GWAS

(GWAS data used on the Zebrafish Mutation Project Web site comes from http://www.genome.gov/gwastudies/.)

Multiple common variants for celiac disease influencing immune gene expression.

The human homologues of the following genes have been identified in this study:

Gene name Reported Gene Ensembl ID Alleles found Associated phenotype Study Count
A8WGB2_DANRE CCR9 ENSDARG00000053943 None Not determined 1
bach2 BACH2 ENSDARG00000004074 2 Not determined 14
ccr9a CCR9 ENSDARG00000055186 1 Not determined 1
ccr9b CCR9 ENSDARG00000068310 None Not determined 1
cd247l CD247 ENSDARG00000077240 1 Not determined 6
ciita CIITA ENSDARG00000090851 1 Not determined 2
faslg FASLG ENSDARG00000011520 None Not determined 3
irf4a IRF4 ENSDARG00000006560 1 Not determined 7
irf4b IRF4 ENSDARG00000055374 None Not determined 7
LOC100005846 ELMO1 ENSDARG00000055400 None Not determined 8
LOC100330352 TNFRSF9 ENSDARG00000087225 1 Not determined 3
LOC100331333 ITGA4 ENSDARG00000061186 3 Not determined 3
LOC100332583 TLR8 ENSDARG00000090119 None Not determined 1
LOC100332780 ZMIZ1 ENSDARG00000076477 3 Not determined 10
LOC557210 BACH2 ENSDARG00000036569 4 Not determined 14
LOC560703 MMEL1 ENSDARG00000026398 3 Not determined 6
LOC799279 IL1RL2 ENSDARG00000090844 None Not determined 2
LOC799279 IL1RL1 ENSDARG00000090844 None Not determined 8
lpp LPP ENSDARG00000023578 1 Not determined 10
map3k7 MAP3K7 ENSDARG00000020469 2 Not determined 2
mhc2dab HLA-DQB1 ENSDARG00000079105 None Not determined 24
nfia NFIA ENSDARG00000062420 2 Not determined 6
NP_001091732.1 HLA-DQB1 ENSDARG00000071168 1 Not determined 24
NP_998256.1 ELMO1 ENSDARG00000019258 2 Not determined 8
park7 PARK7 ENSDARG00000034826 None Not determined 2
plek PLEK ENSDARG00000017298 1 Not determined 4
ptpn2a PTPN2 ENSDARG00000016481 4 Not determined 13
ptpn2b PTPN2 ENSDARG00000035986 2 Not determined 13
ptprk PTPRK ENSDARG00000063416 1 Not determined 2
rel REL ENSDARG00000055276 4 Not determined 10
runx3 RUNX3 ENSDARG00000052826 None Not determined 3
SH2B3 (1 of 2) SH2B3 ENSDARG00000069958 None Not determined 19
si:busm1-104n07.3 HLA-DQB1 ENSDARG00000074510 1 Normal 24
si:busm1-160c18.1 HLA-DQA1 ENSDARG00000053739 2 Not determined 27
si:busm1-160c18.3 HLA-DQB1 ENSDARG00000053738 None Not determined 24
si:busm1-160c18.3 HLA-DQB1 ENSDARG00000093706 None Not determined 24
si:busm1-194e12.11 HLA-DQA1 ENSDARG00000055441 1 Not determined 27
si:busm1-194e12.12 HLA-DQB1 ENSDARG00000055447 None Not determined 24
si:busm1-228j01.3 HLA-DQA1 ENSDARG00000086294 2 Not determined 27
si:busm1-228j01.4 HLA-DQB1 ENSDARG00000088872 2 Not determined 24
si:busm1-228j01.5 HLA-DQA1 ENSDARG00000079593 3 Not determined 27
si:busm1-228j01.6 HLA-DQB1 ENSDARG00000041705 1 Not determined 24
si:ch1073-403i13.1 HLA-DQA1 ENSDARG00000001832 None Not determined 27
si:ch211-152p11.4 RGS1 ENSDARG00000079705 3 Not determined 3
si:ch211-160b7.1 CD28 ENSDARG00000095070 None Not determined 2
si:ch211-160b7.1 CTLA4 ENSDARG00000095070 None Not determined 9
si:ch211-251n20.3 RGS1 ENSDARG00000089077 None Not determined 3
si:ch211-274c22.6 TNFAIP3 ENSDARG00000027777 5 Not determined 11
si:ch73-191k20.2 SOCS1 ENSDARG00000089873 None Not determined 3
si:ch73-205c16.1 FRMD4B ENSDARG00000076496 None Not determined 1
si:ch73-211l2.3 HLA-DQA1 ENSDARG00000075932 1 Not determined 27
si:ch73-233m11.2 CIITA ENSDARG00000091859 None Not determined 2
si:dkeyp-1e8.2 SH2B3 ENSDARG00000093095 None Not determined 19
si:dkeyp-2h4.2 HLA-DQA1 ENSDARG00000031745 None Not determined 27
si:zfos-2070c2.1 HLA-DQA1 ENSDARG00000070206 None Not determined 27
si:zfos-2070c2.3 HLA-DQB1 ENSDARG00000076307 None Not determined 24
si:zfos-367g9.1 HLA-DQA1 ENSDARG00000074816 1 Not determined 27
socs1 SOCS1 ENSDARG00000038095 1 Not determined 3
tagap TAGAP ENSDARG00000043475 4 Not determined 7
themis THEMIS ENSDARG00000010619 4 Not determined 2
tlr7 TLR7 ENSDARG00000068812 4 Not determined 1
tlr8a TLR8 ENSDARG00000089151 3 Not determined 1
tlr8b TLR8 ENSDARG00000073675 1 Not determined 1
ube2e3 UBE2E3 ENSDARG00000012244 1 Not determined 2
ube2l3a UBE2L3 ENSDARG00000019188 None Not determined 8
ube2l3b UBE2L3 ENSDARG00000027141 1 Not determined 8
wu:fb59f02 FRMD4B ENSDARG00000074599 2 Not determined 1
wu:fd58b11 HLA-DQB1 ENSDARG00000054921 None Not determined 24
ydjc YDJC ENSDARG00000062655 None Not determined 4
zfp36l1a ZFP36L1 ENSDARG00000016154 None Not determined 4
zfp36l1b ZFP36L1 ENSDARG00000021443 None Not determined 4
zgc:123107 HLA-DQA1 ENSDARG00000020286 None Not determined 27
zgc:153067 HLA-DQB1 ENSDARG00000056330 2 Not determined 24
zgc:56230 CLEC16A ENSDARG00000038094 3 Not determined 13
zgc:77799 TAGAP ENSDARG00000002353 None Not determined 7
zmiz1 ZMIZ1 ENSDARG00000074502 10 Not determined 10

The following reported genes could not be linked automatically to a zebrafish gene:

  • AHSA2
  • CCR1
  • CCR2
  • CCR3
  • CCR4
  • CCR5
  • CCRL2
  • CD80
  • ETS1
  • ICOS
  • ICOSLG
  • IL12A
  • IL18R1
  • IL18RAP
  • IL2
  • IL21
  • KTELC1
  • TNFRSF14
  • TNFSF18
  • TNFSF4
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