GWAS

(GWAS data used on the Zebrafish Mutation Project Web site comes from http://www.genome.gov/gwastudies/.)

Multiple sclerosis

The human homologues of the following genes have been identified in "Multiple sclerosis" studies:

Gene name Reported Gene Ensembl ID Alleles found Associated phenotype Study Count
ahi1 AHI1 ENSDARG00000044056 4 Not determined 1
alpk2 ALPK2 ENSDARG00000079637 None Not determined 1
ARHGEF10 ARHGEF10 ENSDARG00000077788 2 Not determined 1
arl11 ARL11 ENSDARG00000036637 1 Not determined 1
asap1 ASAP1 ENSDARG00000002607 6 Normal 1
asap1 ASAP1 ENSDARG00000039729 3 Not determined 1
bach2 BACH2 ENSDARG00000004074 2 Not determined 14
cblb CBLB ENSDARG00000015199 1 Not determined 1
CDC37 CDC37 ENSDARG00000040126 None Not determined 1
chst12 CHST12 ENSDARG00000028786 None Not determined 1
cmyb MYB ENSDARG00000053666 2 Not determined 12
crfb9 IL22RA2 ENSDARG00000039439 3 Not determined 1
cxcr3.2 CXCR5 ENSDARG00000041041 3 Not determined 4
cxcr4a CXCR4 ENSDARG00000057633 1 Not determined 2
cxcr4b CXCR4 ENSDARG00000041959 None Not determined 2
cyp24a1l CYP24A1 ENSDARG00000070420 None Not determined 2
CYP27B1 CYP27B1 ENSDARG00000045015 1 Not determined 2
dsc2l DSC1 ENSDARG00000039677 3 Not determined 1
egfl6 EGFL6 ENSDARG00000045958 2 Not determined 1
eomesa EOMES ENSDARG00000006640 1 Not determined 2
eomesb EOMES ENSDARG00000019428 3 Not determined 2
evi5 EVI5 ENSDARG00000070839 1 Not determined 3
FBXO48 FBXO48 ENSDARG00000086184 None Not determined 1
GPR65 GPR65 ENSDARG00000045957 1 Not determined 3
HACE1 HACE1 ENSDARG00000062280 4 Not determined 6
il12ba IL12B ENSDARG00000033727 2 Not determined 14
il7r IL7R ENSDARG00000078970 None Not determined 7
ildr1 ILDR1 ENSDARG00000040910 None Not determined 1
irf8 IRF8 ENSDARG00000056407 None Not determined 9
kif1b KIF1B ENSDARG00000037020 7 Not determined 3
kpnb1 KPNB1 ENSDARG00000008680 None Not determined 1
LOC100001799 IL12B ENSDARG00000069504 1 Not determined 14
LOC100004261 MAP3K14 ENSDARG00000074060 5 Not determined 1
LOC100331766 MANBA ENSDARG00000079520 None Not determined 2
LOC100332016 SOX8 ENSDARG00000068019 1 Not determined 1
LOC100332780 ZMIZ1 ENSDARG00000076477 3 Not determined 10
LOC100334375 DBC1 ENSDARG00000078302 2 Not determined 2
LOC555649 SP140 ENSDARG00000090449 4 Not determined 4
LOC557210 BACH2 ENSDARG00000036569 4 Not determined 14
LOC559568 TBKBP1 ENSDARG00000061473 3 Not determined 2
LOC560512 PVR ENSDARG00000077419 None Not determined 1
LOC560703 MMEL1 ENSDARG00000026398 3 Not determined 6
LOC560816 PVR ENSDARG00000062831 None Not determined 1
LOC563218 C16orf75 ENSDARG00000074444 None Not determined 2
LOC570502 KIF21B ENSDARG00000009733 8 Not determined 5
LOC799019 CXCR5 ENSDARG00000010514 1 Not determined 4
maf MAF ENSDARG00000015890 None Not determined 8
MAF (1 of 2) MAF ENSDARG00000076520 1 Not determined 8
