GWAS

(GWAS data used on the Zebrafish Mutation Project Web site comes from http://www.genome.gov/gwastudies/.)

Age-related macular degeneration

The human homologues of the following genes have been identified in "Age-related macular degeneration" studies:

Gene name Reported Gene Ensembl ID Alleles found Associated phenotype Study Count
A1L2D9_DANRE CFI ENSDARG00000036900 1 Not determined 4
A4QP95_DANRE C2 ENSDARG00000019772 4 Not determined 5
apoeb APOE ENSDARG00000040295 1 Not determined 42
aspm ASPM ENSDARG00000071442 19 Not determined 1
bfb CFB ENSDARG00000005616 3 Not determined 6
C3 (1 of 9) C3 ENSDARG00000090176 None Not determined 6
c3b C3 ENSDARG00000087359 8 Not determined 6
c3c C3 ENSDARG00000052207 3 Not determined 6
cetp CETP ENSDARG00000030872 2 Not determined 27
cfb CFB ENSDARG00000055278 4 Not determined 6
cfh CFH ENSDARG00000075761 3 Not determined 12
cfh CFHR3 ENSDARG00000075761 3 Not determined 4
cfh CFHR4 ENSDARG00000075761 3 Not determined 3
cfh CFHR2 ENSDARG00000075761 3 Not determined 1
cfh CFHR5 ENSDARG00000075761 3 Not determined 2
cfhl1 CFH ENSDARG00000056771 2 Not determined 12
cfhl1 CFHR3 ENSDARG00000056771 2 Not determined 4
cfhl1 CFHR4 ENSDARG00000056771 2 Not determined 3
cfhl1 CFHR2 ENSDARG00000056771 2 Not determined 1
cfhl1 CFHR5 ENSDARG00000056771 2 Not determined 2
cfhl2 CFH ENSDARG00000056778 4 Not determined 12
cfhl2 CFHR3 ENSDARG00000056778 4 Not determined 4
cfhl2 CFHR4 ENSDARG00000056778 4 Not determined 3
cfhl2 CFHR2 ENSDARG00000056778 4 Not determined 1
cfhl2 CFHR5 ENSDARG00000056778 4 Not determined 2
cfhl3 CFH ENSDARG00000094661 None Not determined 12
cfhl3 CFHR3 ENSDARG00000094661 None Not determined 4
cfhl3 CFHR4 ENSDARG00000094661 None Not determined 3
cfhl3 CFHR2 ENSDARG00000094661 None Not determined 1
cfhl3 CFHR5 ENSDARG00000094661 None Not determined 2
cfhl4 CFHR3 ENSDARG00000094496 None Not determined 4
cfhl4 CFHR4 ENSDARG00000094496 None Not determined 3
cfhl4 CFHR2 ENSDARG00000094496 None Not determined 1
cfhl4 CFHR5 ENSDARG00000094496 None Not determined 2
cfhl4 CFH ENSDARG00000094496 None Not determined 12
col10a1 COL10A1 ENSDARG00000054753 3 Not determined 1
col8a1a COL8A1 ENSDARG00000077403 3 Not determined 1
col8a1b COL8A1 ENSDARG00000003533 2 Not determined 1
dapk3 DAPK3 ENSDARG00000074447 1 Normal 1
F13B F13B ENSDARG00000086724 1 Not determined 2
fam84b FAM84B ENSDARG00000032859 None Not determined 2
FRK FRK ENSDARG00000027807 1 Not determined 3
gli2a GLI2 ENSDARG00000025641 8 Not determined 3
gli2b GLI2 ENSDARG00000020884 6 Not determined 3
gli3 GLI3 ENSDARG00000052131 7 Normal 2
hbl1 MBL2 ENSDARG00000068221 None Not determined 2
hbl2 MBL2 ENSDARG00000094681 1 Not determined 2
hbl3 MBL2 ENSDARG00000068220 1 Not determined 2
hbl4 MBL2 ENSDARG00000054202 None Not determined 2
hdr TNFRSF10A ENSDARG00000004392 2 Not determined 1
htra1a HTRA1 ENSDARG00000032831 5 Normal 9
htra1b HTRA1 ENSDARG00000014907 4 Not determined 9
igfbp7 IGFBP7 ENSDARG00000017389 None Not determined 1
inhbb INHBB ENSDARG00000040777 1 Not determined 4
itgb1bp3 ITGB1BP3 ENSDARG00000067848 1 Not determined 1
KCNT2 (2 of 2) KCNT2 ENSDARG00000091352 None Not determined 2
lipc LIPC ENSDARG00000053476 2 Not determined 24
LIPC (2 of 2) LIPC ENSDARG00000090486 None Not determined 24
LOC100331428 C3 ENSDARG00000093198 None Not determined 6
LOC555897 TRPC4 ENSDARG00000070507 3 Not determined 2
LOC560512 PVRL2 ENSDARG00000077419 None Not determined 9
LOC560816 PVRL2 ENSDARG00000062831 None Not determined 9
LOC565691 KCNT2 ENSDARG00000074551 3 Not determined 2
