GWAS

(GWAS data used on the Zebrafish Mutation Project Web site comes from http://www.genome.gov/gwastudies/.)

A genome-wide association study identifies 2 susceptibility Loci for Crohn's disease in a Japanese population.

The human homologues of the following genes have been identified in this study:

Gene name Reported Gene Ensembl ID Alleles found Associated phenotype Study Count
ATG16L2 ATG16L2 ENSDARG00000086191 None Not determined 1
FCHSD2 (6 of 6) FCHSD2 ENSDARG00000091428 1 Not determined 1
FCHSD2 (4 of 6) FCHSD2 ENSDARG00000091308 None Not determined 1
FCHSD2 (3 of 6) FCHSD2 ENSDARG00000091157 None Not determined 1
FCHSD2 (2 of 6) FCHSD2 ENSDARG00000089928 1 Not determined 1
FCHSD2 (1 of 6) FCHSD2 ENSDARG00000089638 None Not determined 1
jak2a JAK2 ENSDARG00000007915 2 Not determined 8
jak2b JAK2 ENSDARG00000018882 5 Not determined 8
mhc2dab HLA-DRB1 ENSDARG00000079105 None Not determined 35
mhc2dab HLA-DOB ENSDARG00000079105 None Not determined 2
mhc2dab HLA-DQB1 ENSDARG00000079105 None Not determined 24
NP_001091732.1 HLA-DRB1 ENSDARG00000071168 1 Not determined 35
NP_001091732.1 HLA-DOB ENSDARG00000071168 1 Not determined 2
NP_001091732.1 HLA-DQB1 ENSDARG00000071168 1 Not determined 24
pbx2 PBX2 ENSDARG00000019717 None Not determined 2
PBX2 (1 of 2) PBX2 ENSDARG00000092447 None Not determined 2
pbx3a PBX2 ENSDARG00000093513 None Not determined 2
psmb11 PSMB9 ENSDARG00000031885 None Not determined 3
psmb9a PSMB9 ENSDARG00000000656 None Not determined 3
Q7ZW49_DANRE PBX2 ENSDARG00000086991 1 Not determined 2
runx3 RUNX3 ENSDARG00000052826 None Not determined 3
si:busm1-104n07.3 HLA-DRB1 ENSDARG00000074510 1 Normal 35
si:busm1-104n07.3 HLA-DOB ENSDARG00000074510 1 Normal 2
si:busm1-104n07.3 HLA-DQB1 ENSDARG00000074510 1 Normal 24
si:busm1-160c18.1 HLA-DQA2 ENSDARG00000053739 2 Not determined 17
si:busm1-160c18.1 HLA-DQA1 ENSDARG00000053739 2 Not determined 27
si:busm1-160c18.3 HLA-DQB1 ENSDARG00000053738 None Not determined 24
si:busm1-160c18.3 HLA-DRB1 ENSDARG00000053738 None Not determined 35
si:busm1-160c18.3 HLA-DOB ENSDARG00000053738 None Not determined 2
si:busm1-160c18.3 HLA-DRB1 ENSDARG00000093706 None Not determined 35
si:busm1-160c18.3 HLA-DOB ENSDARG00000093706 None Not determined 2
si:busm1-160c18.3 HLA-DQB1 ENSDARG00000093706 None Not determined 24
si:busm1-194e12.11 HLA-DQA2 ENSDARG00000055441 1 Not determined 17
si:busm1-194e12.11 HLA-DQA1 ENSDARG00000055441 1 Not determined 27
si:busm1-194e12.12 HLA-DRB1 ENSDARG00000055447 None Not determined 35
si:busm1-194e12.12 HLA-DOB ENSDARG00000055447 None Not determined 2
si:busm1-194e12.12 HLA-DQB1 ENSDARG00000055447 None Not determined 24
