GWAS

(GWAS data used on the Zebrafish Mutation Project Web site comes from http://www.genome.gov/gwastudies/.)

New loci associated with kidney function and chronic kidney disease.

The human homologues of the following genes have been identified in this study:

Gene name Reported Gene Ensembl ID Alleles found Associated phenotype Study Count
amigo1 AMIGO1 ENSDARG00000079620 None Not determined 1
atxn7l2a ATXN7L2 ENSDARG00000055300 2 Not determined 2
atxn7l2b ATXN7L2 ENSDARG00000056268 1 Not determined 2
bcas3 BCAS3 ENSDARG00000054893 2 Normal 8
bcas3 BCAS3 ENSDARG00000090764 None Not determined 8
bnipl BNIPL ENSDARG00000060435 1 Not determined 1
c9 C9 ENSDARG00000016319 4 Not determined 1
ccdc123 CCDC123 ENSDARG00000005092 1 Not determined 1
cst3 CST3 ENSDARG00000007795 1 Not determined 2
cst3 CST4 ENSDARG00000007795 1 Not determined 1
cyb561d1 CYB561D1 ENSDARG00000055295 1 Not determined 3
dab2 DAB2 ENSDARG00000031761 1 Not determined 3
dachc DACH1 ENSDARG00000003142 1 Not determined 5
fam122b FAM122A ENSDARG00000036500 2 Not determined 1
fam63a FAM63A ENSDARG00000004866 1 Not determined 1
gatm GATM ENSDARG00000036239 2 Not determined 2
grk5 GRK6 ENSDARG00000032801 None Not determined 3
htatip KAT5 ENSDARG00000045951 1 Not determined 1
ift172 IFT172 ENSDARG00000041870 1 Not determined 2
lass2 LASS2 ENSDARG00000013704 None Not determined 2
lman2 LMAN2 ENSDARG00000061854 1 Not determined 2
LOC100002956 NAT8 ENSDARG00000078991 None Not determined 5
LOC100004652 NAT8 ENSDARG00000077028 None Not determined 5
LOC100329340 SLC34A1 ENSDARG00000028824 None Not determined 3
LOC100332162 FNDC4 ENSDARG00000009949 None Not determined 4
LOC100332592 SLC6A13 ENSDARG00000067567 1 Not determined 2
LOC100332592 SLC6A12 ENSDARG00000067567 1 Not determined 2
LOC100333044 GCKR ENSDARG00000086620 None Not determined 39
LOC558290 SYPL2 ENSDARG00000037587 1 Not determined 2
LOC561288 GRK6 ENSDARG00000032157 2 Not determined 3
LOC565295 LASS2 ENSDARG00000058992 1 Not determined 2
LOC565599 SLC34A1 ENSDARG00000054658 None Not determined 3
ovol1 OVOL1 ENSDARG00000076472 None Not determined 4
pfn1 PFN3 ENSDARG00000088091 None Not determined 3
pip5k1b PIP5K1B ENSDARG00000044295 3 Not determined 2
prkag2 PRKAG2 ENSDARG00000001933 1 Not determined 5
PRR7 PRR7 ENSDARG00000089800 None Not determined 2
prune PRUNE ENSDARG00000076246 None Not determined 1
psma5 PSMA5 ENSDARG00000003526 4 Not determined 1
RGS14 (1 of 2) RGS14 ENSDARG00000060200 1 Not determined 5
rgs14a RGS14 ENSDARG00000021521 None Not determined 5
RNASEH2C (2 of 2) RNASEH2C ENSDARG00000091285 None Not determined 1
setdb1a SETDB1 ENSDARG00000041243 1 Not determined 2
setdb1b SETDB1 ENSDARG00000061724 8 Not determined 2
SHROOM3 (2 of 2) SHROOM3 ENSDARG00000078705 2 Not determined 6
SHROOM3 (1 of 2) SHROOM3 ENSDARG00000090422 None Not determined 6
si:ch211-132b12.1 SLC6A12 ENSDARG00000061480 6 Not determined 2
si:ch211-132b12.1 SLC6A13 ENSDARG00000061480 6 Not determined 2
si:ch211-132b12.2 SLC6A12 ENSDARG00000094946 1 Not determined 2
si:ch211-132b12.2 SLC6A13 ENSDARG00000094946 1 Not determined 2
