GWAS

(GWAS data used on the Zebrafish Mutation Project Web site comes from http://www.genome.gov/gwastudies/.)

Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.

The human homologues of the following genes have been identified in this study:

Gene name Reported Gene Ensembl ID Alleles found Associated phenotype Study Count
bcl11a BCL11A ENSDARG00000061352 3 Normal 10
cdkal1 CDKAL1 ENSDARG00000022122 2 Not determined 23
cdkn2b CDKN2B ENSDARG00000037262 2 Not determined 30
cdkn2b CDKN2A ENSDARG00000037262 2 Not determined 25
dusp7 DUSP9 ENSDARG00000032738 None Not determined 2
fto FTO ENSDARG00000044216 3 Not determined 32
hmga2 HMGA2 ENSDARG00000069912 None Not determined 18
hnf1a HNF1A ENSDARG00000009470 None Not determined 21
hnf1ba HNF1B ENSDARG00000006615 1 Not determined 8
hnf1bb HNF1B ENSDARG00000022295 None Not determined 8
ide IDE ENSDARG00000075570 4 Not determined 2
igf2bp2a IGF2BP2 ENSDARG00000003421 1 Not determined 12
igf2bp2b IGF2BP2 ENSDARG00000061661 2 Not determined 12
im:7150991 WFS1 ENSDARG00000074617 5 Not determined 2
jazf1a JAZF1 ENSDARG00000036243 1 Not determined 8
jazf1b JAZF1 ENSDARG00000056793 None Not determined 8
kcnq1 KCNQ1 ENSDARG00000059798 4 Not determined 15
KCNQ1 KCNQ1 ENSDARG00000091599 None Not determined 15
LOC100002134 SLC30A8 ENSDARG00000054584 1 Not determined 16
LOC100334833 HMGA2 ENSDARG00000091038 None Not determined 18
LOC559281 IRS1 ENSDARG00000054087 2 Not determined 7
LOC560642 SLC30A8 ENSDARG00000057629 None Not determined 16
MR1BB_DANRE MTNR1B ENSDARG00000086493 None Not determined 15
mtnr1ba MTNR1B ENSDARG00000053833 None Not determined 15
mtnr1bb MTNR1B ENSDARG00000086883 None Not determined 15
pparg PPARG ENSDARG00000031848 5 2 normal 8
prc1a PRC1 ENSDARG00000010511 None Not determined 1
prc1b PRC1 ENSDARG00000005993 2 Not determined 1
si:ch211-127m10.2 BCL11A ENSDARG00000063153 3 Not determined 10
tcf7l2 TCF7L2 ENSDARG00000004415 5 Not determined 23
tp53inp1 TP53INP1 ENSDARG00000028017 2 Not determined 1
WFS1 (1 of 2) WFS1 ENSDARG00000062341 3 Not determined 2
zgc:101121 ZFAND6 ENSDARG00000033811 2 Not determined 1
zgc:56306 IRS1 ENSDARG00000037099 1 Not determined 7
zgc:86764 PRC1 ENSDARG00000005098 None Not determined 1

The following reported genes could not be linked automatically to a zebrafish gene:

  • CENTD2
  • CHCHD9
  • HHEX
  • KLF14
  • LGR5
  • TCF2
  • TSPAN8
  • ZBED3
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