si:busm1-228j01.3 HLA-DQA1 ENSDARG00000086294 2 Not determined 27
si:busm1-228j01.3 HLA-DQA2 ENSDARG00000086294 2 Not determined 17
si:busm1-228j01.4 HLA-DRB1 ENSDARG00000088872 2 Not determined 35
si:busm1-228j01.4 HLA-DOB ENSDARG00000088872 2 Not determined 2
si:busm1-228j01.4 HLA-DQB1 ENSDARG00000088872 2 Not determined 24
si:busm1-228j01.5 HLA-DQA2 ENSDARG00000079593 3 Not determined 17
si:busm1-228j01.5 HLA-DQA1 ENSDARG00000079593 3 Not determined 27
si:busm1-228j01.6 HLA-DRB1 ENSDARG00000041705 1 Not determined 35
si:busm1-228j01.6 HLA-DOB ENSDARG00000041705 1 Not determined 2
si:busm1-228j01.6 HLA-DQB1 ENSDARG00000041705 1 Not determined 24
si:ch1073-403i13.1 HLA-DQA2 ENSDARG00000001832 None Not determined 17
si:ch1073-403i13.1 HLA-DQA1 ENSDARG00000001832 None Not determined 27
si:ch211-176g13.8 FCHSD2 ENSDARG00000095379 1 Not determined 1
si:ch73-211l2.3 HLA-DQA2 ENSDARG00000075932 1 Not determined 17
si:ch73-211l2.3 HLA-DQA1 ENSDARG00000075932 1 Not determined 27
si:dkeyp-2h4.2 HLA-DQA2 ENSDARG00000031745 None Not determined 17
si:dkeyp-2h4.2 HLA-DQA1 ENSDARG00000031745 None Not determined 27
si:zfos-2070c2.1 HLA-DQA2 ENSDARG00000070206 None Not determined 17
si:zfos-2070c2.1 HLA-DQA1 ENSDARG00000070206 None Not determined 27
si:zfos-2070c2.3 HLA-DRB1 ENSDARG00000076307 None Not determined 35
si:zfos-2070c2.3 HLA-DOB ENSDARG00000076307 None Not determined 2
si:zfos-2070c2.3 HLA-DQB1 ENSDARG00000076307 None Not determined 24
si:zfos-367g9.1 HLA-DQA2 ENSDARG00000074816 1 Not determined 17
si:zfos-367g9.1 HLA-DQA1 ENSDARG00000074816 1 Not determined 27
slc25a15a SLC25A15 ENSDARG00000063539 4 Not determined 1
slc25a15b SLC25A15 ENSDARG00000062271 2 Not determined 1
sox11a SOX11 ENSDARG00000077811 None Not determined 3
sox11b SOX11 ENSDARG00000095743 1 Not determined 3
stat3 STAT3 ENSDARG00000022712 5 Not determined 7
tbc1d1 TBC1D1 ENSDARG00000062081 5 Not determined 2
wu:fd58b11 HLA-DRB1 ENSDARG00000054921 None Not determined 35
wu:fd58b11 HLA-DOB ENSDARG00000054921 None Not determined 2
wu:fd58b11 HLA-DQB1 ENSDARG00000054921 None Not determined 24
zgc:112384 WBP4 ENSDARG00000068082 None Not determined 1
zgc:123107 HLA-DQA2 ENSDARG00000020286 None Not determined 17
zgc:123107 HLA-DQA1 ENSDARG00000020286 None Not determined 27
zgc:153067 HLA-DRB1 ENSDARG00000056330 2 Not determined 35
zgc:153067 HLA-DOB ENSDARG00000056330 2 Not determined 2
zgc:153067 HLA-DQB1 ENSDARG00000056330 2 Not determined 24

The following reported genes could not be linked automatically to a zebrafish gene:

  • ELF1
  • LOC100129633
  • LOC645266
  • microRNA2276
  • NOTCH4
  • PSORS1C3
  • TNFSF15
  • TNFSF8
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