si:ch211-132b12.3 SLC6A12 ENSDARG00000068363 None Not determined 2
si:ch211-132b12.3 SLC6A13 ENSDARG00000068363 None Not determined 2
si:ch211-132b12.5 SLC6A13 ENSDARG00000068372 3 Not determined 2
si:ch211-132b12.5 SLC6A12 ENSDARG00000068372 3 Not determined 2
si:ch211-132b12.6 SLC6A12 ENSDARG00000094546 1 Not determined 2
si:ch211-132b12.6 SLC6A13 ENSDARG00000094546 1 Not determined 2
si:dkey-147f20.5 RNASEH2C ENSDARG00000089637 None Not determined 1
si:dkey-159a18.1 SORT1 ENSDARG00000056145 1 Not determined 13
si:dkey-165i4.1 ATXN2 ENSDARG00000052897 5 Normal 10
si:dkey-17e16.13 OVOL1 ENSDARG00000078256 1 Not determined 4
si:dkey-220o5.1 GRK6 ENSDARG00000078815 4 Not determined 3
si:dkey-225d17.3 CPS1 ENSDARG00000020028 6 Not determined 6
si:dkey-265c15.2 ALMS1 ENSDARG00000074779 5 Not determined 3
si:dkey-71h2.1 FNDC4 ENSDARG00000043396 None Not determined 4
slc6a11 SLC6A12 ENSDARG00000074002 3 Not determined 2
slc6a11 SLC6A13 ENSDARG00000074002 3 Not determined 2
slc6a13 SLC6A13 ENSDARG00000000730 1 Not determined 2
slc6a13 SLC6A12 ENSDARG00000000730 1 Not determined 2
slc6a13l SLC6A13 ENSDARG00000001354 5 Not determined 2
slc6a13l SLC6A12 ENSDARG00000001354 5 Not determined 2
slc7a9 SLC7A9 ENSDARG00000005894 None Not determined 3
sort1a SORT1 ENSDARG00000029402 1 Not determined 13
sort1b SORT1 ENSDARG00000056252 10 Not determined 13
sox11a SOX11 ENSDARG00000077811 None Not determined 3
sox11b SOX11 ENSDARG00000095743 1 Not determined 3
stc1 STC1 ENSDARG00000003303 1 Not determined 3
stc1l STC1 ENSDARG00000058476 None Not determined 3
synpr SYPL2 ENSDARG00000044278 None Not determined 2
sypl2a SYPL2 ENSDARG00000055307 2 Not determined 2
sypl2b SYPL2 ENSDARG00000000690 3 Not determined 2
tbx16 TBX2 ENSDARG00000007329 None Not determined 5
tbx2a TBX2 ENSDARG00000018025 1 Not determined 5
tbx2b TBX2 ENSDARG00000006120 None Not determined 5
tbx6 TBX2 ENSDARG00000006939 1 Not determined 5
tfdp2 TFDP2 ENSDARG00000042835 2 Not determined 1
ube2q1 UBE2Q2 ENSDARG00000007714 2 Not determined 2
ube2q2 UBE2Q2 ENSDARG00000013990 2 Not determined 2
vegfaa VEGFA ENSDARG00000045971 None Not determined 8
vegfab VEGFA ENSDARG00000034700 None Not determined 8
wdr37 WDR37 ENSDARG00000074611 1 Not determined 2
zgc:101785 ANXA9 ENSDARG00000053593 2 Not determined 3
zgc:136472 PDILT ENSDARG00000058445 2 Not determined 1
zgc:153294 SPATA5L1 ENSDARG00000061763 1 Not determined 3
zgc:153329 PRKAG2 ENSDARG00000012625 None Not determined 5
zgc:158869 DACH1 ENSDARG00000069440 4 Not determined 5
zgc:163030 CST3 ENSDARG00000069192 1 Not determined 2
zgc:163030 CST4 ENSDARG00000069192 1 Not determined 1
zgc:64076 SLC22A2 ENSDARG00000030530 2 Not determined 2
zgc:92022 PHTF2 ENSDARG00000077204 None Not determined 3
zgc:92316 PIP5K1B ENSDARG00000006508 5 Not determined 2
zgc:92510 KAT5 ENSDARG00000004587 None Not determined 1

The following reported genes could not be linked automatically to a zebrafish gene:

  • ACSM5
  • C17orf82
  • CCDC158
  • CST9
  • ECAT8
  • F12
  • FBX022
  • GP2
  • JARID1A
  • NAT8B
  • RSBN1L
  • TMEM60
  • UMOD
  • WDR72
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