GWAS

(GWAS data used on the Zebrafish Mutation Project Web site comes from http://www.genome.gov/gwastudies/.)

A genome-wide association study provides evidence for association of chromosome 8p23 (MYP10) and 10q21.1 (MYP15) with high myopia in the French Population.

The human homologues of the following genes have been identified in this study:

Gene name Reported Gene Ensembl ID Alleles found Associated phenotype Study Count
abca1a ABCA1 ENSDARG00000074635 9 Not determined 13
aspa ASPA ENSDARG00000005154 None Not determined 1
bmp6 BMP6 ENSDARG00000015686 None Not determined 4
C7U131_DANRE PTPRD ENSDARG00000044635 3 Not determined 11
capn9 CAPN9 ENSDARG00000012341 2 Not determined 1
dhx15 DHX15 ENSDARG00000015392 3 1 phenotype 1
dnah9 DNAH9 ENSDARG00000011633 None Not determined 1
DNAH9 (1 of 2) DNAH9 ENSDARG00000087466 None Not determined 1
fhit FHIT ENSDARG00000068850 None Not determined 9
fhit FHIT ENSDARG00000078195 None Not determined 9
fli1a FLI1 ENSDARG00000054632 1 Not determined 3
fli1b FLI1 ENSDARG00000040080 1 Not determined 3
gata4 GATA4 ENSDARG00000035759 2 Not determined 2
im:7149628 MSRA ENSDARG00000055270 1 Not determined 6
LOC569664 CLSTN2 ENSDARG00000060638 4 Not determined 4
ppp1r3b PPP1R3B ENSDARG00000044691 None Not determined 9
PTPRD (2 of 2) PTPRD ENSDARG00000059452 6 Not determined 11
ptprdb PTPRD ENSDARG00000019945 12 Normal 11
ptprn2 PTPRN2 ENSDARG00000035970 7 Not determined 4
si:ch211-273a21.1 CNTN5 ENSDARG00000013647 3 2 normal 6
si:ch211-51m24.3 CHD4 ENSDARG00000063535 6 Not determined 1
si:dkey-221h15.1 MSRA ENSDARG00000029587 3 Not determined 6
si:dkey-242g16.2 PPP1R3B ENSDARG00000069377 None Not determined 9
si:dkey-261o10.2 DENND1A ENSDARG00000014592 3 Not determined 3
si:dkeyp-55c8.1 CLSTN2 ENSDARG00000060637 4 Not determined 4
TACC2 TACC2 ENSDARG00000062790 2 Not determined 2
wu:fd12d03 CHD4 ENSDARG00000025789 2 Not determined 1
zgc:171581 ABCA1 ENSDARG00000079009 7 Not determined 13
zgc:55318 CNTN5 ENSDARG00000021584 3 Not determined 6
zgc:77112 PPP1R3B ENSDARG00000015657 None Not determined 9
zgc:85932 CAPN9 ENSDARG00000055094 1 Not determined 1
znf536 ZNF536 ENSDARG00000022251 3 Not determined 3

The following reported genes could not be linked automatically to a zebrafish gene:

  • KIAA1303
  • LOC100129620
  • LOC646021
  • MIR124-1
  • MIR4660
  • MYP10
  • PML
  • SRPK2
  • ZNF285A
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