GWAS

(GWAS data used on the Zebrafish Mutation Project Web site comes from http://www.genome.gov/gwastudies/.)

Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels.

The human homologues of the following genes have been identified in this study:

Gene name Reported Gene Ensembl ID Alleles found Associated phenotype Study Count
ascl1a ASCL1 ENSDARG00000038386 None Not determined 1
bcl7ba BCL7B ENSDARG00000026709 None Not determined 3
bcl7bb BCL7B ENSDARG00000040396 None Not determined 3
gprc6a GPRC6A ENSDARG00000005371 2 Not determined 2
hnf1a HNF1A ENSDARG00000009470 None Not determined 21
hnf4a HNF4A ENSDARG00000021494 1 Not determined 8
il6r IL6R ENSDARG00000070398 2 Not determined 7
irf1 IRF1 ENSDARG00000043492 None Not determined 6
irf11 IRF1 ENSDARG00000032768 1 Not determined 6
lepr LEPR ENSDARG00000070961 5 Not determined 6
LOC100333044 GCKR ENSDARG00000086620 None Not determined 39
pabpc4 PABPC4 ENSDARG00000059259 None Not determined 2
ppp1r3b PPP1R3B ENSDARG00000044691 None Not determined 9
psmg1 PSMG1 ENSDARG00000040620 None Not determined 3
ptpn2a PTPN2 ENSDARG00000016481 4 Not determined 13
ptpn2b PTPN2 ENSDARG00000035986 2 Not determined 13
rgs6 RGS6 ENSDARG00000015627 5 Not determined 4
roraa RORA ENSDARG00000031768 2 Not determined 11
rorab RORA ENSDARG00000001910 2 Not determined 11
sall1a SALL1 ENSDARG00000074319 3 Not determined 3
sall1b SALL1 ENSDARG00000075891 3 Not determined 3
si:ch211-234p6.10 CRP ENSDARG00000056498 None Not determined 13
si:ch211-234p6.12 CRP ENSDARG00000042613 None Not determined 13
si:ch211-234p6.13 CRP ENSDARG00000056462 None Not determined 13
si:ch211-234p6.14 CRP ENSDARG00000071454 2 Not determined 13
si:ch211-234p6.7 CRP ENSDARG00000071456 None Not determined 13
si:ch211-234p6.8 CRP ENSDARG00000071457 None Not determined 13
si:ch211-234p6.9 CRP ENSDARG00000095730 None Not determined 13
si:ch211-270n8.1 CRP ENSDARG00000045089 None Not determined 13
si:dkey-242g16.2 PPP1R3B ENSDARG00000069377 None Not determined 9
zgc:101049 CRP ENSDARG00000071051 1 Not determined 13
zgc:77112 PPP1R3B ENSDARG00000015657 None Not determined 9

The following reported genes could not be linked automatically to a zebrafish gene:

  • APOC1
  • IL1F10
  • NLRP3
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