GWAS

(GWAS data used on the Zebrafish Mutation Project Web site comes from http://www.genome.gov/gwastudies/.)

A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.

The human homologues of the following genes have been identified in this study:

Gene name Reported Gene Ensembl ID Alleles found Associated phenotype Study Count
A5PLH8_DANRE AKAP6 ENSDARG00000077295 4 Not determined 3
A8WFV8_DANRE VPS13C ENSDARG00000074465 16 Not determined 3
adra2a ADRA2A ENSDARG00000040841 4 Not determined 3
ARAP1 (3 of 3) ARAP1 ENSDARG00000087470 None Not determined 3
ARAP1 (1 of 3) ARAP1 ENSDARG00000091634 None Not determined 3
cdkn2b CDKN2B ENSDARG00000037262 2 Not determined 30
CHL1 (1 of 2) CHL1 ENSDARG00000076233 6 Not determined 7
chl1a CHL1 ENSDARG00000077881 4 Not determined 7
COBLL1 (2 of 2) COBLL1 ENSDARG00000089858 1 Not determined 3
COBLL1 (1 of 2) COBLL1 ENSDARG00000088979 None Not determined 3
cry-dash CRY2 ENSDARG00000002396 2 Not determined 3
cry3 CRY2 ENSDARG00000079444 None Not determined 3
cry4 CRY2 ENSDARG00000011890 1 Not determined 3
cry5 CRY2 ENSDARG00000019498 1 Not determined 3
DGKB DGKB ENSDARG00000027724 1 Not determined 4
dpysl5a DPYSL5 ENSDARG00000011141 2 Not determined 2
dpysl5b DPYSL5 ENSDARG00000059311 2 Not determined 2
foxa FOXA2 ENSDARG00000036385 None Not determined 2
foxa2 FOXA2 ENSDARG00000003411 None Not determined 2
foxn3 FOXN3 ENSDARG00000012833 1 Not determined 1
gck GCK ENSDARG00000068006 1 Not determined 7
glis3 GLIS3 ENSDARG00000069726 5 Not determined 6
grb10a GRB10 ENSDARG00000002013 3 Normal 3
GRB14 GRB14 ENSDARG00000068280 1 Not determined 5
igf1 IGF1 ENSDARG00000094132 None Not determined 5
igf2bp2a IGF2BP2 ENSDARG00000003421 1 Not determined 12
igf2bp2b IGF2BP2 ENSDARG00000061661 2 Not determined 12
lmo1 LMO1 ENSDARG00000034504 None Not determined 3
LOC100002134 SLC30A8 ENSDARG00000054584 1 Not determined 16
LOC100329739 CRY2 ENSDARG00000088549 2 Not determined 3
LOC100332526 ARAP1 ENSDARG00000086356 1 Not determined 3
LOC100333044 GCKR ENSDARG00000086620 None Not determined 39
LOC100334818 SLC2A2 ENSDARG00000001937 1 Not determined 3
LOC559281 IRS1 ENSDARG00000054087 2 Not determined 7
LOC560564 PDGFC ENSDARG00000077588 1 Not determined 2
LOC560642 SLC30A8 ENSDARG00000057629 None Not determined 16
madd MADD ENSDARG00000003495 8 Not determined 4
MR1BB_DANRE MTNR1B ENSDARG00000086493 None Not determined 15
mtnr1ba MTNR1B ENSDARG00000053833 None Not determined 15
mtnr1bb MTNR1B ENSDARG00000086883 None Not determined 15
NP_001165056.1 ADCY5 ENSDARG00000091342 1 Not determined 7
NP_571357.1 FOXA2 ENSDARG00000087094 None Not determined 2
NP_571861.2 CRY2 ENSDARG00000024049 None Not determined 3
pcsk1 PCSK1 ENSDARG00000002600 2 Normal 3
pdx1 PDX1 ENSDARG00000002779 4 Normal 2
pepd PEPD ENSDARG00000018020 2 Not determined 3
pparg PPARG ENSDARG00000031848 5 2 normal 8
ppp1r3b PPP1R3B ENSDARG00000044691 None Not determined 9
prox1 PROX1 ENSDARG00000055158 2 Not determined 2
prox1b PROX1 ENSDARG00000088810 2 Not determined 2
PTCHD3 (1 of 2) PTCHD3 ENSDARG00000010075 1 Not determined 1
sfmbt2 SFMBT2 ENSDARG00000045519 1 Not determined 1
si:ch211-135f11.1 ARAP1 ENSDARG00000062221 None Not determined 3
si:ch211-145o7.3 FOXN3 ENSDARG00000061548 None Not determined 1
si:ch211-149m3.3 GRB10 ENSDARG00000035308 8 Not determined 3
si:ch211-250m6.7 PTCHD3 ENSDARG00000068874 3 Not determined 1
si:ch211-266d19.3 RREB1 ENSDARG00000063701 1 Not determined 6
si:ch211-279l9.6 RREB1 ENSDARG00000042652 5 Not determined 6
si:ch73-90n13.2 UHRF1BP1 ENSDARG00000077011 3 Not determined 2
si:dkey-221l4.7 GRHL3 ENSDARG00000078552 1 Not determined 1
si:dkey-242g16.2 PPP1R3B ENSDARG00000069377 None Not determined 9
slc2a2 SLC2A2 ENSDARG00000056196 None Not determined 3
spry2 SPRY2 ENSDARG00000078308 1 Not determined 5
sulf1 SULF1 ENSDARG00000038428 5 Not determined 3
tcf7l2 TCF7L2 ENSDARG00000004415 5 Not determined 23
tuba7l TUBA3C ENSDARG00000002480 None Not determined 1
zgc:103559 DPYSL5 ENSDARG00000038293 3 Not determined 2
zgc:110848 LYPLAL1 ENSDARG00000088764 None Not determined 6
zgc:56306 IRS1 ENSDARG00000037099 1 Not determined 7
zgc:77112 PPP1R3B ENSDARG00000015657 None Not determined 9

The following reported genes could not be linked automatically to a zebrafish gene:

  • FADS1
  • FBXL10
  • G6PC2
  • MRPL33
  • OR4S1
  • SYN2
Short-link