GWAS

(GWAS data used on the Zebrafish Mutation Project Web site comes from http://www.genome.gov/gwastudies/.)

Rheumatoid arthritis

The human homologues of the following genes have been identified in "Rheumatoid arthritis" studies:

Gene name Reported Gene Ensembl ID Alleles found Associated phenotype Study Count
A5D6S4_DANRE C5 ENSDARG00000021004 8 Not determined 2
aire AIRE ENSDARG00000056784 2 Normal 1
ankrd55 ANKRD55 ENSDARG00000053869 5 Not determined 6
anxa3a ANXA3 ENSDARG00000009196 2 Not determined 2
anxa3b ANXA3 ENSDARG00000044254 None Not determined 2
ARAP1 (3 of 3) ARAP1 ENSDARG00000087470 None Not determined 3
ARAP1 (1 of 3) ARAP1 ENSDARG00000091634 None Not determined 3
arhgef3 ARHGEF3 ENSDARG00000013834 2 Not determined 6
arhgef3l ARHGEF3 ENSDARG00000037554 2 Not determined 6
ARID5B ARID5B ENSDARG00000037196 2 Not determined 7
bltk BLK ENSDARG00000007783 2 Not determined 11
ccr6a CCR6 ENSDARG00000087474 4 Not determined 7
ccr6b CCR6 ENSDARG00000038968 2 Not determined 7
cd247l CD247 ENSDARG00000077240 1 Not determined 6
fli1a FLI1 ENSDARG00000054632 1 Not determined 3
fli1b FLI1 ENSDARG00000040080 1 Not determined 3
GCH1 GCH1 ENSDARG00000070453 1 Not determined 2
gch2 GCH1 ENSDARG00000013340 None Not determined 2
ik:tdsubc_1e8 RBPJ ENSDARG00000003398 None Not determined 1
il2rb IL2RB ENSDARG00000075720 3 Not determined 3
il6st IL6ST ENSDARG00000030498 5 Normal 3
irf5 IRF5 ENSDARG00000045681 None Not determined 14
irf8 IRF8 ENSDARG00000056407 None Not determined 9
kif5a KIF5A ENSDARG00000005470 3 Not determined 1
LOC100332468 PDE2A ENSDARG00000079064 None Not determined 2
LOC100332526 ARAP1 ENSDARG00000086356 1 Not determined 3
LOC558432 SPRED2 ENSDARG00000052435 2 Not determined 3
LOC558930 B3GNT2 ENSDARG00000089094 1 Not determined 2
LOC560703 MMEL1 ENSDARG00000026398 3 Not determined 6
LOC569515 CDK6 ENSDARG00000030163 2 Not determined 8
LOC570106 PFKL ENSDARG00000060504 2 Not determined 1
LOC799274 KIF5A ENSDARG00000059818 4 Not determined 1
mhc2dab HLA-DRB1 ENSDARG00000079105 None Not determined 35
NP_001091732.1 HLA-DRB1 ENSDARG00000071168 1 Not determined 35
olig3 OLIG3 ENSDARG00000074253 None Not determined 5
olig4 OLIG3 ENSDARG00000052610 1 Normal 5
PDE2A (2 of 2) PDE2A ENSDARG00000091508 None Not determined 2
PIP4K2C (2 of 2) PIP4K2C ENSDARG00000091637 None Not determined 1
pip5k2 PIP4K2C ENSDARG00000031020 2 Not determined 1
PLD4 PLD4 ENSDARG00000075770 1 Not determined 1
pou3f3a POU3F1 ENSDARG00000042032 1 Not determined 3
prkcha PRKCH ENSDARG00000018382 1 Not determined 1
prkchb PRKCH ENSDARG00000043243 3 Not determined 1
prkcq PRKCQ ENSDARG00000034173 3 Not determined 6
ptpn22 PTPN22 ENSDARG00000075062 5 Not determined 17
ptpn2a PTPN2 ENSDARG00000016481 4 Not determined 13
ptpn2b PTPN2 ENSDARG00000035986 2 Not determined 13
pxk PXK ENSDARG00000063195 2 Not determined 2
rbpjb RBPJ ENSDARG00000052091 2 Not determined 1
rel REL ENSDARG00000055276 4 Not determined 10
rtkn2 RTKN2 ENSDARG00000053558 2 Not determined 3
sall3 SALL3 ENSDARG00000079613 None Not determined 2
SH2B3 (1 of 2) SH2B3 ENSDARG00000069958 None Not determined 19
si:busm1-104n07.3 HLA-DRB1 ENSDARG00000074510 1 Normal 35
si:busm1-160c18.1 HLA-DQA1 ENSDARG00000053739 2 Not determined 27
si:busm1-160c18.1 HLA-DRA ENSDARG00000053739 2 Not determined 21
si:busm1-160c18.1 HLA-DQA2 ENSDARG00000053739 2 Not determined 17
si:busm1-160c18.3 HLA-DRB1 ENSDARG00000053738 None Not determined 35
si:busm1-160c18.3 HLA-DRB1 ENSDARG00000093706 None Not determined 35
si:busm1-194e12.11 HLA-DQA1 ENSDARG00000055441 1 Not determined 27
si:busm1-194e12.11 HLA-DRA ENSDARG00000055441 1 Not determined 21
si:busm1-194e12.11 HLA-DQA2 ENSDARG00000055441 1 Not determined 17
