-DQA2 ENSDARG00000053739 2 Not determined 17
si:busm1-160c18.3 HLA-DRB1 ENSDARG00000053738 None Not determined 35
si:busm1-160c18.3 HLA-DRB1 ENSDARG00000093706 None Not determined 35
si:busm1-194e12.11 HLA-DQA2 ENSDARG00000055441 1 Not determined 17
si:busm1-194e12.12 HLA-DRB1 ENSDARG00000055447 None Not determined 35
si:busm1-228j01.3 HLA-DQA2 ENSDARG00000086294 2 Not determined 17
si:busm1-228j01.4 HLA-DRB1 ENSDARG00000088872 2 Not determined 35
si:busm1-228j01.5 HLA-DQA2 ENSDARG00000079593 3 Not determined 17
si:busm1-228j01.6 HLA-DRB1 ENSDARG00000041705 1 Not determined 35
si:busm1-265n4.4 C6orf57 ENSDARG00000039390 None Not determined 1
si:ch1073-403i13.1 HLA-DQA2 ENSDARG00000001832 None Not determined 17
si:ch211-120p12.4 PCNXL2 ENSDARG00000055698 10 Normal 1
si:ch211-127m10.2 BCL11A ENSDARG00000063153 3 Not determined 10
si:ch211-197l9.5 HUNK ENSDARG00000086679 1 Not determined 3
si:ch211-218i18.2 CUX2 ENSDARG00000086345 None Not determined 2
si:ch211-71n6.4 ACHE ENSDARG00000088003 None Not determined 2
si:ch73-125n14.1 TMEM163 ENSDARG00000088227 None Not determined 1
si:ch73-211l2.3 HLA-DQA2 ENSDARG00000075932 1 Not determined 17
si:ch73-233m11.2 NOD2 ENSDARG00000091859 None Not determined 10
si:dkey-108d22.4 BSN ENSDARG00000063299 14 Normal 4
si:dkey-149g8.1 PEX5L ENSDARG00000022518 3 Not determined 1
si:dkey-189i22.2 HUNK ENSDARG00000091317 None Not determined 3
si:dkey-266j7.1 BSN ENSDARG00000012482 16 Not determined 4
si:dkey-30c15.17 ACHE ENSDARG00000058492 1 Normal 2
si:dkey-78k11.2 CR2 ENSDARG00000095512 None Not determined 1
si:dkeyp-106c3.3 APOB ENSDARG00000093159 None Not determined 17
si:dkeyp-118h9.7 SACS ENSDARG00000075668 11 Not determined 3
si:dkeyp-1e8.2 SH2B3 ENSDARG00000093095 None Not determined 19
si:dkeyp-2h4.2 HLA-DQA2 ENSDARG00000031745 None Not determined 17
si:dkeyp-88f5.1 APOB ENSDARG00000075016 5 Not determined 17
si:rp71-56i13.1 ZPLD1 ENSDARG00000076438 1 Not determined 2
si:rp71-80a19.2 MAP3K1 ENSDARG00000088180 None Not determined 5
si:zfos-2070c2.1 HLA-DQA2 ENSDARG00000070206 None Not determined 17
si:zfos-2070c2.3 HLA-DRB1 ENSDARG00000076307 None Not determined 35
si:zfos-367g9.1 HLA-DQA2 ENSDARG00000074816 1 Not determined 17
snd1 SND1 ENSDARG00000006766 6 Not determined 1
spry2 SPRY2 ENSDARG00000078308 1 Not determined 5
st6gal1 ST6GAL1 ENSDARG00000044514 2 Not determined 4
syk SYK ENSDARG00000008186 2 Not determined 4
TCERG1L TCERG1L ENSDARG00000087127 None Not determined 4
tcf7l2 TCF7L2 ENSDARG00000004415 5 Not determined 23
TGFBR3 TGFBR3 ENSDARG00000078670 2 Not determined 4
tmem163 TMEM163 ENSDARG00000079858 2 Not determined 1
