GWAS

(GWAS data used on the Zebrafish Mutation Project Web site comes from http://www.genome.gov/gwastudies/.)

Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis.

The human homologues of the following genes have been identified in this study:

Gene name Reported Gene Ensembl ID Alleles found Associated phenotype Study Count
il12rb2 IL12RB2 ENSDARG00000052157 None Not determined 7
IL12RB2 (1 of 2) IL12RB2 ENSDARG00000093809 None Not determined 7
il12rb2l IL12RB2 ENSDARG00000074850 2 Not determined 7
il23r IL12RB2 ENSDARG00000052158 3 Not determined 7
irf5 IRF5 ENSDARG00000045681 None Not determined 14
mhc2dab HLA-DQB1 ENSDARG00000079105 None Not determined 24
NP_001091732.1 HLA-DQB1 ENSDARG00000071168 1 Not determined 24
si:busm1-104n07.3 HLA-DQB1 ENSDARG00000074510 1 Normal 24
si:busm1-160c18.3 HLA-DQB1 ENSDARG00000053738 None Not determined 24
si:busm1-160c18.3 HLA-DQB1 ENSDARG00000093706 None Not determined 24
si:busm1-194e12.12 HLA-DQB1 ENSDARG00000055447 None Not determined 24
si:busm1-228j01.4 HLA-DQB1 ENSDARG00000088872 2 Not determined 24
si:busm1-228j01.6 HLA-DQB1 ENSDARG00000041705 1 Not determined 24
si:zfos-2070c2.3 HLA-DQB1 ENSDARG00000076307 None Not determined 24
tnpo3 TNPO3 ENSDARG00000045680 4 Not determined 7
wu:fd58b11 HLA-DQB1 ENSDARG00000054921 None Not determined 24
zgc:101654 ORMDL3 ENSDARG00000025555 1 Not determined 14
zgc:153067 HLA-DQB1 ENSDARG00000056330 2 Not determined 24

The following reported genes could not be linked automatically to a zebrafish gene:

  • GSDMB
  • IKZF3
  • IL12A
  • ZPBP2
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