si:busm1-194e12.12 HLA-DRB1 ENSDARG00000055447 None Not determined 35
si:busm1-228j01.3 HLA-DQA1 ENSDARG00000086294 2 Not determined 27
si:busm1-228j01.3 HLA-DRA ENSDARG00000086294 2 Not determined 21
si:busm1-228j01.3 HLA-DQA2 ENSDARG00000086294 2 Not determined 17
si:busm1-228j01.4 HLA-DRB1 ENSDARG00000088872 2 Not determined 35
si:busm1-228j01.5 HLA-DQA1 ENSDARG00000079593 3 Not determined 27
si:busm1-228j01.5 HLA-DRA ENSDARG00000079593 3 Not determined 21
si:busm1-228j01.5 HLA-DQA2 ENSDARG00000079593 3 Not determined 17
si:busm1-228j01.6 HLA-DRB1 ENSDARG00000041705 1 Not determined 35
si:ch1073-403i13.1 HLA-DQA1 ENSDARG00000001832 None Not determined 27
si:ch1073-403i13.1 HLA-DRA ENSDARG00000001832 None Not determined 21
si:ch1073-403i13.1 HLA-DQA2 ENSDARG00000001832 None Not determined 17
si:ch211-135f11.1 ARAP1 ENSDARG00000062221 None Not determined 3
si:ch211-149p5.1 TRHDE ENSDARG00000076044 2 Not determined 2
si:ch211-153j24.4 BATF ENSDARG00000011818 None Not determined 2
si:ch211-160b7.1 CTLA4 ENSDARG00000095070 None Not determined 9
si:ch211-198g19.1 TRHDE ENSDARG00000062013 5 Not determined 2
si:ch211-213b8.3 B3GNT2 ENSDARG00000052376 1 Not determined 2
si:ch211-234f14.1 CDK6 ENSDARG00000070228 None Not determined 8
si:ch211-235o23.2 APOM ENSDARG00000076838 2 Not determined 2
si:ch211-274c22.6 TNFAIP3 ENSDARG00000027777 5 Not determined 11
si:ch73-211l2.3 HLA-DQA2 ENSDARG00000075932 1 Not determined 17
si:ch73-211l2.3 HLA-DQA1 ENSDARG00000075932 1 Not determined 27
si:ch73-211l2.3 HLA-DRA ENSDARG00000075932 1 Not determined 21
si:dkey-175m17.6 B3GNT2 ENSDARG00000088601 1 Not determined 2
si:dkey-195c14.1 SALL3 ENSDARG00000057586 2 Not determined 2
si:dkey-19j7.2 AFF3 ENSDARG00000079575 11 Not determined 3
si:dkeyp-1e8.2 SH2B3 ENSDARG00000093095 None Not determined 19
si:dkeyp-2h4.2 HLA-DQA2 ENSDARG00000031745 None Not determined 17
si:dkeyp-2h4.2 HLA-DQA1 ENSDARG00000031745 None Not determined 27
si:dkeyp-2h4.2 HLA-DRA ENSDARG00000031745 None Not determined 21
si:zfos-2070c2.1 HLA-DQA1 ENSDARG00000070206 None Not determined 27
si:zfos-2070c2.1 HLA-DRA ENSDARG00000070206 None Not determined 21
si:zfos-2070c2.1 HLA-DQA2 ENSDARG00000070206 None Not determined 17
si:zfos-2070c2.3 HLA-DRB1 ENSDARG00000076307 None Not determined 35
si:zfos-367g9.1 HLA-DRA ENSDARG00000074816 1 Not determined 21
si:zfos-367g9.1 HLA-DQA2 ENSDARG00000074816 1 Not determined 17
si:zfos-367g9.1 HLA-DQA1 ENSDARG00000074816 1 Not determined 27
spred2 SPRED2 ENSDARG00000008372 1 Not determined 3
stat4 STAT4 ENSDARG00000028731 3 Not determined 19
traf1 TRAF1 ENSDARG00000069482 1 Not determined 3
wu:fd58b11 HLA-DRB1 ENSDARG00000054921 None Not determined 35
zgc:110298 PFKL ENSDARG00000042375 None Not determined 1
zgc:113947 B3GNT2 ENSDARG00000091902 None Not determined 2
zgc:123107 HLA-DQA1 ENSDARG00000020286 None Not determined 27
zgc:123107 HLA-DRA ENSDARG00000020286 None Not determined 21
zgc:123107 HLA-DQA2 ENSDARG00000020286 None Not determined 17
zgc:153067 HLA-DRB1 ENSDARG00000056330 2 Not determined 35
zgc:158276 NFKBIE ENSDARG00000068367 None Not determined 2
zgc:158706 ARID5B ENSDARG00000069988 None Not determined 7
zgc:194281 C5orf30 ENSDARG00000093498 None Not determined 1
zgc:66317 PADI4 ENSDARG00000044167 2 Not determined 3
zgc:77151 ARID5B ENSDARG00000054307 1 Not determined 7

The following reported genes could not be linked automatically to a zebrafish gene:

  • CCL21
  • CCL21
  • CD40
  • CD40
  • CD83
  • CSF2
  • ETS1
  • HLA locus
  • HLA-G
  • IKZF3
  • IL2
  • IL21
  • IL2RA
  • KIF3
  • MICA
  • PRKCB1
  • TNFIP3
  • TNFRSF14
  • TNFRSF14
  • TRAF1-C5
  • UBASH3A
  • ZNF774
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