malt1 MALT1 ENSDARG00000006052 None Not determined 1
manba MANBA ENSDARG00000008238 None Not determined 2
mapk1 MAPK1 ENSDARG00000027552 1 Not determined 2
mertk MERTK ENSDARG00000074695 5 Normal 2
mhc2dab HLA-DQB1 ENSDARG00000079105 None Not determined 24
mhc2dab HLA-DRB1 ENSDARG00000079105 None Not determined 35
MPHOSPH9 MPHOSPH9 ENSDARG00000079091 None Not determined 1
mpv17l2 MPV17L2 ENSDARG00000056367 1 Not determined 1
myca MYC ENSDARG00000045695 None Not determined 7
mycb MYC ENSDARG00000007241 None Not determined 7
mych MYC ENSDARG00000077473 None Not determined 7
mynn MYNN ENSDARG00000007271 4 Not determined 2
ndfip1 NDFIP1 ENSDARG00000013979 None Not determined 4
ndfip1l NDFIP1 ENSDARG00000008057 None Not determined 4
NFKBIZ NFKBIZ ENSDARG00000095117 None Not determined 1
NP_001091732.1 HLA-DQB1 ENSDARG00000071168 1 Not determined 24
NP_001091732.1 HLA-DRB1 ENSDARG00000071168 1 Not determined 35
odf3b ODF3B ENSDARG00000042391 1 Not determined 3
olig3 OLIG3 ENSDARG00000074253 None Not determined 5
olig4 OLIG3 ENSDARG00000052610 1 Normal 5
plcl2 PLCL2 ENSDARG00000075247 1 Not determined 2
plek PLEK ENSDARG00000017298 1 Not determined 4
popdc3 POPDC3 ENSDARG00000058551 None Not determined 3
ptger4a PTGER4 ENSDARG00000059236 2 Normal 12
ptger4b PTGER4 ENSDARG00000035415 1 Not determined 12
ptprk PTPRK ENSDARG00000063416 1 Not determined 2
pvrl2l PVR ENSDARG00000063390 1 Not determined 1
pvrl4 PVR ENSDARG00000094356 None Not determined 1
RGS14 (1 of 2) RGS14 ENSDARG00000060200 1 Not determined 5
rgs14a RGS14 ENSDARG00000021521 None Not determined 5
rpl5a RPL5 ENSDARG00000020197 None Not determined 3
rpl5b RPL5 ENSDARG00000015862 1 Not determined 3
rps6kb1 RPS6KB1 ENSDARG00000058230 6 Not determined 3
sae1 SAE1 ENSDARG00000010487 1 Not determined 1
sco2 SCO2 ENSDARG00000045555 1 Not determined 2
si:busm1-104n07.3 HLA-DRB1 ENSDARG00000074510 1 Normal 35
si:busm1-104n07.3 HLA-DQB1 ENSDARG00000074510 1 Normal 24
si:busm1-160c18.1 HLA-DRA ENSDARG00000053739 2 Not determined 21
si:busm1-160c18.3 HLA-DRB1 ENSDARG00000053738 None Not determined 35
si:busm1-160c18.3 HLA-DQB1 ENSDARG00000053738 None Not determined 24
si:busm1-160c18.3 HLA-DRB1 ENSDARG00000093706 None Not determined 35
si:busm1-160c18.3 HLA-DQB1 ENSDARG00000093706 None Not determined 24
si:busm1-194e12.11 HLA-DRA ENSDARG00000055441 1 Not determined 21
si:busm1-194e12.12 HLA-DQB1 ENSDARG00000055447 None Not determined 24
si:busm1-194e12.12 HLA-DRB1 ENSDARG00000055447 None Not determined 35
si:busm1-228j01.3 HLA-DRA ENSDARG00000086294 2 Not determined 21
si:busm1-228j01.4 HLA-DQB1 ENSDARG00000088872 2 Not determined 24
si:busm1-228j01.4 HLA-DRB1 ENSDARG00000088872 2 Not determined 35
si:busm1-228j01.5 HLA-DRA ENSDARG00000079593 3 Not determined 21
si:busm1-228j01.6 HLA-DQB1 ENSDARG00000041705 1 Not determined 24
si:busm1-228j01.6 HLA-DRB1 ENSDARG00000041705 1 Not determined 35
