GWAS

(GWAS data used on the Zebrafish Mutation Project Web site comes from http://www.genome.gov/gwastudies/.)

Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus.

The human homologues of the following genes have been identified in this study:

Gene name Reported Gene Ensembl ID Alleles found Associated phenotype Study Count
akap13 AKAP13 ENSDARG00000023868 None Not determined 2
AKAP13 (2 of 2) AKAP13 ENSDARG00000079358 1 Not determined 2
arhgap20 ARHGAP20 ENSDARG00000089326 3 Not determined 3
arhgap20b ARHGAP20 ENSDARG00000093708 None Not determined 3
ARID5B ARID5B ENSDARG00000037196 2 Not determined 7
B0S5R9_DANRE FGF9 ENSDARG00000087715 None Not determined 1
banp BANP ENSDARG00000017562 3 Not determined 2
chsy1 CHSY1 ENSDARG00000079027 2 Not determined 1
col4a3 COL4A3 ENSDARG00000003395 3 Not determined 2
fam46a FAM46A ENSDARG00000054641 None Not determined 3
fgf20a FGF9 ENSDARG00000007356 1 Not determined 1
fgf20b FGF9 ENSDARG00000086070 None Not determined 1
FNDC3B (2 of 3) FNDC3B ENSDARG00000088779 1 Not determined 1
fndc3ba FNDC3B ENSDARG00000078179 4 Not determined 1
fndc3bb FNDC3B ENSDARG00000062023 5 Not determined 1
foxo1a FOXO1 ENSDARG00000063540 1 Not determined 3
foxo1b FOXO1 ENSDARG00000061549 1 Not determined 3
hs3st3b1a HS3ST3B1 ENSDARG00000059594 1 Not determined 2
hs3st3b1b HS3ST3B1 ENSDARG00000086645 None Not determined 2
hs3st3l HS3ST3B1 ENSDARG00000059903 None Not determined 2
IBTK IBTK ENSDARG00000074424 3 Not determined 1
kcnmb2 KCNMB2 ENSDARG00000006568 None Not determined 3
LOC100329339 HS3ST3B1 ENSDARG00000060253 None Not determined 2
LOC100330676 FAM46A ENSDARG00000037183 1 Not determined 3
LOC100332050 LRRK1 ENSDARG00000007398 5 Not determined 1
LOC796753 KCNMB2 ENSDARG00000001712 3 Not determined 3
lpar1 LPAR1 ENSDARG00000044213 1 Not determined 2
LRRK1 (2 of 2) LRRK1 ENSDARG00000089483 1 Not determined 1
NP_001003748.1 SGCG ENSDARG00000090096 None Not determined 3
nr3c2 NR3C2 ENSDARG00000037025 1 Not determined 5
pmp22a PMP22 ENSDARG00000032724 None Not determined 1
pmp22b PMP22 ENSDARG00000060457 None Not determined 1
rxraa RXRA ENSDARG00000057737 None Not determined 4
rxrab RXRA ENSDARG00000035127 3 Not determined 4
sgcg SGCG ENSDARG00000038107 2 Not determined 3
si:ch211-197n10.4 COL8A2 ENSDARG00000060893 2 Not determined 1
si:dkey-22l11.1 GLT8D2 ENSDARG00000057942 None Not determined 2
si:dkey-281i8.3 FGF9 ENSDARG00000078625 None Not determined 1
si:dkey-33l14.1 TJP1 ENSDARG00000079374 3 Not determined 2
si:dkey-87m23.1 COL5A1 ENSDARG00000012593 7 Not determined 5
si:dkey-91i10.2 AKAP13 ENSDARG00000074034 1 Not determined 2
si:dkeyp-7g10.1 ADAMTS6 ENSDARG00000041982 2 Not determined 2
smad3a SMAD3 ENSDARG00000036096 2 Not determined 5
smad3b SMAD3 ENSDARG00000010207 2 Not determined 5
tbl1xr1 TBL1XR1 ENSDARG00000008966 4 Not determined 2
tjp1 TJP1 ENSDARG00000077506 5 Not determined 2
zgc:103561 C7orf42 ENSDARG00000018825 None Not determined 1
zgc:110312 TBL1XR1 ENSDARG00000058696 None Not determined 2
zgc:158398 C7orf42 ENSDARG00000074226 None Not determined 1
zgc:158706 ARID5B ENSDARG00000069988 None Not determined 7
zgc:77151 ARID5B ENSDARG00000054307 1 Not determined 7

The following reported genes could not be linked automatically to a zebrafish gene:

  • LCN12
  • MPDZ
  • NF1B
  • POU2AF1
  • PTGDS
  • VKORC1L1
  • ZNF469
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