GWAS

(GWAS data used on the Zebrafish Mutation Project Web site comes from http://www.genome.gov/gwastudies/.)

Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.

The human homologues of the following genes have been identified in this study:

Gene name Reported Gene Ensembl ID Alleles found Associated phenotype Study Count
A5PLF6_DANRE ADAD1 ENSDARG00000089181 3 Not determined 3
apeh APEH ENSDARG00000008703 None Not determined 1
APEH (3 of 3) APEH ENSDARG00000087726 1 Not determined 1
APEH (2 of 3) APEH ENSDARG00000088860 1 Not determined 1
BSN (2 of 2) BSN ENSDARG00000079822 23 Not determined 4
BSN (1 of 2) BSN ENSDARG00000079161 11 Not determined 4
BTNL2 BTNL2 ENSDARG00000093039 1 Not determined 18
card9 CARD9 ENSDARG00000067672 1 Not determined 9
exoc3 EXOC3 ENSDARG00000014582 2 Not determined 1
gmppb GMPPB ENSDARG00000017658 None Not determined 1
gna12 GNA12 ENSDARG00000025826 None Not determined 7
hsp70l HSPA6 ENSDARG00000021924 None Not determined 2
hsp70l HSPA6 ENSDARG00000055723 None Not determined 2
il10 IL10 ENSDARG00000078147 4 Normal 11
il12ba IL12B ENSDARG00000033727 2 Not determined 14
IL17REL IL17REL ENSDARG00000089131 2 Not determined 2
il34 IL19 ENSDARG00000090344 None Not determined 4
il7r IL7R ENSDARG00000078970 None Not determined 7
irf5 IRF5 ENSDARG00000045681 None Not determined 14
jak2a JAK2 ENSDARG00000007915 2 Not determined 8
jak2b JAK2 ENSDARG00000018882 5 Not determined 8
LOC100001302 UBA7 ENSDARG00000061222 2 Not determined 1
LOC100001799 IL12B ENSDARG00000069504 1 Not determined 14
LOC100330293 GPR35 ENSDARG00000086776 3 Not determined 3
LOC100330352 TNFRSF9 ENSDARG00000087225 1 Not determined 3
LOC100334078 GPR35 ENSDARG00000075877 None Not determined 3
LOC560703 MMEL1 ENSDARG00000026398 3 Not determined 6
LOC566707 AMIGO3 ENSDARG00000079569 1 Not determined 1
LOC797518 GNA12 ENSDARG00000037619 None Not determined 7
LOC798970 STMN3 ENSDARG00000038465 1 Not determined 1
mhc2dab HLA-DRB5 ENSDARG00000079105 None Not determined 6
mhc2dab HLA-DRB1 ENSDARG00000079105 None Not determined 35
NP_001091732.1 HLA-DRB5 ENSDARG00000071168 1 Not determined 6
NP_001091732.1 HLA-DRB1 ENSDARG00000071168 1 Not determined 35
NP_694512.1 MST1 ENSDARG00000031855 2 Not determined 9
park7 PARK7 ENSDARG00000034826 None Not determined 2
ptger4a PTGER4 ENSDARG00000059236 2 Normal 12
ptger4b PTGER4 ENSDARG00000035415 1 Not determined 12
Q1RLV3_DANRE SEC16A ENSDARG00000063300 3 Not determined 1
SERINC3 SERINC3 ENSDARG00000086133 None Not determined 2
si:busm1-104n07.3 HLA-DRB5 ENSDARG00000074510 1 Normal 6
si:busm1-104n07.3 HLA-DRB1 ENSDARG00000074510 1 Normal 35
si:busm1-160c18.1 HLA-DQA1 ENSDARG00000053739 2 Not determined 27
si:busm1-160c18.1 HLA-DRA ENSDARG00000053739 2 Not determined 21
si:busm1-160c18.3 HLA-DRB5 ENSDARG00000053738 None Not determined 6
si:busm1-160c18.3 HLA-DRB1 ENSDARG00000053738 None Not determined 35
si:busm1-160c18.3 HLA-DRB5 ENSDARG00000093706 None Not determined 6
si:busm1-160c18.3 HLA-DRB1 ENSDARG00000093706 None Not determined 35
si:busm1-194e12.11 HLA-DQA1 ENSDARG00000055441 1 Not determined 27
si:busm1-194e12.11 HLA-DRA ENSDARG00000055441 1 Not determined 21
si:busm1-194e12.12 HLA-DRB5 ENSDARG00000055447 None Not determined 6
si:busm1-194e12.12 HLA-DRB1 ENSDARG00000055447 None Not determined 35
si:busm1-228j01.3 HLA-DQA1 ENSDARG00000086294 2 Not determined 27
si:busm1-228j01.3 HLA-DRA ENSDARG00000086294 2 Not determined 21
si:busm1-228j01.4 HLA-DRB1 ENSDARG00000088872 2 Not determined 35
si:busm1-228j01.4 HLA-DRB5 ENSDARG00000088872 2 Not determined 6
si:busm1-228j01.5 HLA-DRA ENSDARG00000079593 3 Not determined 21