si:ch1073-403i13.1 HLA-DRA ENSDARG00000001832 None Not determined 21
si:ch211-121h11.2 SAMD12 ENSDARG00000069973 None Not determined 1
si:ch211-141e20.2 PVR ENSDARG00000093349 None Not determined 1
si:ch211-152p11.4 RGS1 ENSDARG00000079705 3 Not determined 3
si:ch211-153j24.4 BATF ENSDARG00000011818 None Not determined 2
si:ch211-160i2.3 ASAP1 ENSDARG00000029463 2 Not determined 1
si:ch211-163l21.4 C1orf106 ENSDARG00000078155 1 Not determined 3
si:ch211-210g13.5 PLCL2 ENSDARG00000062575 5 Not determined 2
si:ch211-213n8.3 IL12B ENSDARG00000054542 1 Not determined 14
si:ch211-214p13.3 PVR ENSDARG00000087403 1 Not determined 1
si:ch211-216l23.2 NCOA5 ENSDARG00000069122 2 Not determined 1
si:ch211-222f23.6 PVR ENSDARG00000042880 1 Not determined 1
si:ch211-234e14.2 PTGER4 ENSDARG00000079907 None Not determined 12
si:ch211-251n20.3 RGS1 ENSDARG00000089077 None Not determined 3
si:ch211-253b1.4 MAP3K14 ENSDARG00000056582 None Not determined 1
si:ch211-261c8.3 MALT1 ENSDARG00000077768 3 Not determined 1
si:ch211-266d19.3 RREB1 ENSDARG00000063701 1 Not determined 6
si:ch211-279l9.6 RREB1 ENSDARG00000042652 5 Not determined 6
si:ch73-211l2.3 HLA-DRA ENSDARG00000075932 1 Not determined 21
si:dkey-149m16.2 RPS6KB1 ENSDARG00000018399 2 Not determined 3
si:dkey-18l1.1 KIAA0564 ENSDARG00000078593 5 Not determined 1
si:dkey-26i13.10 CHST12 ENSDARG00000077198 1 Not determined 1
si:dkey-26i13.3 CHST12 ENSDARG00000095482 None Not determined 1
si:dkey-26i13.4 CHST12 ENSDARG00000094981 1 Not determined 1
si:dkey-26i13.5 CHST12 ENSDARG00000093636 None Not determined 1
si:dkey-26i13.6 CHST12 ENSDARG00000092200 None Not determined 1
si:dkey-26i13.7 CHST12 ENSDARG00000092242 1 Not determined 1
si:dkey-281i8.1 PVR ENSDARG00000069936 None Not determined 1
si:dkey-60b12.3 EXTL2 ENSDARG00000063191 1 Not determined 1
si:dkey-60b12.4 VCAM1 ENSDARG00000078201 None Not determined 1
si:dkey-77f17.1 MALT1 ENSDARG00000068152 4 Not determined 1
si:dkey-8e10.2 CD6 ENSDARG00000069542 4 Not determined 4
si:dkey-90a13.6 ZBTB46 ENSDARG00000078191 1 Not determined 3
si:dkeyp-116h7.3 VAV2 ENSDARG00000044718 None Not determined 2
si:dkeyp-192m14.7 EPS15L1 ENSDARG00000042670 4 Not determined 2
si:dkeyp-2h4.2 HLA-DRA ENSDARG00000031745 None Not determined 21
si:dkeyp-75b4.11 TRIM2 ENSDARG00000076174 None Not determined 1
si:zfos-2070c2.1 HLA-DRA ENSDARG00000070206 None Not determined 21
si:zfos-2070c2.3 HLA-DQB1 ENSDARG00000076307 None Not determined 24
si:zfos-2070c2.3 HLA-DRB1 ENSDARG00000076307 None Not determined 35
si:zfos-367g9.1 HLA-DRA ENSDARG00000074816 1 Not determined 21
slc15a2 SLC15A2 ENSDARG00000032010 2 Not determined 1
slc30a7 SLC30A7 ENSDARG00000019998 None Not determined 1
sox8 SOX8 ENSDARG00000037782 None Not determined 1
stat3 STAT3 ENSDARG00000022712 5 Not determined 7
syk SYK ENSDARG00000008186 2 Not determined 4
