GWAS

(GWAS data used on the Zebrafish Mutation Project Web site comes from http://www.genome.gov/gwastudies/.)

Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.

The human homologues of the following genes have been identified in this study:

Gene name Reported Gene Ensembl ID Alleles found Associated phenotype Study Count
bat2 BAT2 ENSDARG00000031494 8 Not determined 2
bat5l BAT5 ENSDARG00000078929 2 Not determined 1
cacnb2a CACNB2 ENSDARG00000079906 1 Not determined 8
cacnb2b CACNB2 ENSDARG00000055565 3 Not determined 8
cyp17a1 CYP17A1 ENSDARG00000033566 3 Not determined 7
cyp17a2 CYP17A1 ENSDARG00000053966 None Not determined 7
cyp1a CYP1A1 ENSDARG00000026039 1 Not determined 5
cyp1d1 CYP1A1 ENSDARG00000035569 None Not determined 5
EDN3 (1 of 2) EDN3 ENSDARG00000070925 None Not determined 3
fgf5 FGF5 ENSDARG00000035377 1 Not determined 4
furina FURIN ENSDARG00000062909 3 Not determined 1
furinb FURIN ENSDARG00000070971 2 Not determined 1
gnas GNAS ENSDARG00000043094 1 Not determined 3
gosr2 GOSR2 ENSDARG00000053070 1 Not determined 3
gucy1a3 GUCY1A3 ENSDARG00000013787 None Not determined 3
jag1a JAG1 ENSDARG00000030289 5 Normal 5
jag1b JAG1 ENSDARG00000013168 3 Not determined 5
LOC100002893 SLC39A8 ENSDARG00000087905 None Not determined 4
LOC100334017 FES ENSDARG00000011449 4 Not determined 2
LOC556502 ADM ENSDARG00000015263 1 Not determined 5
LOC570100 ADM ENSDARG00000069027 None Not determined 5
mecom MECOM ENSDARG00000060808 2 Not determined 7
mhc1uba HFE ENSDARG00000075963 None Not determined 20
mhc1ze HFE ENSDARG00000074765 None Not determined 20
mhc1zel HFE ENSDARG00000092162 1 Not determined 20
mov10a MOV10 ENSDARG00000015829 5 Not determined 2
mov10b.1 MOV10 ENSDARG00000061177 4 Not determined 2
mov10b.2 MOV10 ENSDARG00000056065 5 Normal 2
npr3 NPR3 ENSDARG00000035253 1 Not determined 7
NP_919406.1 HFE ENSDARG00000086877 1 Not determined 20
nt5c2a NT5C2 ENSDARG00000039399 3 Not determined 9
nt5c2b NT5C2 ENSDARG00000058231 2 Not determined 9
plce1 PLCE1 ENSDARG00000089601 5 Not determined 7
PLCE1 (1 of 2) PLCE1 ENSDARG00000087921 4 Not determined 7
Q8MHB3_DANRE HFE ENSDARG00000076734 None Not determined 20
Q8MHB6_DANRE HFE ENSDARG00000088022 1 Not determined 20
SH2B3 (1 of 2) SH2B3 ENSDARG00000069958 None Not determined 19
si:ch211-119c24.3 EBF1 ENSDARG00000069196 1 Not determined 3
si:ch211-287j19.6 HFE ENSDARG00000001470 2 Not determined 20
si:ch211-51e8.2 EBF1 ENSDARG00000092635 1 Not determined 3
si:ch211-69e5.1 JAG1 ENSDARG00000079519 4 Not determined 5
si:ch73-213j4.4 HFE ENSDARG00000092731 None Not determined 20
si:ch73-34b5.3 GUCY1B3 ENSDARG00000086790 1 Not determined 2
si:ch73-38f1.1 EBF1 ENSDARG00000016116 2 Not determined 3
si:dkey-211h10.1 EDN3 ENSDARG00000086669 1 Not determined 3
si:dkeyp-1e8.2 SH2B3 ENSDARG00000093095 None Not determined 19
SLC39A8 (1 of 2) SLC39A8 ENSDARG00000056757 1 Normal 4
SLC4A7 SLC4A7 ENSDARG00000073952 4 Not determined 4
ULK3 ULK3 ENSDARG00000075200 2 Not determined 4
zgc:136614 HFE ENSDARG00000069471 None Not determined 20
zgc:64115 HFE ENSDARG00000036588 4 Not determined 20

The following reported genes could not be linked automatically to a zebrafish gene:

  • C5orf23
  • C5orf23
  • C5orf23
  • FLJ32810
  • FLJ32810
  • FLJ32810
  • TMEM133
  • TMEM133
  • TMEM133
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