tmem45b TMEM45B ENSDARG00000056239 1 Not determined 3
tp53inp1 TP53INP1 ENSDARG00000028017 2 Not determined 1
vegfaa VEGFA ENSDARG00000045971 None Not determined 8
vegfab VEGFA ENSDARG00000034700 None Not determined 8
vps26a VPS26A ENSDARG00000056549 None Not determined 2
WFS1 (1 of 2) WFS1 ENSDARG00000062341 3 Not determined 2
wisp1a WISP1 ENSDARG00000054331 3 Not determined 1
wisp1b WISP1 ENSDARG00000076685 1 Not determined 1
wu:fd58b11 HLA-DRB1 ENSDARG00000054921 None Not determined 35
wwox WWOX ENSDARG00000007614 4 Not determined 9
zgc:101121 ZFAND6 ENSDARG00000033811 2 Not determined 1
zgc:110105 ZFAND3 ENSDARG00000052833 1 Not determined 2
zgc:110286 ARF5 ENSDARG00000074210 1 Not determined 1
zgc:110775 CR2 ENSDARG00000056075 1 Not determined 1
zgc:113068 THADA ENSDARG00000053082 2 Not determined 10
zgc:123107 HLA-DQA2 ENSDARG00000020286 None Not determined 17
zgc:123305 LPIN2 ENSDARG00000015563 None Not determined 1
zgc:153067 HLA-DRB1 ENSDARG00000056330 2 Not determined 35
zgc:158252 AKAP2 ENSDARG00000071215 None Not determined 1
zgc:158252 PALM2 ENSDARG00000071215 None Not determined 1
zgc:162228 TRAFD1 ENSDARG00000075123 None Not determined 2
zgc:162595 C2CD4B ENSDARG00000061416 None Not determined 5
zgc:162595 C2CD4A ENSDARG00000061416 None Not determined 4
zgc:172284 CAMK1D ENSDARG00000074905 4 Not determined 4
zgc:56306 IRS1 ENSDARG00000037099 1 Not determined 7
zgc:77650 ARF5 ENSDARG00000042382 3 Not determined 1
zgc:86764 PRC1 ENSDARG00000005098 None Not determined 1
zgc:92607 NDUFAB1 ENSDARG00000058463 None Not determined 1
zp2 ZP4 ENSDARG00000086352 1 Not determined 2
zp2 ZP4 ENSDARG00000089966 None Not determined 2
zp2.2 ZP4 ENSDARG00000091737 None Not determined 2
zp2.3 ZP4 ENSDARG00000090237 None Not determined 2
zp2.5 ZP4 ENSDARG00000086522 None Not determined 2
zp2.6 ZP4 ENSDARG00000091409 None Not determined 2
zp2l1 ZP4 ENSDARG00000055415 1 Not determined 2
zp2l2 ZP4 ENSDARG00000004898 None Not determined 2
ZPLD1 (1 of 2) ZPLD1 ENSDARG00000061835 1 Not determined 2

The following reported genes could not be linked automatically to a zebrafish gene:

  • ADAM30
  • ANK1
  • APOE cluster
  • C14orf70
  • CDKAL
  • CENTD2
  • CHCHD9
  • CMIP
  • CTCFL
  • DCD
  • FLJ16165
  • GRK5
  • HHEX
  • HHEX
  • HHEX
  • HHEX
  • HHEX
  • HHEX
  • HHEX
  • HHEX
  • HHEX
  • HMG1L1
  • IG2BP2
  • IL23R
  • IL23R
  • IL2RA
  • KCNK16
  • KIAA0350
  • KIF11
  • KLF14
  • LGR5
  • LGR5
  • LNK
  • LOC729013
  • MGC21675
  • MHC
  • MHC
  • RASGRP1
  • RBM43
  • SLC44A3
  • SRR
  • SYN2
  • TCF2
  • TSPAN8
  • TSPAN8
  • ZBED3
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