LOC568327 KCNT2 ENSDARG00000075812 3 Not determined 2
mibp ITGB1BP3 ENSDARG00000094727 None Not determined 1
mibp2 ITGB1BP3 ENSDARG00000042931 None Not determined 1
NP_571768.1 ITGB1BP3 ENSDARG00000078945 None Not determined 1
pcf11 PCF11 ENSDARG00000044625 6 Not determined 2
plekha1 PLEKHA1 ENSDARG00000030064 1 Not determined 2
PLEKHA1 (2 of 2) PLEKHA1 ENSDARG00000094504 None Not determined 2
polr2b POLR2B ENSDARG00000012592 1 Not determined 2
postn POSTN ENSDARG00000061219 1 Not determined 1
pvrl2l PVRL2 ENSDARG00000063390 1 Not determined 9
pvrl4 PVRL2 ENSDARG00000094356 None Not determined 9
Q1RLV8_DANRE ZBTB41 ENSDARG00000054984 4 Not determined 1
Q5RI69_DANRE CFH ENSDARG00000094134 None Not determined 12
Q5RI69_DANRE CFHR3 ENSDARG00000094134 None Not determined 4
Q5RI69_DANRE CFHR4 ENSDARG00000094134 None Not determined 3
Q5RI69_DANRE CFHR2 ENSDARG00000094134 None Not determined 1
Q5RI69_DANRE CFHR5 ENSDARG00000094134 None Not determined 2
rab30 RAB30 ENSDARG00000037884 None Not determined 2
rest REST ENSDARG00000007222 1 Not determined 2
si:ch211-140f21.1 C3 ENSDARG00000001818 6 Not determined 6
si:ch211-141e20.2 PVRL2 ENSDARG00000093349 None Not determined 9
si:ch211-214p13.3 PVRL2 ENSDARG00000087403 1 Not determined 9
si:ch211-222f23.6 PVRL2 ENSDARG00000042880 1 Not determined 9
si:ch211-266d19.3 RREB1 ENSDARG00000063701 1 Not determined 6
si:ch211-279l9.6 RREB1 ENSDARG00000042652 5 Not determined 6
si:dkey-109i21.1 POSTN ENSDARG00000043806 4 Not determined 1
si:dkey-114d20.1 CFH ENSDARG00000092786 None Not determined 12
si:dkey-114d20.1 CFHR3 ENSDARG00000092786 None Not determined 4
si:dkey-114d20.1 CFHR4 ENSDARG00000092786 None Not determined 3
si:dkey-114d20.1 CFHR2 ENSDARG00000092786 None Not determined 1
si:dkey-114d20.1 CFHR5 ENSDARG00000092786 None Not determined 2
si:dkey-114d20.3 CFH ENSDARG00000091868 None Not determined 12
si:dkey-114d20.3 CFHR3 ENSDARG00000091868 None Not determined 4
si:dkey-114d20.3 CFHR4 ENSDARG00000091868 None Not determined 3
si:dkey-114d20.3 CFHR2 ENSDARG00000091868 None Not determined 1
si:dkey-114d20.3 CFHR5 ENSDARG00000091868 None Not determined 2
si:dkey-21e7.2 C3 ENSDARG00000093068 8 Not determined 6
si:dkey-240h12.4 DAPK3 ENSDARG00000034210 4 Not determined 1
si:dkey-281i8.1 PVRL2 ENSDARG00000069936 None Not determined 9
si:dkey-76b14.4 C3 ENSDARG00000012694 9 Normal 6
si:dkey-76b14.5 C3 ENSDARG00000053462 3 Not determined 6
si:dkey-78k11.2 CD46 ENSDARG00000095512 None Not determined 3
skiv2l SKIV2L ENSDARG00000062206 7 Not determined 1
tnfrsfa TNFRSF10A ENSDARG00000004451 2 Not determined 1
tnxb TNXB ENSDARG00000001760 5 Not determined 4
tomm40 TOMM40 ENSDARG00000092112 1 Not determined 23
tomm40l TOMM40 ENSDARG00000036721 None Not determined 23
trpc4 TRPC4 ENSDARG00000062183 4 Not determined 2
tyr TYR ENSDARG00000039077 None Not determined 9
vegfaa VEGFA ENSDARG00000045971 None Not determined 8
vegfab VEGFA ENSDARG00000034700 None Not determined 8
zgc:103710 C3 ENSDARG00000043719 2 Not determined 6
zgc:110064 APOE ENSDARG00000086370 1 Not determined 42
zgc:110182 FAM84B ENSDARG00000040280 None Not determined 2
zgc:110775 CD46 ENSDARG00000056075 1 Not determined 3
zgc:158446 CFB ENSDARG00000090730 4 Not determined 6
zgc:175125 C4orf14 ENSDARG00000073788 None Not determined 2

The following reported genes could not be linked automatically to a zebrafish gene:

  • ARMS2
  • ARMS2
  • ARMS2
  • ARMS2
  • ARMS2
  • ARMS2
  • ARMS2
  • BF
  • CD34
  • CD34
  • CFHR1P
  • LOC389641
  • NOTCH4
  • R102G
  • TIMP3
  • TIMP3
  • TIMP3
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