tagap TAGAP ENSDARG00000043475 4 Not determined 7
tbx21 TBX21 ENSDARG00000004473 None Not determined 1
tcf7 TCF7 ENSDARG00000038672 1 Not determined 1
themis THEMIS ENSDARG00000010619 4 Not determined 2
tll1 TLL1 ENSDARG00000037429 2 1 phenotype 2
tnfrsf1a TNFRSF1A ENSDARG00000018569 2 Not determined 3
TNFRSF1A (1 of 2) TNFRSF1A ENSDARG00000090478 None Not determined 3
TYK2 TYK2 ENSDARG00000020326 4 Not determined 6
vcam1 VCAM1 ENSDARG00000062479 5 Not determined 1
vti1a VTI1A ENSDARG00000045065 None Not determined 3
wu:fd58b11 HLA-DRB1 ENSDARG00000054921 None Not determined 35
wu:fd58b11 HLA-DQB1 ENSDARG00000054921 None Not determined 24
ywhag1 YWHAG ENSDARG00000067626 1 Not determined 1
ywhag2 YWHAG ENSDARG00000071658 1 Not determined 1
zfp36l1a ZFP36L1 ENSDARG00000016154 None Not determined 4
zfp36l1b ZFP36L1 ENSDARG00000021443 None Not determined 4
zfp438 ZNF438 ENSDARG00000061311 None Not determined 1
zgc:103636 METTL1 ENSDARG00000076518 None Not determined 1
zgc:110196 C3orf1 ENSDARG00000053466 2 Not determined 2
zgc:113068 THADA ENSDARG00000053082 2 Not determined 10
zgc:113099 TRIM2 ENSDARG00000031817 1 Not determined 1
zgc:113279 NFKBIZ ENSDARG00000058263 1 Not determined 1
zgc:113411 SP140 ENSDARG00000038133 1 Not determined 4
zgc:123107 HLA-DRA ENSDARG00000020286 None Not determined 21
zgc:153067 HLA-DQB1 ENSDARG00000056330 2 Not determined 24
zgc:153067 HLA-DRB1 ENSDARG00000056330 2 Not determined 35
zgc:153779 AGAP2 ENSDARG00000061117 6 Not determined 1
zgc:153953 C1orf106 ENSDARG00000070571 2 Not determined 3
zgc:171579 GPR65 ENSDARG00000039234 2 Not determined 3
zgc:56230 CLEC16A ENSDARG00000038094 3 Not determined 13
zgc:63990 TMEM47 ENSDARG00000057322 1 Not determined 1
zgc:64227 ILDR1 ENSDARG00000090704 None Not determined 1
zgc:65781 TMEM39A ENSDARG00000070643 None Not determined 1
zgc:77799 TAGAP ENSDARG00000002353 None Not determined 7
zgc:85829 DDAH1 ENSDARG00000069591 None Not determined 1
zgc:92194 NCOA5 ENSDARG00000016345 4 Not determined 1
zmiz1 ZMIZ1 ENSDARG00000074502 10 Not determined 10

The following reported genes could not be linked automatically to a zebrafish gene:

  • AK127238
  • C2orf13
  • C6orf10
  • CD40
  • CD40
  • CD40
  • CD5
  • CD58
  • CD58
  • CD58
  • CD58
  • CD58
  • CD86
  • CD86
  • CD86
  • CD86
  • CLECL1
  • DDEF1
  • DKKL1
  • DLEU1
  • DQA1
  • DRB1
  • DRB1
  • DRB1
  • DRB1
  • FCRL3
  • HHEX
  • HLA
  • HLA
  • HLA-B
  • HLA-B
  • HLA-DRB
  • IL12A
  • IL12A
  • IL2RA
  • IL2RA
  • IL2RA
  • IL2RA
  • IL2RA
  • IL2RA
  • IL7
  • IL7RA
  • KIAA0350
  • LOC100289506
  • LOC100289506
  • LOC285501
  • LOC339788
  • MAMSTR
  • MLANA
  • MMP10
  • MRGPRE
  • NAP5
  • NFKB1
  • PKIA
  • PRM1
  • PRM2
  • PRM3
  • PVT1
  • RNASEL
  • TNFSF14
  • TNP2
  • ZNF433
  • ZNF746
  • ZNF767
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