GWAS

(GWAS data used on the Zebrafish Mutation Project Web site comes from http://www.genome.gov/gwastudies/.)

Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.

The human homologues of the following genes have been identified in this study:

Gene name Reported Gene Ensembl ID Alleles found Associated phenotype Study Count
abcf2 ABCF2 ENSDARG00000038785 1 Not determined 2
ABCF2 (2 of 2) ABCF2 ENSDARG00000052331 None Not determined 2
ankrd55 ANKRD55 ENSDARG00000053869 5 Not determined 6
b4galt1 B4GALT1 ENSDARG00000002634 1 Not determined 2
bach2 BACH2 ENSDARG00000004074 2 Not determined 14
cacna1i CACNA1I ENSDARG00000070522 6 Not determined 2
derl3 DERL3 ENSDARG00000033871 1 Not determined 1
fut8 FUT8 ENSDARG00000015449 2 Not determined 5
ikzf1 IKZF1 ENSDARG00000013539 4 Not determined 10
il6st IL6ST ENSDARG00000030498 5 Normal 3
lamb1a LAMB1 ENSDARG00000026491 1 Not determined 4
lamb1a LAMB1 ENSDARG00000089288 1 Not determined 4
lamb1b LAMB1 ENSDARG00000045524 7 Normal 4
lamb2l LAMB1 ENSDARG00000033950 2 Not determined 4
LOC100331714 FUT8 ENSDARG00000088117 3 Not determined 5
LOC100334698 RECK ENSDARG00000090039 1 Not determined 1
LOC557210 BACH2 ENSDARG00000036569 4 Not determined 14
mgat3 MGAT3 ENSDARG00000038069 2 Not determined 1
MGAT3 (1 of 2) MGAT3 ENSDARG00000036619 2 Not determined 1
mhc2dab HLA-DQB2 ENSDARG00000079105 None Not determined 3
NP_001091732.1 HLA-DQB2 ENSDARG00000071168 1 Not determined 3
pex5 PEX5 ENSDARG00000070654 1 Not determined 1
prrt1 PRRT1 ENSDARG00000062208 None Not determined 2
si:busm1-104n07.3 HLA-DQB2 ENSDARG00000074510 1 Normal 3
si:busm1-160c18.1 HLA-DQA2 ENSDARG00000053739 2 Not determined 17
si:busm1-160c18.3 HLA-DQB2 ENSDARG00000053738 None Not determined 3
si:busm1-160c18.3 HLA-DQB2 ENSDARG00000093706 None Not determined 3
si:busm1-194e12.11 HLA-DQA2 ENSDARG00000055441 1 Not determined 17
si:busm1-194e12.12 HLA-DQB2 ENSDARG00000055447 None Not determined 3
si:busm1-228j01.3 HLA-DQA2 ENSDARG00000086294 2 Not determined 17
si:busm1-228j01.4 HLA-DQB2 ENSDARG00000088872 2 Not determined 3
si:busm1-228j01.5 HLA-DQA2 ENSDARG00000079593 3 Not determined 17
si:busm1-228j01.6 HLA-DQB2 ENSDARG00000041705 1 Not determined 3
si:ch1073-403i13.1 HLA-DQA2 ENSDARG00000001832 None Not determined 17
si:ch73-211l2.3 HLA-DQA2 ENSDARG00000075932 1 Not determined 17
si:dkeyp-2h4.2 HLA-DQA2 ENSDARG00000031745 None Not determined 17
si:zfos-2070c2.1 HLA-DQA2 ENSDARG00000070206 None Not determined 17
si:zfos-2070c2.3 HLA-DQB2 ENSDARG00000076307 None Not determined 3
si:zfos-367g9.1 HLA-DQA2 ENSDARG00000074816 1 Not determined 17
slc38a10 SLC38A10 ENSDARG00000077081 1 Not determined 2
smarcb1a SMARCB1 ENSDARG00000033647 None Not determined 1
smarcb1b SMARCB1 ENSDARG00000011594 None Not determined 1
smarcd3a SMARCD3 ENSDARG00000038786 1 Not determined 1
smarcd3b SMARCD3 ENSDARG00000019969 2 Not determined 1
st6gal1 ST6GAL1 ENSDARG00000044514 2 Not determined 4
suv420h1 SUV420H1 ENSDARG00000041081 4 Not determined 1
syngr1a SYNGR1 ENSDARG00000002564 None Not determined 1
syngr1b SYNGR1 ENSDARG00000023209 2 Not determined 1
tab1 TAB1 ENSDARG00000036613 None Not determined 2
wu:fd58b11 HLA-DQB2 ENSDARG00000054921 None Not determined 3
zgc:123107 HLA-DQA2 ENSDARG00000020286 None Not determined 17
zgc:153067 HLA-DQB2 ENSDARG00000056330 2 Not determined 3
zgc:154116 B4GALT1 ENSDARG00000052326 2 Not determined 2
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