GWAS

(GWAS data used on the Zebrafish Mutation Project Web site comes from http://www.genome.gov/gwastudies/.)

Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease.

The human homologues of the following genes have been identified in this study:

Gene name Reported Gene Ensembl ID Alleles found Associated phenotype Study Count
abca1a ABCA1 ENSDARG00000074635 9 Not determined 13
adcy8 ADCY8 ENSDARG00000031783 6 Not determined 1
B6E520_DANRE PLXNA1 ENSDARG00000077437 4 Not determined 1
birc2 BIRC3 ENSDARG00000044619 None Not determined 1
cdc42ep1 CDC42EP3 ENSDARG00000062390 None Not determined 2
cmas CMAS ENSDARG00000057334 None Not determined 1
CMAS (3 of 3) CMAS ENSDARG00000089903 None Not determined 1
CMAS (2 of 3) CMAS ENSDARG00000091267 None Not determined 1
dnah9l DNAH11 ENSDARG00000062630 14 Not determined 5
dok2 DOK2 ENSDARG00000075818 None Not determined 1
ednrb1 EDNRB ENSDARG00000089334 None Not determined 1
f13a1 F13A1 ENSDARG00000036893 1 Not determined 2
FARP1 (2 of 2) FARP1 ENSDARG00000063695 1 Not determined 5
frmd6 FRMD6 ENSDARG00000002332 2 Not determined 4
GRIN2B (2 of 2) GRIN2B ENSDARG00000079348 3 Not determined 6
grin2bb GRIN2B ENSDARG00000030376 4 Not determined 6
hmgb1 HMGB1 ENSDARG00000079772 None Not determined 1
KCNT2 (2 of 2) KCNT2 ENSDARG00000091352 None Not determined 2
LOC558353 F13A1 ENSDARG00000094832 None Not determined 2
LOC560410 ADCY8 ENSDARG00000043141 5 Not determined 1
LOC565691 KCNT2 ENSDARG00000074551 3 Not determined 2
LOC568327 KCNT2 ENSDARG00000075812 3 Not determined 2
LOC795761 PLXNA1 ENSDARG00000075483 None Not determined 1
me2 ME2 ENSDARG00000015453 None Not determined 1
me2 ME2 ENSDARG00000086153 None Not determined 1
mpp7 MPP7 ENSDARG00000008366 None Not determined 4
MPP7 (3 of 3) MPP7 ENSDARG00000025168 None Not determined 4
MPP7 (2 of 3) MPP7 ENSDARG00000041883 None Not determined 4
ncam1a NCAM1 ENSDARG00000056181 4 Not determined 2
ncam1b NCAM1 ENSDARG00000007220 3 Not determined 2
pak2a PAK2 ENSDARG00000068177 1 Not determined 1
pak2b PAK2 ENSDARG00000018476 None Not determined 1
pcsk5a PCSK5 ENSDARG00000067537 7 Normal 5
pcsk5b PCSK5 ENSDARG00000060518 None Not determined 5
pds5b PDS5B ENSDARG00000061312 2 Not determined 1
plxna1 PLXNA1 ENSDARG00000061275 2 Not determined 1
PLXNA1 (4 of 4) PLXNA1 ENSDARG00000078641 2 Not determined 1
pou4f1 POU4F1 ENSDARG00000005559 1 Not determined 1
roraa RORA ENSDARG00000031768 2 Not determined 11
rorab RORA ENSDARG00000001910 2 Not determined 11
si:busm1-189a20.4 ZNF292 ENSDARG00000043973 5 Not determined 1
si:ch211-235f1.1 FARP1 ENSDARG00000074381 4 Not determined 5
si:ch211-247h9.1 CNTN4 ENSDARG00000062880 2 Not determined 6
si:ch211-260g14.4 SELP ENSDARG00000042138 5 Not determined 4
si:ch211-260g14.8 SELP ENSDARG00000009123 4 Not determined 4
si:ch211-72k22.4 EDNRB ENSDARG00000053498 1 Not determined 1
si:dkey-206f10.1 ADCY8 ENSDARG00000032838 2 Not determined 1
si:dkey-233k19.3 DNAH11 ENSDARG00000094282 6 Not determined 5
si:dkey-6h5.1 DNAH11 ENSDARG00000077384 15 Not determined 5
slc44a5a SLC44A5 ENSDARG00000017398 1 Not determined 2
slc44a5b SLC44A5 ENSDARG00000057419 3 Not determined 2
STXBP6 (1 of 2) STXBP6 ENSDARG00000088862 1 Not determined 3
stxbp6l STXBP6 ENSDARG00000028354 None Not determined 3
TXNDC6 TXNDC6 ENSDARG00000076395 1 Not determined 1
zgc:152982 F13A1 ENSDARG00000045453 4 Not determined 2
zgc:153573 CNTN4 ENSDARG00000019405 None Not determined 6
zgc:154093 CDC42EP3 ENSDARG00000055897 None Not determined 2
zgc:158291 POU4F1 ENSDARG00000044375 None Not determined 1
zgc:158387 MGST3 ENSDARG00000033364 None Not determined 1
zgc:165618 HMGB1 ENSDARG00000030479 1 Not determined 1
zgc:171581 ABCA1 ENSDARG00000079009 7 Not determined 13
zgc:171671 ZNF292 ENSDARG00000016763 13 Not determined 1
zgc:56518 MGST3 ENSDARG00000024143 None Not determined 1
zgc:92806 CDC42EP3 ENSDARG00000052783 None Not determined 2

The following reported genes could not be linked automatically to a zebrafish gene:

  • ARPP-21
  • CUBN
  • LOC392298
  • NCR2
  • RLBP1L1
  • TUSC1
  • UTS2D
  • YAP1
  • ZPBP
Short-link