si:busm1-228j01.5 HLA-DQA1 ENSDARG00000079593 3 Not determined 27
si:busm1-228j01.6 HLA-DRB5 ENSDARG00000041705 1 Not determined 6
si:busm1-228j01.6 HLA-DRB1 ENSDARG00000041705 1 Not determined 35
si:ch1073-210b3.1 TNFRSF6B ENSDARG00000034243 None Not determined 4
si:ch1073-210b3.1 RTEL1 ENSDARG00000034243 None Not determined 7
si:ch1073-403i13.1 HLA-DQA1 ENSDARG00000001832 None Not determined 27
si:ch1073-403i13.1 HLA-DRA ENSDARG00000001832 None Not determined 21
si:ch211-163l21.4 C1orf106 ENSDARG00000078155 1 Not determined 3
si:ch211-199o1.2 HSPA6 ENSDARG00000056210 1 Not determined 2
si:ch211-208m13.1 AMIGO3 ENSDARG00000074469 None Not determined 1
si:ch211-213n8.3 IL12B ENSDARG00000054542 1 Not determined 14
si:ch211-234e14.2 PTGER4 ENSDARG00000079907 None Not determined 12
si:ch211-251b21.2 PLCH2 ENSDARG00000059960 2 Not determined 2
si:ch73-211l2.3 HLA-DQA1 ENSDARG00000075932 1 Not determined 27
si:ch73-211l2.3 HLA-DRA ENSDARG00000075932 1 Not determined 21
si:dkey-108d22.4 BSN ENSDARG00000063299 14 Normal 4
si:dkey-18n12.2 CCNY ENSDARG00000063677 None Not determined 1
si:dkey-1o2.3 SDCCAG3 ENSDARG00000095515 None Not determined 2
si:dkey-266j7.1 BSN ENSDARG00000012482 16 Not determined 4
si:dkey-90a13.6 ZBTB46 ENSDARG00000078191 1 Not determined 3
si:dkeyp-2h4.2 HLA-DQA1 ENSDARG00000031745 None Not determined 27
si:dkeyp-2h4.2 HLA-DRA ENSDARG00000031745 None Not determined 21
si:zfos-2070c2.1 HLA-DQA1 ENSDARG00000070206 None Not determined 27
si:zfos-2070c2.1 HLA-DRA ENSDARG00000070206 None Not determined 21
si:zfos-2070c2.3 HLA-DRB5 ENSDARG00000076307 None Not determined 6
si:zfos-2070c2.3 HLA-DRB1 ENSDARG00000076307 None Not determined 35
si:zfos-367g9.1 HLA-DQA1 ENSDARG00000074816 1 Not determined 27
si:zfos-367g9.1 HLA-DRA ENSDARG00000074816 1 Not determined 21
slc11a2 SLC11A1 ENSDARG00000024295 None Not determined 2
slc2a4rg SLC2A4RG ENSDARG00000077762 5 Not determined 3
snapc4 SNAPC4 ENSDARG00000067673 1 Not determined 3
tnpo3 TNPO3 ENSDARG00000045680 4 Not determined 7
wu:fd58b11 HLA-DRB5 ENSDARG00000054921 None Not determined 6
wu:fd58b11 HLA-DRB1 ENSDARG00000054921 None Not determined 35
zgc:101654 ORMDL3 ENSDARG00000025555 1 Not determined 14
zgc:113028 PIM3 ENSDARG00000055129 2 Not determined 2
zgc:123107 HLA-DQA1 ENSDARG00000020286 None Not determined 27
zgc:123107 HLA-DRA ENSDARG00000020286 None Not determined 21
zgc:136971 APEH ENSDARG00000055970 3 Not determined 1
zgc:153067 HLA-DRB5 ENSDARG00000056330 2 Not determined 6
zgc:153067 HLA-DRB1 ENSDARG00000056330 2 Not determined 35
zgc:153953 C1orf106 ENSDARG00000070571 2 Not determined 3
zgc:165612 INPP5E ENSDARG00000078655 1 Not determined 2
zgc:171472 PUS10 ENSDARG00000079973 None Not determined 4
zgc:171586 GPR35 ENSDARG00000074633 None Not determined 3
zgc:174006 HSPA6 ENSDARG00000029688 1 Not determined 2
zgc:174006 HSPA6 ENSDARG00000092362 None Not determined 2
zgc:63663 HSPA6 ENSDARG00000012381 None Not determined 2
zgc:85644 C1orf93 ENSDARG00000029795 2 Not determined 1
zgc:85939 AAMP ENSDARG00000045019 1 Not determined 2
zgpat ZGPAT ENSDARG00000027403 1 Not determined 2
ZGPAT (2 of 2) ZGPAT ENSDARG00000088134 None Not determined 2

The following reported genes could not be linked automatically to a zebrafish gene:

  • ARPC
  • DAP
  • ERFFI1
  • FCGR2A
  • FCGR2B
  • GSDML
  • ICOSLG
  • IFNG
  • IKZF3
  • IKZF3
  • IL1R2
  • IL2
  • IL21
  • IL23R
  • IL26
  • IL8RA
  • IL8RB
  • LSP1
  • PDRM1
  • PNMT
  • TNFRSF14
  • TNFSF15
  • TNFSF8
  • UTS2
  • ZFP90
  • ZPBP2
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