GWAS

(GWAS data used on the Zebrafish Mutation Project Web site comes from http://www.genome.gov/gwastudies/.)

Common variants at 9p21 and 8q22 are associated with increased susceptibility to optic nerve degeneration in glaucoma.

The human homologues of the following genes have been identified in this study:

Gene name Reported Gene Ensembl ID Alleles found Associated phenotype Study Count
si:ch211-204a13.4 LRP12 ENSDARG00000059674 3 Not determined 2
six1a SIX1 ENSDARG00000039304 1 Not determined 4
six1b SIX1 ENSDARG00000026473 1 Not determined 4
six6a SIX6 ENSDARG00000025187 3 Not determined 4
six6b SIX6 ENSDARG00000031316 None Not determined 4
six7 SIX6 ENSDARG00000070107 None Not determined 4
six9 SIX1 ENSDARG00000068407 1 Not determined 4
six9 SIX6 ENSDARG00000068407 1 Not determined 4
zfpm2a ZFPM2 ENSDARG00000040123 2 Not determined 5
zfpm2b ZFPM2 ENSDARG00000035997 2 Not determined 5

The following reported genes could not be linked automatically to a zebrafish gene:

  • CDKN2BAS
  • CDKN2BAS
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